{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:28:04Z","timestamp":1764937684633,"version":"build-2065373602"},"reference-count":109,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology","award":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"]}]},{"name":"Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT)","award":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"]}]},{"name":"CICS-UBI projects","award":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/04923\/2020","UIDB\/00709\/2020","UIDP\/00709\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. Substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for their ability to induce weight gain, often accompanied by hormonal alterations that can adversely impact male fertility. Indeed, research has supplied evidence underscoring the crucial role of obesogens and therapeutic agents in the normal functioning of the male reproductive system. Notably, sperm count and various semen parameters have been closely linked to a range of environmental and nutritional factors, including chemicals and pharmacological agents exhibiting obesogenic properties. This review aimed to explore studies focused on analyzing male fertility parameters, delving into the intricacies of sperm quality, and elucidating the direct and adverse effects that pharmacological agents may have on these aspects.<\/jats:p>","DOI":"10.3390\/ijms25042324","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T11:19:01Z","timestamp":1707995941000},"page":"2324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health"],"prefix":"10.3390","volume":"25","author":[{"given":"Caio","family":"Mascarenhas","sequence":"first","affiliation":[{"name":"School of Health, Polytechnic Institute of Guarda, 6300-035 Guarda, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-7414","authenticated-orcid":false,"given":"Ana C. A.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Science and Technology, University of \u00c9vora, 7006-554 \u00c9vora, Portugal"},{"name":"Comprehensive Health Research Centre (CHRC), University of \u00c9vora, 7000-671 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-2051","authenticated-orcid":false,"given":"Lu\u00eds","family":"Rato","sequence":"additional","affiliation":[{"name":"School of Health, Polytechnic Institute of Guarda, 6300-035 Guarda, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s40572-014-0026-8","article-title":"The Obesogen Hypothesis: Current Status and Implications for Human Health","volume":"1","author":"Heindel","year":"2014","journal-title":"Curr. 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