{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:32:10Z","timestamp":1769632330346,"version":"3.49.0"},"reference-count":21,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}]},{"name":"FCT","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]},{"name":"i4HB","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}]},{"name":"i4HB","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic kidney disease (CKD) is an epidemic health issue that requires global attention [...]<\/jats:p>","DOI":"10.3390\/ijms241512363","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T11:04:38Z","timestamp":1690974278000},"page":"12363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic Kidney Disease: Underlying Molecular Mechanisms\u2014A Special Issue Overview"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-6850","authenticated-orcid":false,"given":"Lu\u00eds","family":"Belo","sequence":"first","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\/REQUIMTE, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-4751","authenticated-orcid":false,"given":"M\u00e1rcia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\/REQUIMTE, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"FP-I3ID, FP-BHS, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.kint.2021.06.028","article-title":"Harmonizing acute and chronic kidney disease definition and classification: Report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference","volume":"100","author":"Lameire","year":"2021","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mishra, M., Nichols, L., Dave, A.A., Pittman, E.H., Cheek, J.P., Caroland, A.J.V., Lotwala, P., Drummond, J., and Bridges, C.C. (2022). Molecular Mechanisms of Cellular Injury and Role of Toxic Heavy Metals in Chronic Kidney Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911105"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Yamaguchi, J., Tanaka, T., and Nangaku, M. (2015). Recent advances in understanding of chronic kidney disease. F1000Research, 4.","DOI":"10.12688\/f1000research.6970.1"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lousa, I., Reis, F., Santos-Silva, A., and Belo, L. (2022). The Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063284"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1681\/ASN.2020040487","article-title":"Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"32","author":"Schrauben","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00011-022-01574-2","article-title":"Inflammatory biomarkers in staging of chronic kidney disease: Elevated TNFR2 levels accompanies renal function decline","volume":"71","author":"Lousa","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lousa, I., Reis, F., Beir\u00e3o, I., Alves, R., Belo, L., and Santos-Silva, A. (2020). New Potential Biomarkers for Chronic Kidney Disease Management-A Review of the Literature. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010043"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chebotareva, N.V., Vinogradov, A., Brzhozovskiy, A.G., Kashirina, D.N., Indeykina, M.I., Bugrova, A.E., Lebedeva, M., Moiseev, S., Nikolaev, E.N., and Kononikhin, A.S. (2022). Potential Urine Proteomic Biomarkers for Focal Segmental Glomerulosclerosis and Minimal Change Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012607"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1681\/ASN.2016111215","article-title":"MicroRNA-92a Mediates Endothelial Dysfunction in CKD","volume":"28","author":"Shang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.2147\/DDDT.S150825","article-title":"Gut microbiota-derived short-chain fatty acids and kidney diseases","volume":"11","author":"Li","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Magliocca, G., Mone, P., Di Iorio, B.R., Heidland, A., and Marzocco, S. (2022). Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105354"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hsu, C.N., and Tain, Y.L. (2022). Chronic Kidney Disease and Gut Microbiota: What Is Their Connection in Early Life?. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073954"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zheng, Z., Xu, Y., Kr\u00fcgel, U., Schaefer, M., Grune, T., N\u00fcrnberg, B., K\u00f6hler, M.B., Gollasch, M., Tsvetkov, D., and Mark\u00f3, L. (2022). In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126870"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Carullo, N., Fabiano, G., D\u2019Agostino, M., Zicarelli, M.T., Musolino, M., Presta, P., Michael, A., Andreucci, M., Bolignano, D., and Coppolino, G. (2023). New Insights on the Role of Marinobufagenin from Bench to Bedside in Cardiovascular and Kidney Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311186"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1053\/j.ajkd.2004.01.009","article-title":"Achievement of target blood pressure levels in chronic kidney disease: A salty question?","volume":"43","author":"Minutolo","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liu, J., Shelton, E.L., Crescenzi, R., Colvin, D.C., Kirabo, A., Zhong, J., Delpire, E.J., Yang, H.C., and Kon, V. (2022). Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031428"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/IJNRD.S319991","article-title":"Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia","volume":"14","author":"Deme","year":"2021","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00467-009-1427-z","article-title":"Inflammation and cachexia in chronic kidney disease","volume":"25","author":"Cheung","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mak, R.H., Gunta, S., Oliveira, E.A., and Cheung, W.W. (2022). Growth Hormone Improves Adipose Tissue Browning and Muscle Wasting in Mice with Chronic Kidney Disease-Associated Cachexia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315310"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mendes, S., Leal, D.V., Baker, L.A., Ferreira, A., Smith, A.C., and Viana, J.L. (2023). The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076017"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sovatzidis, A., Chatzinikolaou, A., Fatouros, I.G., Panagoutsos, S., Draganidis, D., Nikolaidou, E., Avloniti, A., Michailidis, Y., Mantzouridis, I., and Batrakoulis, A. (2020). Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in Patients with Chronic Kidney Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9090868"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12363\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:24:35Z","timestamp":1760127875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/24\/15\/12363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":21,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["ijms241512363"],"URL":"https:\/\/doi.org\/10.3390\/ijms241512363","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]}}}