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{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Antimicrobial resistance is a silent pandemic considered a public health concern worldwide. Strategic therapies are needed to replace antibacterials that are now ineffective. One approach entails the use of well-known antibacterials along with adjuvants that possess non-antibiotic properties but can extend the lifespan and enhance the effectiveness of the treatment, while also improving the suppression of resistance. In this regard, a group of uniform materials based on organic salts (GUMBOS) presents an alternative to this problem allowing the combination of antibacterials with adjuvants. Fluoroquinolones are a family of antibacterials used to treat respiratory and urinary tract infections with broad-spectrum activity. Ciprofloxacin and moxifloxacin-based GUMBOS were synthesized via anion exchange reactions with lithium and sodium salts. Structural characterization, thermal stability and octanol\/water partition ratios were evaluated. The antibacterial profiles of most GUMBOS were comparable to their cationic counterparts when tested against Gram-positive S. aureus and Gram-negative E. coli, except for deoxycholate anion, which demonstrated the least effective antibacterial activity. Additionally, some GUMBOS were less cytotoxic to L929 fibroblast cells and non-hemolytic to red blood cells. Therefore, these agents exhibit promise as an alternative approach to combining drugs for treating infections caused by resistant bacteria.<\/jats:p>","DOI":"10.3390\/ijms242115714","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:01:08Z","timestamp":1698555668000},"page":"15714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-4244","authenticated-orcid":false,"given":"F\u00e1bio M. S.","family":"Costa","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Pharmacy, Department of Chemical Sciences, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-8190","authenticated-orcid":false,"given":"Andreia","family":"Granja","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Pharmacy, Department of Chemical Sciences, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-0544","authenticated-orcid":false,"given":"Roc\u00edo L.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA"},{"name":"Department of Chemistry and Biochemistry, Georgia Southern University, Statesboro, GA 30458, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-7653","authenticated-orcid":false,"given":"Isiah M.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA"},{"name":"Department of Chemistry, Cincinnati University, Cincinnati, OH 45221, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-2835","authenticated-orcid":false,"given":"Salette","family":"Reis","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Pharmacy, Department of Chemical Sciences, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal"}]},{"given":"Marieta L. C.","family":"Passos","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Pharmacy, Department of Chemical Sciences, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-1741","authenticated-orcid":false,"given":"M. L\u00facia M. F. S.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Laboratory of Applied Pharmacy, Department of Chemical Sciences, Faculty of Pharmacy, Porto University, Rua de Jorge Viterbo Ferreira, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13756-017-0208-x","article-title":"The threat of antimicrobial resistance in developing countries: Causes and control strategies","volume":"6","author":"Ayukekbong","year":"2017","journal-title":"Antimicrob. Resist. Infect. 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