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Echinacea angustifolia DC. has traditionally been used for wound healing, burns, and other ailments. In this study, dried roots of E. angustifolia were extracted using a hydroalcoholic solution, and the phytochemical composition was analyzed through HPLC-DAD. The polyphenol and polysaccharide content, along with in vitro antioxidant and anti-tyrosinase properties, were evaluated. The biological effect of E. angustifolia extract was evaluated on the 3T3-L1 cell line. HPLC-DAD analysis confirmed the presence of several polyphenols, particularly caffeic acid derivatives, with echinacoside as the predominant compound, exhibiting strong antioxidant properties. The extract demonstrated no cytotoxic effect on 3T3-L1 cells, and it showed a protective effect by increasing the migration process in an in vitro scratch wound healing test, together with echinacoside and allantoin, which were used as references. Furthermore, the extract reduced the expression of proinflammatory cytokines and promoted that of proteins that accelerate wound closure, such as TGF-\u03b21. The present study demonstrates the potential wound healing properties and the antioxidant and anti-inflammatory activity of E. angustifolia root hydroalcoholic extract, giving a scientific rationale for its traditional use.<\/jats:p>","DOI":"10.3390\/ijms26062562","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:18:32Z","timestamp":1741839512000},"page":"2562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Composition and Wound Healing Properties of Echinacea angustifolia DC. Root Hydroalcoholic Extract"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-784X","authenticated-orcid":false,"given":"Daniela","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-7288","authenticated-orcid":false,"given":"Ludovica","family":"Lela","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"given":"Nadia","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-8633","authenticated-orcid":false,"given":"Immacolata","family":"Faraone","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"given":"Gianluca","family":"Paternoster","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-4396","authenticated-orcid":false,"given":"Patricia","family":"Valent\u00e3o","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Laborat\u00f3rio de Farmacognosia, Departamento de Qu\u00edmica, Faculdade de Farm\u00e1cia, Universidade do Porto, R. Jorge Viterbo Ferreira, n\u00b0 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-1237","authenticated-orcid":false,"given":"Luigi","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"given":"Monica","family":"Carmosino","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"ref_1","first-page":"385","article-title":"Wound healing potential of Spirulina platensis extracts on human dermal fibroblast cells","volume":"14","author":"Syarina","year":"2015","journal-title":"EXCLI J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/2211-5463.12241","article-title":"Tacorin, an extract from Ananas comosus stem, stimulates wound healing by modulating the expression of tumor necrosis factor (TNF)-\u03b1, transforming growth factor (TGF)-\u03b2 and matrix metalloproteinases 2 (MMPs2)","volume":"7","author":"Rahayu","year":"2017","journal-title":"FEBS Open Bio"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9480791","DOI":"10.1155\/2017\/9480791","article-title":"Determination of the Wound Healing Potentials of Medicinal Plants Historically Used in Ghana","volume":"2017","author":"Freiesleben","year":"2017","journal-title":"Evid. 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