{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T14:40:42Z","timestamp":1769352042096,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["404938\/2016-7"],"award-info":[{"award-number":["404938\/2016-7"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["APQ-03585-16"],"award-info":[{"award-number":["APQ-03585-16"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["4465656\/2014-5"],"award-info":[{"award-number":["4465656\/2014-5"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["RED-00570-16"],"award-info":[{"award-number":["RED-00570-16"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES) and Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","award":["404938\/2016-7"],"award-info":[{"award-number":["404938\/2016-7"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES) and Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","award":["APQ-03585-16"],"award-info":[{"award-number":["APQ-03585-16"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES) and Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","award":["4465656\/2014-5"],"award-info":[{"award-number":["4465656\/2014-5"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES) and Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","award":["RED-00570-16"],"award-info":[{"award-number":["RED-00570-16"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Medicina Regenerativa (INCT-Regenera)","award":["404938\/2016-7"],"award-info":[{"award-number":["404938\/2016-7"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Medicina Regenerativa (INCT-Regenera)","award":["APQ-03585-16"],"award-info":[{"award-number":["APQ-03585-16"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Medicina Regenerativa (INCT-Regenera)","award":["4465656\/2014-5"],"award-info":[{"award-number":["4465656\/2014-5"]}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Medicina Regenerativa (INCT-Regenera)","award":["RED-00570-16"],"award-info":[{"award-number":["RED-00570-16"]}]},{"name":"Rede Mineira de Nanomedicina Teran\u00f3stica\/FAPEMIG","award":["404938\/2016-7"],"award-info":[{"award-number":["404938\/2016-7"]}]},{"name":"Rede Mineira de Nanomedicina Teran\u00f3stica\/FAPEMIG","award":["APQ-03585-16"],"award-info":[{"award-number":["APQ-03585-16"]}]},{"name":"Rede Mineira de Nanomedicina Teran\u00f3stica\/FAPEMIG","award":["4465656\/2014-5"],"award-info":[{"award-number":["4465656\/2014-5"]}]},{"name":"Rede Mineira de Nanomedicina Teran\u00f3stica\/FAPEMIG","award":["RED-00570-16"],"award-info":[{"award-number":["RED-00570-16"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["404938\/2016-7"],"award-info":[{"award-number":["404938\/2016-7"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["APQ-03585-16"],"award-info":[{"award-number":["APQ-03585-16"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["4465656\/2014-5"],"award-info":[{"award-number":["4465656\/2014-5"]}]},{"name":"FCT\/MCTES (PIDDAC)","award":["RED-00570-16"],"award-info":[{"award-number":["RED-00570-16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer is one of the deadliest diseases worldwide and has been responsible for millions of deaths. However, developing a satisfactory smart multifunctional material combining different strategies to kill cancer cells poses a challenge. This work aims at filling this gap by developing a composite material for cancer treatment through hyperthermia and drug release. With this purpose, magnetic nanoparticles were coated with a polymer matrix consisting of poly (L-co-D,L lactic acid-co-trimethylene carbonate) and a poly(ethylene oxide)\u2013poly(propylene oxide)\u2013poly(ethylene oxide) triblock copolymer. High-resolution transmission electron microscopy and selected area electron diffraction confirmed magnetite to be the only iron oxide in the sample. Cytotoxicity and heat release assays on the hybrid nanoparticles were performed here for the first time. The heat induction results indicate that these new magnetic hybrid nanoparticles are capable of increasing the temperature by more than 5 \u00b0C, the minimal temperature rise required for being effectively used in hyperthermia treatments. The biocompatibility assays conducted under different concentrations, in the presence and in the absence of an external alternating current magnetic field, did not reveal any cytotoxicity. Therefore, the overall results indicate that the investigated hybrid nanoparticles have a great potential to be used as carrier systems for cancer treatment by hyperthermia.<\/jats:p>","DOI":"10.3390\/ijms25010493","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T11:19:21Z","timestamp":1703848761000},"page":"493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Heating Capacity and Biocompatibility of Hybrid Nanoparticles for Magnetic Hyperthermia Treatment"],"prefix":"10.3390","volume":"25","author":[{"given":"Aline Alexandrina","family":"Gomes","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas (ICEB), Universidade Federal de Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil"}]},{"given":"Thalita Marcolan","family":"Valverde","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Vagner de Oliveira","family":"Machado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas (ICEB), Universidade Federal de Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-7132","authenticated-orcid":false,"given":"Emanueli","family":"do Nascimento da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas (ICEB), Universidade Federal de Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2853-7638","authenticated-orcid":false,"given":"Daniele Alves","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de F\u00edsica Aplicada, Centro de Desenvolvimento da Tecnologia Nuclear (CDTN\/CNEN), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Fernanda de Paula","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de F\u00edsica Aplicada, Centro de Desenvolvimento da Tecnologia Nuclear (CDTN\/CNEN), Belo Horizonte 31270-901, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-8662","authenticated-orcid":false,"given":"Erico Tadeu Fraga","family":"Freitas","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931-1295, USA"}]},{"given":"Jos\u00e9 Domingos","family":"Ardisson","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de F\u00edsica Aplicada, Centro de Desenvolvimento da Tecnologia Nuclear (CDTN\/CNEN), Belo Horizonte 31270-901, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-2809","authenticated-orcid":false,"given":"Jos\u00e9 Maria da Fonte","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia de Materiais e Cer\u00e2mica (CICECO), Universidade de Aveiro (UA), 3810193 Aveiro, Portugal"}]},{"given":"Junnia Alvarenga de Carvalho","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Eliza Rocha","family":"Gomes","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Caio Fabrini","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Alfredo Miranda de","family":"Goes","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"given":"Rosana Zacarias","family":"Domingues","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas (ICEx), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-5072","authenticated-orcid":false,"given":"\u00c2ngela Le\u00e3o","family":"Andrade","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Ci\u00eancias Exatas e Biol\u00f3gicas (ICEB), Universidade Federal de Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125014","DOI":"10.1088\/2053-1591\/aae11b","article-title":"Development of a novel nano-biomaterial for biomedical applications","volume":"5","author":"Machado","year":"2018","journal-title":"Mater. Res. Express"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"van Herk, A., and Landfester, K. (2010). Hybrid Latex Particles. Advances in Polymer Science, Springer.","DOI":"10.1007\/978-3-642-16060-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/app.38840","article-title":"Encapsulation of magnetic nickel nanoparticles via inverse miniemulsion polymerization","volume":"129","author":"Romio","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1002\/macp.201300329","article-title":"Magnetic polymer\/nickel hybrid nanoparticles via miniemulsion polymerization","volume":"214","author":"Staudt","year":"2013","journal-title":"Macromol. Chem. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0378-5173(89)90281-0","article-title":"Nanocapsule formation by interfacial polymer deposition following solvent displacement","volume":"55","author":"Fessi","year":"1989","journal-title":"Int. J. Pharm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.colsurfa.2016.12.029","article-title":"Effect of process and formulation parameters on polycaprolactone nanoparticles prepared by solvent displacement","volume":"516","author":"Badria","year":"2017","journal-title":"Colloids Surf. A."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0005-2736(89)90399-4","article-title":"Relationship of hyperthermia-induced hemolysis of human erythrocytes to the thermal denaturation of membrane proteins","volume":"980","author":"Lepock","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18317","DOI":"10.1021\/acsomega.9b02427","article-title":"Alternative cutaneous substitutes based on poly(L-co-D,L-lactic acid-co-trimethylene carbonate) with Schinus terebinthifolius raddi extract designed for skin healing","volume":"4","author":"Komatsu","year":"2019","journal-title":"ACS Omega"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4322\/polimeros.2014.021","article-title":"Membrana de PLDLA-TMC como protetor na regenera\u00e7\u00e3o do tend\u00e3o calc\u00e2neo. Estudo in vivo em Coelhos","volume":"24","author":"Duek","year":"2014","journal-title":"Polim. Cienc. Tecnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1007\/s00289-018-2283-4","article-title":"In vitro and in vivo studies on devices of poly(l-co-d,l lactic acid)-co-TMC for bone repair","volume":"75","author":"Motta","year":"2018","journal-title":"Polym. Bull."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0006-2952(93)90668-M","article-title":"Mechanism of poloxamer 407-induced hypertriglyceridemia in the rat","volume":"46","author":"Johnston","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10751-019-1558-y","article-title":"A novel hybrid nanoparticle based on Fe3O4\/TMAOH\/poly(L-co-D,L lactic acid-co-trimethylene carbonate) prepared through the solvent displacement method","volume":"240","author":"Machado","year":"2019","journal-title":"Hyperfine Interac."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"126706","DOI":"10.1016\/j.colsurfa.2021.126706","article-title":"Preparation of hybrid nanocomposite particles for medical practices","volume":"624","author":"Machado","year":"2021","journal-title":"Colloids Surf. A."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111218","DOI":"10.1016\/j.colsurfb.2020.111218","article-title":"Biodegradable poly (lactic acid-co-trimethylene carbonate)\/chitosan microsphere scaffold with shape-memory effect for bone tissue engineering","volume":"195","author":"Hu","year":"2020","journal-title":"Colloids Surf. B."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1039\/C5CE01014D","article-title":"Fundamental growth principles of colloidal metal nanoparticles\u2014A new perspective","volume":"17","author":"Polte","year":"2015","journal-title":"CrystEngComm"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.mseb.2012.01.003","article-title":"Synthesis and characterization of magnetite nanoparticles via the chemical co-precipitation method","volume":"177","author":"Petcharoen","year":"2012","journal-title":"Mater. Sci. Eng. B"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.3390\/molecules18077533","article-title":"Synthesis, surface modification and characterisation of biocompatible magnetic iron oxide nanoparticles for biomedical applications","volume":"18","author":"Mahdavi","year":"2013","journal-title":"Molecules"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.15376\/biores.6.4.5110-5120","article-title":"Optimized conditions for graft copolymerization of poly(acrylamide) onto rubberwood fibre","volume":"6","author":"Nadi","year":"2011","journal-title":"BioResources"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"012190","DOI":"10.1088\/1742-6596\/1013\/1\/012190","article-title":"The impact of synthesis temperature on magnetite nanoparticles size synthesized by co-precipitation method","volume":"1013","author":"Saragi","year":"2018","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1021\/jp071299b","article-title":"Effect of digestion time and alkali addition rate on physical properties of magnetite nanoparticles","volume":"111","author":"Gnanaprakash","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1166\/jnn.2018.15458","article-title":"Role of particle\u2013particle interaction towards effective interpretation of z-average and particle size distributions from dynamic light scattering (DLS) Analysis","volume":"18","author":"Yeap","year":"2018","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1039\/C4AY01203H","article-title":"Comparison of different characterization methods for nanoparticle dispersions before and after aerosolization","volume":"6","author":"Fissan","year":"2014","journal-title":"Anal. Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.1038\/srep07107","article-title":"The role of the helper lipid on the DNA transfection efficiency of lipopolyplex formulations","volume":"4","author":"Du","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21496","DOI":"10.1016\/j.ceramint.2020.05.249","article-title":"Magnetically induced heating by iron oxide nanoparticles dispersed in liquids of different viscosities","volume":"46","author":"Andrade","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/1556-276X-6-383","article-title":"The influence of colloidal parameters on the specific power absorption of PAA-coated magnetite nanoparticles","volume":"6","author":"Goya","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20337","DOI":"10.1016\/j.ceramint.2018.08.022","article-title":"Evaluation of in vitro and in vivo biocompatibility and structure of cobalt-releasing sol-gel bioactive glass","volume":"44","author":"Barrioni","year":"2018","journal-title":"Ceram. Int."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Repar, N., Jovicic, E.J., Kump, A., Birarda, G., Vaccari, L., Erman, A., Kralj, S., Nemec, S., Petan, T., and Drobne, D. (2022). Oleic acid protects endothelial cells from silica-coated superparamagnetic iron oxide nanoparticles (spions)-induced oxidative stress and cell death. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136972"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jconrel.2010.06.010","article-title":"In-vivo tumor targeting of pluronic-based nano-carriers","volume":"147","author":"Kim","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10Q905","DOI":"10.1063\/1.1850855","article-title":"Magnetic studies of iron oxide nanoparticles coated with oleic acid and Pluronic block copolymer","volume":"97","author":"Morales","year":"2005","journal-title":"J. Appl. Phys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1016\/j.biomaterials.2008.07.004","article-title":"Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging","volume":"29","author":"Jain","year":"2008","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"285604","DOI":"10.1088\/0957-4484\/18\/28\/285604","article-title":"Preparation and antibacterial activity of Fe3O4@Ag nanoparticles","volume":"18","author":"Gong","year":"2007","journal-title":"Nanotechnology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2147\/IJN.S10458","article-title":"Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells","volume":"5","author":"Wu","year":"2010","journal-title":"Int. J. Nanomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1016\/S0142-9612(03)00237-0","article-title":"Dextran and albumin derivatised iron oxide nanoparticles: Influence on fibroblasts in vitro","volume":"24","author":"Berry","year":"2003","journal-title":"Biomaterials"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00204-014-1267-x","article-title":"Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses","volume":"89","author":"Luo","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.phrs.2019.01.005","article-title":"A thermoresponsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy","volume":"143","author":"Mirrahimi","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.addr.2009.11.006","article-title":"Targeted hyperthermia using metal nanoparticles","volume":"62","author":"Cherukuri","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1039\/C7NR00810D","article-title":"Unraveling viscosity effects on the hysteresis losses of magnetic nanocubes","volume":"9","author":"Cabrera","year":"2017","journal-title":"Nanoscale"},{"key":"ref_39","unstructured":"(2009). Standard Practice for Assessment of Hemolytic Properties of Materials; Annual Book of ASTM Standards. Committee F04 Medical and Surgical Materials and Devices, Subcommittee F04.16 Biocompatibility Test Methods (Standard No. ASTM F-756)."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1590\/S1516-14392014005000067","article-title":"Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate","volume":"17","author":"Motta","year":"2014","journal-title":"Mater. Res."},{"key":"ref_41","unstructured":"Vogel, A.I. (1962). A Text Book of Quantitative Inorganic Analysis, Longman."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tiv.2019.02.011","article-title":"In vitro toxicity assessment of zinc and nickel ferrite nanoparticles in human erythrocytes and peripheral blood mononuclear cell","volume":"57","author":"Tavarez","year":"2019","journal-title":"Toxicol. In Vitro"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/493\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:44:28Z","timestamp":1760132668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/1\/493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["ijms25010493"],"URL":"https:\/\/doi.org\/10.3390\/ijms25010493","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]}}}