{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:39:24Z","timestamp":1773967164205,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["PTDC\/BIM ONC\/7121\/2014"],"award-info":[{"award-number":["PTDC\/BIM ONC\/7121\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology (FCT)","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-016822"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016822"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CENTRO 2020 and LISBOA 2020","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"CENTRO 2020 and LISBOA 2020","award":["UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/00709\/2020"]}]},{"name":"CENTRO 2020 and LISBOA 2020","award":["PTDC\/BIM ONC\/7121\/2014"],"award-info":[{"award-number":["PTDC\/BIM ONC\/7121\/2014"]}]},{"name":"CENTRO 2020 and LISBOA 2020","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}]},{"name":"CENTRO 2020 and LISBOA 2020","award":["POCI-01-0145-FEDER-016822"],"award-info":[{"award-number":["POCI-01-0145-FEDER-016822"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. Numerous preclinical investigations evaluating resveratrol\u2019s anti-tumor impact in animal models of glioma have been reported; however, the variety of experimental circumstances and results have prevented conclusive findings about resveratrol\u2019s effectiveness. Several databases were searched during May 2023, ten publications were identified, satisfying the inclusion criteria, that assess the effects of resveratrol in murine glioma-bearing xenografts. To determine the efficacy of resveratrol, tumor volume and animal counts were retrieved, and the data were then subjected to a random effects meta-analysis. The influence of different experimental conditions and publication bias on resveratrol efficacy were evaluated. Comparing treated to untreated groups, resveratrol administration decreased the tumor volume. Overall, the effect\u2019s weighted standardized difference in means was \u22122.046 (95%CI: \u22123.156 to \u22120.936; p-value &lt; 0.001). The efficacy of the treatment was observed for animals inoculated with both human glioblastoma or rat glioma cells and for different modes of resveratrol administration. The combined administration of resveratrol and temozolomide was more effective than temozolomide alone. Reducing publication bias did not change the effectiveness of resveratrol treatment. The findings suggest that resveratrol slows the development of tumors in animal glioma models.<\/jats:p>","DOI":"10.3390\/ijms242316597","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:54:37Z","timestamp":1700625277000},"page":"16597","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-6522","authenticated-orcid":false,"given":"\u00c2ngelo","family":"Lu\u00eds","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"},{"name":"Grupo de Revis\u00f5es Sistem\u00e1ticas (GRUBI), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}]},{"given":"Helena","family":"Marcelino","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-0853","authenticated-orcid":false,"given":"Fernanda","family":"Domingues","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-4607","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Grupo de Revis\u00f5es Sistem\u00e1ticas (GRUBI), Faculdade de Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Matem\u00e1tica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"},{"name":"Centro de Matem\u00e1tica e Aplica\u00e7\u00f5es (CMA-UBI), Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"given":"Jos\u00e9 Francisco","family":"Cascalheira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias, Universidade da Beira Interior, Rua Marqu\u00eas D\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s43018-020-00150-z","article-title":"Single-cell analyses reveal YAP\/TAZ as regulators of stemness and cell plasticity in glioblastoma","volume":"2","author":"Castellan","year":"2021","journal-title":"Nat. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.addr.2021.01.012","article-title":"Frontiers in the treatment of glioblastoma: Past, present and emerging","volume":"171","author":"Janjua","year":"2021","journal-title":"Adv. Drug Deliv. 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