{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:30:19Z","timestamp":1769844619459,"version":"3.49.0"},"reference-count":5,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundo Europeu de Desenvolvimento Regional (FEDER) funds through the COMPETE 2020 Operational Programme for Competitiveness and Internationalisation (PO-CI), Portugal 2020","award":["IF\/00092\/2014\/CP1255\/CT0004"],"award-info":[{"award-number":["IF\/00092\/2014\/CP1255\/CT0004"]}]},{"name":"Portuguese funds through Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT) in the framework","award":["IF\/00092\/2014\/CP1255\/CT0004"],"award-info":[{"award-number":["IF\/00092\/2014\/CP1255\/CT0004"]}]},{"name":"CHAIR in Onco-Innovation from Faculty of Medicine, University of Porto (FMUP)","award":["IF\/00092\/2014\/CP1255\/CT0004"],"award-info":[{"award-number":["IF\/00092\/2014\/CP1255\/CT0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer is a significant global health problem with complex treatment challenges [...]<\/jats:p>","DOI":"10.3390\/ijms25189976","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:52:31Z","timestamp":1726624351000},"page":"9976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer Treatment: New Drugs and Strategies"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-1042","authenticated-orcid":false,"given":"Nuno","family":"Vale","sequence":"first","affiliation":[{"name":"PerMed Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Pl\u00e1cido da Costa, s\/n, 4200-450 Porto, Portugal"},{"name":"CINTESIS@RISE, Faculty of Medicine, University of Porto, Alameda Professor Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Rua Doutor Pl\u00e1cido da Costa, s\/n, 4200-450 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gambardella, V., Tarazona, N., Cejalvo, J.M., Lombardi, P., Huerta, M., Rosell\u00f3, S., Fleitas, T., Roda, D., and Cervantes, A. (2020). Personalized Medicine: Recent Progress in Cancer Therapy. Cancers, 12.","DOI":"10.3390\/cancers12041009"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-031-27156-4_10","article-title":"Targeted Therapy and Personalized Medicine","volume":"185","author":"Saeed","year":"2023","journal-title":"Cancer Treat Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2103836","DOI":"10.1002\/advs.202103836","article-title":"Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy","volume":"9","author":"Peng","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mendes, I., and Vale, N. (2023). How Can the Microbiome Induce Carcinogenesis and Modulate Drug Resistance in Cancer Therapy?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411855"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Costa, B., and Vale, N. (2023). Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914631"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/9976\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:57:28Z","timestamp":1760111848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/18\/9976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":5,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["ijms25189976"],"URL":"https:\/\/doi.org\/10.3390\/ijms25189976","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}