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Despite several studies regarding coffee responses to abiotic stresses, transcriptome modulation due to simultaneous stresses remains poorly understood. This study unravels transcriptomic responses under the combined action of drought and temperature in leaves from the two most traded species: Coffea canephora cv. Conilon Clone 153 (CL153) and C. arabica cv. Icatu. Substantial transcriptomic changes were found, especially in response to the combination of stresses that cannot be explained by an additive effect. A large number of genes were involved in stress responses, with photosynthesis and other physiologically related genes usually being negatively affected. In both genotypes, genes encoding for protective proteins, such as dehydrins and heat shock proteins, were positively regulated. Transcription factors (TFs), including MADS-box genes, were down-regulated, although responses were genotype-dependent. In contrast to Icatu, only a few drought- and heat-responsive DEGs were recorded in CL153, which also reacted more significantly in terms of the number of DEGs and enriched GO terms, suggesting a high ability to cope with stresses. This research provides novel insights into the molecular mechanisms underlying leaf Coffea responses to drought and heat, revealing their influence on gene expression.<\/jats:p>","DOI":"10.3390\/ijms25147995","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T11:40:36Z","timestamp":1721734836000},"page":"7995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptomic Analyses Reveal That Coffea arabica and Coffea canephora Have More Complex Responses under Combined Heat and Drought than under Individual Stressors"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-4831","authenticated-orcid":false,"given":"Isabel","family":"Marques","sequence":"first","affiliation":[{"name":"Plant-Environment Interactions and Biodiversity Lab, Forest Research Centre (CEF), Associate Laboratory TERRA, School of Agriculture (ISA), University of Lisbon, 1349-017 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-5942","authenticated-orcid":false,"given":"Isabel","family":"Fernandes","sequence":"additional","affiliation":[{"name":"cE3c\u2014Center for Ecology, Evolution and Environmental Changes and CHANGE\u2014Global Change and Sustainability Institute, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"given":"Oct\u00e1vio S.","family":"Paulo","sequence":"additional","affiliation":[{"name":"cE3c\u2014Center for Ecology, Evolution and Environmental Changes and CHANGE\u2014Global Change and Sustainability Institute, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]},{"given":"Dora","family":"Batista","sequence":"additional","affiliation":[{"name":"cE3c\u2014Center for Ecology, Evolution and Environmental Changes and CHANGE\u2014Global Change and Sustainability Institute, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"},{"name":"Linking Landscape, Environment, Agriculture and Food (LEAF), School of Agriculture (ISA), University of Lisbon, 1349-017 Lisboa, Portugal"}]},{"given":"Fernando C.","family":"Lidon","sequence":"additional","affiliation":[{"name":"Unidade de Geobioci\u00eancias, Geoengenharias e Geotecnologias (GeoBioTec), Faculdade de Ci\u00eancias e Tecnologia (FCT), Universidade NOVA de Lisboa (UNL), 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-6579","authenticated-orcid":false,"given":"Ana P.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Plant-Environment Interactions and Biodiversity Lab, Forest Research Centre (CEF), Associate Laboratory TERRA, School of Agriculture (ISA), University of Lisbon, 1349-017 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8830-0846","authenticated-orcid":false,"given":"F\u00e1bio L.","family":"Partelli","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio do Norte do Esp\u00edrito Santo (CEUNES), Departmento Ci\u00eancias Agr\u00e1rias e Biol\u00f3gicas (DCAB), Universidade Federal Esp\u00edrito Santo (UFES), S\u00e3o Mateus 29932-540, ES, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-8475","authenticated-orcid":false,"given":"F\u00e1bio M.","family":"DaMatta","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Vegetal, Universidade Federal Vi\u00e7osa (UFV), Vi\u00e7osa 36570-900, MG, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6071-6460","authenticated-orcid":false,"given":"Ana I.","family":"Ribeiro-Barros","sequence":"additional","affiliation":[{"name":"Plant-Environment Interactions and Biodiversity Lab, Forest Research Centre (CEF), Associate Laboratory TERRA, School of Agriculture (ISA), University of Lisbon, 1349-017 Lisboa, Portugal"},{"name":"Unidade de Geobioci\u00eancias, Geoengenharias e Geotecnologias (GeoBioTec), Faculdade de Ci\u00eancias e Tecnologia (FCT), Universidade NOVA de Lisboa (UNL), 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-7214","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Plant-Environment Interactions and Biodiversity Lab, Forest Research Centre (CEF), Associate Laboratory TERRA, School of Agriculture (ISA), University of Lisbon, 1349-017 Lisboa, Portugal"},{"name":"Unidade de Geobioci\u00eancias, Geoengenharias e Geotecnologias (GeoBioTec), Faculdade de Ci\u00eancias e Tecnologia (FCT), Universidade NOVA de Lisboa (UNL), 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"ref_1","unstructured":"Masson-Delmotte, V.P., Zhai, A., Pirani, S.L., Connors, C., P\u00e9an, S., Berger, N., Caud, Y., Chen, L., Goldfarb, M.I., and Gomis, M. 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