{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:25:20Z","timestamp":1771467920895,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a proton pump inhibitor\u2014PPI) in resolving heartburn, reflux, and other symptoms and complications resulting from gastroesophageal reflux disease (GERD). The study followed PRISMA 2020 and was registered in PROSPERO (CRD42020206513). The search strategy used MeSH and free terms appropriately adapted for each database. Only randomized clinical trials (RCTs) were included. The Cochrane tool (RoB 2.0) was used to assess the risk of bias, and the certainty of evidence was rated using GRADE. Ten RCTs were included. Dexlansoprazole outperformed the placebo and other PPIs in the resolution of heartburn and reflux symptoms in patients with GERD, with benefits during and after treatment, especially in those with moderate and severe symptoms. The meta-analyses indicated that dexlansoprazole at doses of 30 and 60 mg had more 24 h heartburn-free days and nights compared to the placebo medications; no difference was reported between dexlansoprazole at doses of 30 and 60 mg in heartburn-free nights. A low bias risk and a moderate certainty of evidence were observed. This review confirms the therapeutic effect of dexlansoprazole (placebo-controlled) and its improvements in GERD symptoms compared to another PPI. However, the interpretation of the results should be carried out cautiously due to the small number of included studies and other reported limitations.<\/jats:p>","DOI":"10.3390\/ijms25021247","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T08:58:13Z","timestamp":1705654693000},"page":"1247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"25","author":[{"given":"Gabriel Pereira","family":"Nunes","sequence":"first","affiliation":[{"name":"Department of Restorative and Preventive Dentistry, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16018-805, Brazil"},{"name":"Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, 4160-007 Porto, Portugal"},{"name":"Associated Laboratory for Green Chemistry\u2014LAQV\/REQUIMTE, University of Porto, 4050-453 Porto, Portugal"}]},{"given":"Thayn\u00e1 Cerqueira","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, Brazil"}]},{"given":"Jo\u00e3o V\u00edtor Silveira","family":"Marciano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-7137","authenticated-orcid":false,"given":"Alexandre Henrique","family":"dos Reis-Prado","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil"},{"name":"Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48104, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-2819","authenticated-orcid":false,"given":"Tulio Morandin","family":"Ferrisse","sequence":"additional","affiliation":[{"name":"Department of Diagnosis, Surgery and Oral Medicine, School of Dentistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-385, Brazil"}]},{"given":"Evandro Barbosa","family":"dos Anjos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-9574","authenticated-orcid":false,"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, 4160-007 Porto, Portugal"},{"name":"Associated Laboratory for Green Chemistry\u2014LAQV\/REQUIMTE, University of Porto, 4050-453 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00464-022-09817-3","article-title":"Multi-society consensus conference and guideline on the treatment of gastroesophageal reflux disease (GERD)","volume":"37","author":"Slater","year":"2023","journal-title":"Surg. 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