{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:29:06Z","timestamp":1771680546013,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Funds (ERDF)","award":["UIDB\/00102\/2020"],"award-info":[{"award-number":["UIDB\/00102\/2020"]}]},{"name":"European Regional Development Funds (ERDF)","award":["2022.02495.PTDC"],"award-info":[{"award-number":["2022.02495.PTDC"]}]},{"name":"Operational Programme for Competitiveness and Internationalisation\u2014COMPETE2020","award":["UIDB\/00102\/2020"],"award-info":[{"award-number":["UIDB\/00102\/2020"]}]},{"name":"Operational Programme for Competitiveness and Internationalisation\u2014COMPETE2020","award":["2022.02495.PTDC"],"award-info":[{"award-number":["2022.02495.PTDC"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["UIDB\/00102\/2020"],"award-info":[{"award-number":["UIDB\/00102\/2020"]}]},{"name":"FCT\u2014Foundation for Science and Technology","award":["2022.02495.PTDC"],"award-info":[{"award-number":["2022.02495.PTDC"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","doi-asserted-by":"publisher","award":["UIDB\/00102\/2020"],"award-info":[{"award-number":["UIDB\/00102\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","doi-asserted-by":"publisher","award":["2022.02495.PTDC"],"award-info":[{"award-number":["2022.02495.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Call for R&amp;D Projects in All Scientific Domains\u20132022","award":["UIDB\/00102\/2020"],"award-info":[{"award-number":["UIDB\/00102\/2020"]}]},{"name":"Call for R&amp;D Projects in All Scientific Domains\u20132022","award":["2022.02495.PTDC"],"award-info":[{"award-number":["2022.02495.PTDC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Silica aerogel is a material composed of SiO2 that has exceptional physical properties when utilized for tissue engineering applications. Poly-\u03b5-caprolactone (PCL) is a biodegradable polyester that has been widely used for biomedical applications, namely as sutures, drug carriers, and implantable scaffolds. Herein, a hybrid composite of silica aerogel, prepared with two different silica precursors, tetraethoxysilane (TEOS) or methyltrimethoxysilane (MTMS), and PCL was synthesized to fulfil bone regeneration requirements. The developed porous hybrid biocomposite scaffolds were extensively characterized, regarding their physical, morphological, and mechanical features. The results showed that their properties were relevant, leading to composites with different properties. The water absorption capacity and mass loss were evaluated as well as the influence of the different hybrid scaffolds on osteoblasts\u2019 viability and morphology. Both hybrid scaffolds showed a hydrophobic character (with water contact angles higher than 90\u00b0), low swelling (maximum of 14%), and low mass loss (1\u20137%). hOB cells exposed to the different silica aerogel-PCL scaffolds remained highly viable, even for long periods of incubation (7 days). Considering the obtained results, the produced hybrid scaffolds may be good candidates for future application in bone tissue engineering.<\/jats:p>","DOI":"10.3390\/ijms241210128","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:32:57Z","timestamp":1686792777000},"page":"10128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Silica Aerogel-Polycaprolactone Scaffolds for Bone Tissue Engineering"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-4645","authenticated-orcid":false,"given":"Ana Dora Rodrigues","family":"Pontinha","sequence":"first","affiliation":[{"name":"University of Coimbra, CIEPQPF, Department of Chemical Engineering, Faculty of Sciences and Technology, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"},{"name":"University of Coimbra, ISISE, Department of Civil Engineering, Rua Lu\u00eds Reis Santos, 3030-788 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-9411","authenticated-orcid":false,"given":"Beatriz Barbosa","family":"Moreira","sequence":"additional","affiliation":[{"name":"University of Coimbra, CIEPQPF, Department of Chemical Engineering, Faculty of Sciences and Technology, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"}]},{"given":"Bruna Lopes","family":"Melo","sequence":"additional","affiliation":[{"name":"CICS-UBI, Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"Duarte de","family":"Melo-Diogo","sequence":"additional","affiliation":[{"name":"CICS-UBI, Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-9675","authenticated-orcid":false,"given":"Il\u00eddio Joaquim","family":"Correia","sequence":"additional","affiliation":[{"name":"CICS-UBI, Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-8329","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Alves","sequence":"additional","affiliation":[{"name":"University of Coimbra, CIEPQPF, Department of Chemical Engineering, Faculty of Sciences and Technology, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/127741a0","article-title":"Coherent Expanded Aerogels","volume":"127","author":"Kistler","year":"1931","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.micromeso.2017.09.016","article-title":"A reconsideration on the definition of the term aerogel based on current drying trends","volume":"258","author":"Vareda","year":"2018","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1039\/C7TA08959G","article-title":"Advances in carbon nanostructure-silica aerogel composites: A review","volume":"6","author":"Silva","year":"2018","journal-title":"J. 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