{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T18:31:34Z","timestamp":1774204294849,"version":"3.50.1"},"reference-count":164,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CICS-UBI base funding","award":["2023.03289.BD"],"award-info":[{"award-number":["2023.03289.BD"]}]},{"name":"Foundation for Science and Technology budget","award":["2023.03289.BD"],"award-info":[{"award-number":["2023.03289.BD"]}]},{"name":"CICS-UBI","award":["2023.03289.BD"],"award-info":[{"award-number":["2023.03289.BD"]}]},{"name":"FCT","award":["2023.03289.BD"],"award-info":[{"award-number":["2023.03289.BD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Infertility is recognized globally as a social disease and a growing medical condition, posing a significant challenge to modern reproductive health. Endometriosis, the third-most frequent gynecologic disorder, is one of the most common and intricate conditions that can lead to female infertility. Despite extensive research, the etiology, malignant transformation, and biological therapy of endometriosis remain unknown. Blood and follicular fluid are two matrices that have been carefully studied and can provide insights into women\u2019s health. These matrices are clinically significant because they contain metabolites closely associated with women\u2019s illness stage and reproductive outcomes. Nowadays, the application of metabolomic analysis in biological matrices may be able to predict the outcome of assisted reproductive technologies with greater precision. From a molecular viewpoint on reproductive health, we evaluate and compare the utilization of human follicular fluid and blood as matrices in analysis for diagnostic and assisted reproductive technology (ART) predictors of success for endometriosis patients. In the follicular fluid (FF), plasma, and serum of endometriosis-affected women, researchers identified dysregulations of oxidative stress, upregulation of several immune factors, and aberrations in energy metabolic pathways. The altered signatures negatively correlate with the overall oocyte and embryo quality and fertilization rate.<\/jats:p>","DOI":"10.3390\/ijms25137177","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:58:42Z","timestamp":1719925122000},"page":"7177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Follicular Fluid and Blood Monitorization of Infertility Biomarkers in Women with Endometriosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-348X","authenticated-orcid":false,"given":"Ana Teresa","family":"Brinca","sequence":"first","affiliation":[{"name":"Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-3749","authenticated-orcid":false,"given":"Ana Maria","family":"Peir\u00f3","sequence":"additional","affiliation":[{"name":"Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), Dr. Balmis General University Hospital, 03010 Alicante, Spain"},{"name":"Institute of Bioengineering, Miguel Hern\u00e1ndez University, 03202 Elche, Spain"}]},{"given":"Pilar Matall\u00edn","family":"Evangelio","sequence":"additional","affiliation":[{"name":"Unidad de Reproduccion, Hospital General Universitario de Alicante, 03010 Alicante, Spain"}]},{"given":"Irene","family":"Eleno","sequence":"additional","affiliation":[{"name":"Unidad de Reproduccion, Servicio de Ginecologia y Obstetricia, Hospital General Universitario Dr. Balmis, 03010 Alicante, Spain"}]},{"given":"Antonio Helio","family":"Oliani","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Laboratory, Cova da Beira Local Health Unit, 6200-251 Covilh\u00e3, Portugal"},{"name":"S\u00e3o Jos\u00e9 do Rio Preto School of Medicine, Gynaecology and Obstetrics, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, Brazil"}]},{"given":"Vladimiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Ferticentro\u2014Centro de Estudos de Fertilidade S.A., 3000-316 Coimbra, Portugal"},{"name":"Procriar\u2014Centro de Procria\u00e7\u00e3o Medicamente Assistida, 4100-130 Porto, Portugal"}]},{"given":"Lu\u00eds F.","family":"Vicente","sequence":"additional","affiliation":[{"name":"Centro PMA Hospital Lus\u00edadas, 1500-458 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-665X","authenticated-orcid":false,"given":"Ana Cristina","family":"Ramalhinho","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"Assisted Reproduction Laboratory, Cova da Beira Local Health Unit, 6200-251 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-8998","authenticated-orcid":false,"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, University of Beira Interior, 6200-284 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The Immunopathophysiology of Endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol. 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