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This study investigated the development of magnetic nanoparticles coated with silica and incorporating the anti-inflammatory drug naproxen, aimed at multifunctional biomedical applications. The synthesized nanoparticles were characterized using various techniques that confirmed the presence of magnetite and the formation of a silica-rich bioactive glass (BG) layer. In vitro studies demonstrated that the nanoparticles exhibited bioactive properties, forming an apatite surface layer when immersed in simulated body fluid, and biocompatibility with bone cells, with good viability and alkaline phosphatase activity. Naproxen, either free or encapsulated, reduced nitric oxide production, an inflammatory marker, while the BG coating alone did not show anti-inflammatory effects in this study. 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material","volume":"23","author":"Arcos","year":"2002","journal-title":"Biomaterials"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jab.770020403","article-title":"An investigation of bioactive glass powders by sol\u2013gel proccesing","volume":"2","author":"Li","year":"1991","journal-title":"J. Appl. Biomater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/cm9911114","article-title":"Surface and chemical study of SiO2 \u2022 P2O5 \u2022 CaO \u2022 (MgO) bioactive glasses","volume":"12","author":"Balas","year":"2000","journal-title":"Chem. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1097-4636(200007)51:1<23::AID-JBM4>3.0.CO;2-B","article-title":"Evolution of porosity during in vitro hydroxycarbonate apatite growth in sol\u2013gel glasses","volume":"51","author":"Arcos","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.msec.2015.09.002","article-title":"Acute toxicity and in vivo biodistribution of monodispersed mesoporous bioactive glass spheres in intravenously exposed mice","volume":"58","author":"Mao","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_6","first-page":"259","article-title":"A review of bioactive materials and chronic wounds","volume":"85","author":"Plotner","year":"2010","journal-title":"Cutis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1016\/j.actbio.2013.02.014","article-title":"Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect","volume":"9","author":"Li","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lewandowska-Lancucka, J., Fiejdasz, S., Rodzik, L., Koziel, M., and Nowakowska, M. (2015). Bioactive hydrogel-nanosilica hybrid materials: A potential injectable scaffold for bone tissue engineering. Biomed. Mater., 10.","DOI":"10.1088\/1748-6041\/10\/1\/015020"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2000537","DOI":"10.1002\/adfm.202000537","article-title":"Antifungal-inbuilt metal\u2013organic-frameworks eradicate Candida albicans biofilms","volume":"30","author":"Su","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101198","DOI":"10.1016\/j.nantod.2021.101198","article-title":"In situ oxidation-regulated self-assembly of peptides into transformable scaffolds for cascade therapy","volume":"38","author":"Song","year":"2021","journal-title":"Nano Today"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Iovene, A., Zhao, Y., Wang, S., and Amoako, K. (2021). Bioactive polymeric materials for the advancement of regenerative medicine. J. Funct. 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Solids"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1208\/s12249-017-0931-x","article-title":"Theoretical and experimental studies of the controlled release of tetracycline incorporated into bioactive glasses","volume":"19","author":"Andrade","year":"2018","journal-title":"AAPS PharmSciTech."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1021\/acsami.1c16859","article-title":"Magnetic biohybrid microrobot multimers based on chlorella cells for enhanced targeted drug delivery","volume":"14","author":"Gong","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/jbm.a.35639","article-title":"History and trends of bioactive glass-ceramics","volume":"104","author":"Montazerian","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jeurceramsoc.2020.08.005","article-title":"Development of novel alumina-containing bioactive glass-ceramics in the CaO-MgO-SiO2 system as candidates for dental implant applications","volume":"41","author":"Dimitriadis","year":"2021","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.2174\/1381612821666150917093543","article-title":"Current status of magnetite-based core@shell structures for diagnosis and therapy in oncology","volume":"21","author":"Andrade","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10751-012-0681-9","article-title":"Preparation of composite with silica-coated nanoparticles of iron oxide spinels for applications based on magnetically induced hyperthermia","volume":"218","author":"Andrade","year":"2013","journal-title":"Hyperfine Interact."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actbio.2018.11.013","article-title":"Glass-ceramics for cancer treatment: So close, or yet so far?","volume":"83","author":"Miola","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.drudis.2018.05.027","article-title":"Bioactive glasses entering the mainstream","volume":"23","author":"Kargozar","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1023\/A:1026346109737","article-title":"Effect of ferrite thermoseeds on destruction of carcinoma cells under alternating magnetic field","volume":"38","author":"Lee","year":"2003","journal-title":"J. Mater. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0142-9612(97)00067-7","article-title":"Bioactivity of ferrimagnetic glass-ceramics in the system FeO-Fe2O3-CaO-SiO2","volume":"18","author":"Ebisawa","year":"1997","journal-title":"Biomoterials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.ijrobp.2015.12.361","article-title":"Hyperthermia and radiation therapy in locoregional recurrent breast cancers: A systematic review and meta-analysis","volume":"94","author":"Datta","year":"2016","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/02656736.2015.1099746","article-title":"Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis","volume":"32","author":"Datta","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1021\/acsanm.1c01903","article-title":"Review of functionalized nanomaterials for photothermal therapy of cancers","volume":"4","author":"Bian","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_28","first-page":"437","article-title":"In-vitro comparison of cytotoxicity of two bioactive glasses in micropowder and nanopowder forms","volume":"12","author":"Rismanchian","year":"2013","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1800507","DOI":"10.1002\/ppsc.201800507","article-title":"Enhanced physiological stability and long-term toxicity\/biodegradation in vitro\/in vivo of monodispersed glycerolphosphate-functionalized bioactive glass nanoparticles","volume":"36","author":"Xue","year":"2019","journal-title":"Part. Part. Syst. Charact."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhou, G., and Groth, T. (2018). Host responses to biomaterials and anti-inflammatory design-a brief review. Macromol. Biosci., 18.","DOI":"10.1002\/mabi.201800112"},{"key":"ref_31","unstructured":"Yu, T., Tutwiler, V.J., and Spiller, K. (2015). Biomaterials in Regenerative Medicine and the Immune System, Springer International Publishing."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: Master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Patrono, C. (2016). Cardiovascular effects of nonsteroidal antiinflammatory drugs. Curr. Cardiol. Rep., 18.","DOI":"10.1007\/s11886-016-0702-4"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.colsurfb.2010.11.014","article-title":"Naproxen\u2013eudragit\u00ae RS100 nanoparticles: Preparation and physicochemical characterization","volume":"83","author":"Adibkia","year":"2011","journal-title":"Colloids Surf. B"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.colsurfb.2016.05.064","article-title":"The design of naproxen solid lipid nanoparticles to target skin layers","volume":"145","author":"Akbari","year":"2016","journal-title":"Colloids Surf. B"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112024","DOI":"10.1016\/j.msec.2021.112024","article-title":"Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways","volume":"124","author":"Schwartz","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1039\/c3tb21304h","article-title":"Double entrapment of growth factors by nanoparticles loaded into polyelectrolyte multilayer films","volume":"2","author":"Vrana","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wewers, M., Czyz, S., Finke, J.H., John, E., Van Eerdenbrugh, B., Juhnke, M., Bunjes, H., and Kwade, A. (2020). Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12040363"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116192","DOI":"10.1016\/j.taap.2022.116192","article-title":"Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb\/c mice","volume":"452","author":"Razzaq","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"133295","DOI":"10.1016\/j.colsurfa.2024.133295","article-title":"Metal organic framework-loaded biohybrid magnetic microrobots for enhanced antibacterial treatment","volume":"685","author":"Gu","year":"2024","journal-title":"Colloids Surf. A"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fchem.2019.00497","article-title":"Toward highly dispersed mesoporous bioactive glass nanoparticles with high Cu concentration using Cu\/ascorbic acid complex as precursor","volume":"7","author":"Zheng","year":"2019","journal-title":"Front. Chem."},{"key":"ref_42","first-page":"314","article-title":"Genotoxicity effects of nano bioactive glass and Novabone bioglass on gingival fibroblasts using single cell gel electrophoresis (comet assay): An in vitro study","volume":"9","author":"Tavakoli","year":"2012","journal-title":"Dent. Res. J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Borges, R., Pelosine, A.M., de Souza, A.C.S., Machado, J., Justo, G.Z., Gamarra, L.F., and Marchi, J. (2022). Bioactive glasses as carriers of cancer-targeted drugs: Challenges and opportunities in bone cancer treatment. Materials, 15.","DOI":"10.3390\/ma15249082"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"21496","DOI":"10.1016\/j.ceramint.2020.05.249","article-title":"Magnetically induced heating by iron oxide nanoparticles dispersed in liquids of different viscosities","volume":"46","author":"Andrade","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1151-2916.1998.tb02540.x","article-title":"Bioceramics","volume":"81","author":"Hench","year":"1998","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1103\/PhysRev.99.1727","article-title":"Infrared Spectra of Ferrites","volume":"99","author":"Waldron","year":"1955","journal-title":"Phys. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/S1386-1425(02)00019-7","article-title":"Vibrational study of (CH3)4NSbCl6 and [(CH3)4N]2SiF6","volume":"58","author":"Ouasri","year":"2002","journal-title":"Spectrochim. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/(SICI)1097-4636(19980615)40:4<640::AID-JBM16>3.0.CO;2-J","article-title":"Vibrational spectroscopic study of tetracalcium phosphate in pure polycrystalline form and as a constituent of a self-setting bone cement","volume":"40","author":"Posset","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jnoncrysol.2003.09.013","article-title":"FTIR and XPS studies of bioactive silica based glasses","volume":"332","author":"Serra","year":"2003","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10971-006-7780-5","article-title":"Characterization and application of Fe3O4\/SiO2 nanocomposites","volume":"39","author":"Du","year":"2006","journal-title":"J. Sol.-Gel. Sci. Techn."},{"key":"ref_51","first-page":"1221","article-title":"Influence of the non-brindging oxygen groups on the bioactivity of silicate glasses","volume":"13","author":"Serra","year":"2002","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jbm.a.10503","article-title":"A new quantitative method to evaluate the in vitro bioactivity of melt and sol-gel-derived silicate glasses","volume":"65","author":"Arcos","year":"2003","journal-title":"J. Biomed. Mater. Res.-Part A"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4028\/www.scientific.net\/KEM.631.36","article-title":"Combustion Synthesis of 58S Bioglass Using Sol-Gel Self-Propagating Combustion Method","volume":"631","author":"Bertran","year":"2014","journal-title":"Key Eng. Mater."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jnoncrysol.2013.08.023","article-title":"Investigating the mechanical durability of bioactive glasses as a function of structure, solubility and incubation time","volume":"380","author":"Li","year":"2013","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_55","unstructured":"Elliott, J.C. (1994). Studies in Inorganic Chemistry, Elsevier."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jnoncrysol.2007.09.007","article-title":"Synthesis and characterization of new SiO2\u2013CaO hollow nanospheres by sol\u2013gel method: Bioactivity of the new system","volume":"354","author":"Pappas","year":"2008","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11095-011-0539-x","article-title":"Influence of solvent composition on the miscibility and physical stability of naproxen\/PVP K 25 solid dispersions prepared by cosolvent spray-drying","volume":"29","author":"Paudel","year":"2012","journal-title":"Pharm. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/0104-1428.1636","article-title":"S\u00edntese e caracteriza\u00e7\u00e3o de novos copol\u00edmeros fosforilados","volume":"25","author":"Novack","year":"2015","journal-title":"Polim. Cienc. Tecnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1700066","DOI":"10.1002\/masy.201700066","article-title":"Preparation, characterization, and biological activity against artemia salina of news copolymer PMMA-g-PEG derivatives incorporated with fluconazole","volume":"378","author":"Silveira","year":"2018","journal-title":"Macromol. Symp."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18340","DOI":"10.1021\/la102845k","article-title":"Synthesis and electrospinning of \u03b5-polycaprolactone-bioactive glass hybrid biomaterials via a sol-gel process","volume":"26","author":"Allo","year":"2010","journal-title":"Langmuir"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jnoncrysol.2009.01.010","article-title":"Structural study of sol\u2013gel silicate glasses by IR and Raman spectroscopies","volume":"355","author":"Aguiar","year":"2009","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1021\/ma00192a011","article-title":"Thermodynamics of hydrogen bonding in polymer blends. 1. The application of association models","volume":"22","author":"Painter","year":"1989","journal-title":"Macromolecules"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sousa, L.R.D., Amparo, T.R., de Souza, G.H.B., Ferraz, A.T., Fonseca, K.S., de Azevedo, A.S., do Nascimento, A.M., Andrade, A.L., Seibert, J.B., and Valverde, T.M. (2023). Anti-Trypanosoma cruzi potential of vestitol isolated from lyophilized red propolis. Molecules, 28.","DOI":"10.3390\/molecules28237812"},{"key":"ref_64","unstructured":"(2009). Biological Evaluation of Medical Devices-Part 5: Tests for In Vitro Cytotoxicity (Standard No. ISO 10993-5)."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1016\/j.biomaterials.2014.06.032","article-title":"Endocytosis of PEGylated nanoparticles accompanied by structural and free energy changes of the grafted polyethylene glycol","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/mp800032f","article-title":"Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution","volume":"5","author":"Dobrovolskaia","year":"2008","journal-title":"Mol. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2265.2001.01082.x","article-title":"Interleukin-6 (IL-6) producing phaeochromocytoma: Direct IL-6 suppression by non-steroidal anti-inflammatory drugs","volume":"54","author":"Shimizu","year":"2001","journal-title":"Clin. Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1016\/j.biomaterials.2014.05.007","article-title":"The influence of lysosomal stability of silver nanomaterials on their toxicity to human cells","volume":"35","author":"Setyawati","year":"2014","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Su, J.Y., Chen, S.H., Chen, Y.P., and Chen, W.C. (2017). Evaluation of magnetic nanoparticle- labeled chondrocytes cultivated on a type II collagen-chitosan\/poly(lactic-co-glycolic) acid biphasic scaffold. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010087"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wen, J., Li, H., Dai, H., Hua, S., Long, X., Li, H., Ivanovski, S., and Xu, C. (2023). Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management. Mater. Today Bio, 19.","DOI":"10.1016\/j.mtbio.2023.100597"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Marchandet, L., Lallier, M., Charrier, C., Baudhuin, M., Ory, B., and Lamoureux, F. (2021). Mechanisms of resistance to conventional therapies for osteosarcoma. Cancers, 13.","DOI":"10.3390\/cancers13040683"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.bjc.6605723","article-title":"Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone","volume":"103","author":"Cumming","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1590\/S0100-40421999000400017","article-title":"Biological functions of nitric oxide","volume":"22","author":"Queiroz","year":"1999","journal-title":"Qu\u00edm. Nova"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1440-1711.2006.01426.x","article-title":"Atrovirinone inhibits pro-inflammatory mediator release from murine macrophages and human whole blood","volume":"84","author":"Syahida","year":"2006","journal-title":"Immunol. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/berh.2001.0196","article-title":"The role of nitric oxide in tissue destruction","volume":"15","author":"Abramson","year":"2001","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/bega.2001.0236","article-title":"COX-1 and COX-2 inhibitors","volume":"15","author":"Hawkey","year":"2001","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1124\/jpet.302.1.138","article-title":"Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages","volume":"302","author":"Kang","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41368-019-0046-1","article-title":"Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp","volume":"11","author":"Zhang","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_79","first-page":"347","article-title":"Biological basis of bone strength: Anatomy, physiology and measurement","volume":"20","author":"Hart","year":"2020","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.biomaterials.2018.09.028","article-title":"Bone physiology as inspiration for tissue regenerative therapies","volume":"185","author":"Lopes","year":"2018","journal-title":"Biomaterials"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.lfs.2016.08.003","article-title":"A novel 3D bone-mimetic scaffold composed of collagen\/MTA\/MWCNT modulates cell migration and osteogenesis","volume":"162","author":"Valverde","year":"2016","journal-title":"Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"111961","DOI":"10.1016\/j.msec.2021.111961","article-title":"Nanohybrid composed of graphene oxide functionalized with sodium hyaluronate accelerates bone healing in the tibia of rats","volume":"123","author":"Dantas","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Yang, J., Wu, J., Guo, Z., Zhang, G., and Zhang, H. (2022). Iron oxide nanoparticles combined with static magnetic fields in bone remodeling. Cells, 11.","DOI":"10.3390\/cells11203298"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1021\/nn5009879","article-title":"Bioactive silica nanoparticles promote osteoblast differentiation through stimulation of autophagy and direct association with LC3 and p62","volume":"8","author":"Ha","year":"2014","journal-title":"ACS Nano"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"122656","DOI":"10.1016\/j.jnoncrysol.2023.122656","article-title":"Study of the manganese and calcium synergetic influence on mesoporous bioactive glass characteristic","volume":"622","author":"Queiroz","year":"2023","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Panseri, S., Cunha, C., D\u2019Alessandro, T., Sandri, M., Russo, A., Giavaresi, G., Marcacci, M., Hung, C.T., and Tampieri, A. (2012). Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: Evaluation in vitro using osteoblast-like cells and in vivo in a bone defect. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038710"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jbm.820240607","article-title":"Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W","volume":"24","author":"Kokubo","year":"1990","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/ten.tec.2012.0412","article-title":"Effects of continuous passaging on mineralization of MC3T3-E1 cells with improved osteogenic culture protocol","volume":"20","author":"Yan","year":"2014","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"16","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-0716-2675-7_26","article-title":"Prussian blue staining to visualize iron oxide nanoparticles","volume":"2566","author":"Bitonto","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Ferraz, F.S., Lopez, J.L., Lacerda, S.M.S.N., Procopio, M.S., Figueiredo, A.F.A., Martins, E.M.N., Guimaraes, P.P.G., Ladeira, L.O., Kitten, G.T., and Dias, F.F. (2020). Biotechnological approach to induce human fibroblast apoptosis using superparamagnetic iron oxide nanoparticles. J. Inorg. Biochem., 206.","DOI":"10.1016\/j.jinorgbio.2020.111017"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and (15 N)-nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4270\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:26:52Z","timestamp":1760106412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":92,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["ijms25084270"],"URL":"https:\/\/doi.org\/10.3390\/ijms25084270","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}