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The current therapeutic approaches are limited in effectively regenerating damaged cardiac tissue. Up-to-date strategies for heart regeneration\/reconstitution aim at cardiac remodeling through repairing the damaged tissue with an external cell source or by stimulating the existing cells to proliferate and repopulate the compromised area. Cell reprogramming is addressed to this challenge as a promising solution, converting fibroblasts and other cell types into functional cardiomyocytes, either by reverting cells to a pluripotent state or by directly switching cell lineage. Several strategies such as gene editing and the application of miRNA and small molecules have been explored for their potential to enhance cardiac regeneration. Those strategies take advantage of cell plasticity by introducing reprogramming factors that regress cell maturity in vitro, allowing for their later differentiation and thus endorsing cell transplantation, or promote in situ cell proliferation, leveraged by scaffolds embedded with pro-regenerative factors promoting efficient heart restoration. Despite notable advancements, important challenges persist, including low reprogramming efficiency, cell maturation limitations, and safety concerns in clinical applications. Nonetheless, integrating these innovative approaches offers a promising alternative for restoring cardiac function and reducing the dependency on full heart transplants.<\/jats:p>","DOI":"10.3390\/ijms26073063","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:11:40Z","timestamp":1743135100000},"page":"3063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cell Reprogramming, Transdifferentiation, and Dedifferentiation Approaches for Heart Repair"],"prefix":"10.3390","volume":"26","author":[{"given":"Micael","family":"Almeida","sequence":"first","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-8335","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0295-1455","authenticated-orcid":false,"given":"Carlos M.","family":"Vital","sequence":"additional","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-4789","authenticated-orcid":false,"given":"Madalena R.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"given":"Beatriz C.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-0949","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Belo","sequence":"additional","affiliation":[{"name":"Stem Cells and Development Laboratory, iNOVA4Health, NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2024, April 03). Cardiovascular Diseases (CVDs). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-%28cvds%29."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.jacc.2007.09.011","article-title":"Universal Definition of Myocardial Infarction","volume":"50","author":"Thygesen","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrm3043","article-title":"Dedifferentiation, Transdifferentiation and Reprogramming: Three Routes to Regeneration","volume":"12","author":"Jopling","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for Cardiomyocyte Renewal in Humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/emmm.201201737","article-title":"Cardiomyocyte Proliferation and Progenitor Cell Recruitment Underlie Therapeutic Regeneration after Myocardial Infarction in the Adult Mouse Heart","volume":"5","author":"Malliaras","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Correia, C.D., Ferreira, A., Fernandes, M.T., Silva, B.M., Esteves, F., Leit\u00e3o, H.S., Bragan\u00e7a, J., and Calado, S.M. (2023). Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications\u2014Are We on the Road to Success?. Cells, 12.","DOI":"10.3390\/cells12131727"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ydbio.2019.04.006","article-title":"Insights into Regeneration Tool Box: An Animal Model Approach","volume":"453","author":"Mehta","year":"2019","journal-title":"Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wang, J., An, M., Haubner, B.J., and Penninger, J.M. (2023). Cardiac Regeneration: Options for Repairing the Injured Heart. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.981982"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Johnson, J., Mohsin, S., and Houser, S.R. (2021). Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157764"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.1038\/emm.2017.279","article-title":"Suppression of the Erk\u2013Srf Axis Facilitates Somatic Cell Reprogramming","volume":"50","author":"Huh","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kong, Y.P., Carrion, B., Singh, R.K., and Putnam, A.J. (2013). Matrix Identity and Tractional Forces Influence Indirect Cardiac Reprogramming. Sci. Rep., 3.","DOI":"10.1038\/srep03474"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCULATIONAHA.121.058655","article-title":"Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction","volume":"147","author":"Tani","year":"2023","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/org.1.2.1409","article-title":"Transdifferentiation, Metaplasia and Tissue Regeneration","volume":"1","author":"Shen","year":"2004","journal-title":"Organogenesis"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhao, M.T., Ye, S., Su, J., and Garg, V. (2020). Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.594226"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/CIRCULATIONAHA.118.033648","article-title":"Neonatal Heart Regeneration Comprehensive Literature Review","volume":"138","author":"Lam","year":"2018","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/CIRCULATIONAHA.121.054846","article-title":"Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity","volume":"144","author":"Payumo","year":"2021","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chingale, M., Zhu, D., Cheng, K., and Huang, K. (2021). Bioengineering Technologies for Cardiac Regenerative Medicine. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.681705"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/euhj.2001.2963","article-title":"Dissociation of Cardiomyocyte Apoptosis and Dedifferentiation in Infarct Border Zones","volume":"23","author":"Dispersyn","year":"2002","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1007\/s00018-021-03831-9","article-title":"Cardiac Regenerative Capacity: An Evolutionary Afterthought?","volume":"78","author":"Nguyen","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0167-5273(97)00117-4","article-title":"Abnormalities of Cardiocytes in Regions Bordering Fibrous Scars of Dogs with Heart Failure","volume":"60","author":"Sharov","year":"1997","journal-title":"Int. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11237","DOI":"10.1073\/pnas.1605431113","article-title":"Fast Revascularization of the Injured Area Is Essential to Support Zebrafish Heart Regeneration","volume":"113","author":"Marass","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e25605","DOI":"10.7554\/eLife.25605","article-title":"Reciprocal Analyses in Zebrafish and Medaka Reveal That Harnessing the Immune Response Promotes Cardiac Regeneration","volume":"6","author":"Lai","year":"2017","journal-title":"eLife"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/FJC.0000000000000003","article-title":"The Immune System and the Remodeling Infarcted Heart: Cell Biological Insights and Therapeutic Opportunities","volume":"63","author":"Frangogiannis","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Venugopal, H., Hanna, A., Humeres, C., and Frangogiannis, N.G. (2022). Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction. Cells, 11.","DOI":"10.3390\/cells11091386"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Shults, N.V., Suzuki, Y.J., Shults, N.V., and Suzuki, Y.J. (2021). Evidence for the Role of Cell Reprogramming in Naturally Occurring Cardiac Repair. Muscle Cell and Tissue\u2014Novel Molecular Targets and Current Advances, IntechOpen.","DOI":"10.1101\/2020.10.16.342493"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00011-017-1060-4","article-title":"Role of the Immune System in Cardiac Tissue Damage and Repair Following Myocardial Infarction","volume":"66","author":"Saparov","year":"2017","journal-title":"Inflamm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41569-018-0046-4","article-title":"The Epicardium as a Hub for Heart Regeneration","volume":"15","author":"Cao","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12015-019-09935-x","article-title":"Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications","volume":"16","author":"Liu","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"107925","DOI":"10.1016\/j.celrep.2020.107925","article-title":"Metabolic Maturation Media Improve Physiological Function of Human IPSC-Derived Cardiomyocytes","volume":"32","author":"Feyen","year":"2020","journal-title":"Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Correia, C., Koshkin, A., Duarte, P., Hu, D., Teixeira, A., Domian, I., Serra, M., and Alves, P.M. (2017). Distinct Carbon Sources Affect Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-08713-4"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5045\/br.2014.49.1.7","article-title":"Disease Modeling and Cell Based Therapy with IPSC: Future Therapeutic Option with Fast and Safe Application","volume":"49","author":"Kim","year":"2014","journal-title":"Blood Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Attar, A., Hosseinpour, A., Hosseinpour, H., and Kazemi, A. (2022). Major Cardiovascular Events after Bone Marrow Mononuclear Cell Transplantation Following Acute Myocardial Infarction: An Updated Post-BAMI Meta-Analysis of Randomized Controlled Trials. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02701-x"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.stem.2008.03.010","article-title":"Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors","volume":"2","author":"Wang","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The Bone Marrow Niche for Haematopoietic Stem Cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jsps.2022.06.017","article-title":"Opportunities and Challenges in Stem Cell Therapy in Cardiovascular Diseases: Position Standing in 2022","volume":"30","author":"Mahmud","year":"2022","journal-title":"Saudi Pharm. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/01.RES.0000235986.35957.a3","article-title":"Essential Role of ICAM-1\/CD18 in Mediating EPC Recruitment, Angiogenesis, and Repair to the Infarcted Myocardium","volume":"99","author":"Wu","year":"2006","journal-title":"Circ. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s13287-021-02443-1","article-title":"Surfing the Clinical Trials of Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy","volume":"12","author":"Matta","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1634\/stemcells.2005-0386","article-title":"The Role of the Sca-1\/CD31 Cardiac Progenitor Cell Population in Postinfarction Left Ventricular Remodeling","volume":"24","author":"Wang","year":"2006","journal-title":"Stem Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"640","DOI":"10.14202\/vetworld.2017.640-649","article-title":"Induced Pluripotent Stem Cell: A Headway in Reprogramming with Promising Approach in Regenerative Biology","volume":"10","author":"Rawat","year":"2017","journal-title":"Vet. World"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.semcdb.2021.07.010","article-title":"Direct Cardiac Reprogramming Comes of Age: Recent Advance and Remaining Challenges","volume":"122","author":"Xie","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.stem.2016.02.001","article-title":"Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts","volume":"18","author":"Zhang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(86)90507-6","article-title":"Transfection of a DNA Locus That Mediates the Conversion of LOTV2 Fibroblasts to Myoblasts","volume":"47","author":"Lassar","year":"1986","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(87)90585-X","article-title":"Expression of a Single Transfected CDNA Converts Fibmblasts to Myoblasts","volume":"51","author":"Davis","year":"1987","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cr.2018.01.001","article-title":"Cardiac Progenitor Reprogramming for Heart Regeneration","volume":"7","author":"Ebrahimi","year":"2018","journal-title":"Cell Regen."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/CIRCULATIONAHA.105.590653","article-title":"Stem Cell Therapy for Cardiac Repair: Ready for the next Step","volume":"114","author":"Boyle","year":"2006","journal-title":"Circulation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1016\/j.cell.2023.10.030","article-title":"Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects","volume":"186","author":"Schmidt","year":"2023","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Christoffels, V., and Jensen, B. (2020). Cardiac Morphogenesis: Specification of the Four-Chambered Heart. Cold Spring Harb. Perspect. Biol., 12.","DOI":"10.1101\/cshperspect.a037143"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bruneau, B.G. (2013). Signaling and Transcriptional Networks in Heart Development and Regeneration. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a008292"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.stemcr.2021.09.010","article-title":"Retinoic Acid Signaling in Heart Development: Application in the Differentiation of Cardiovascular Lineages from Human Pluripotent Stem Cells","volume":"16","author":"Wiesinger","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"In\u00e1cio, J.M., Nunes, M.M., Almeida, M., Cristo, F., Anjos, R., and Belo, J.A. (2023). Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation. Cells, 12.","DOI":"10.3390\/cells12040520"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"He, X., Liang, J., Paul, C., Huang, W., Dutta, S., and Wang, Y. (2022). Advances in Cellular Reprogramming-Based Approaches for Heart Regenerative Repair. Cells, 11.","DOI":"10.3390\/cells11233914"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sharma, A., Zhang, Y., Buikema, J.W., Serpooshan, V., Chirikian, O., Kosaric, N., Churko, J.M., Dzilic, E., Shieh, A., and Burridge, P.W. (2018). Stage-Specific Effects of Bioactive Lipids on Human IPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-24954-3"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cristo, F., In\u00e1cio, J.M., de Almeida, S., Mendes, P., Martins, D.S., Maio, J., Anjos, R., and Belo, J.A. (2017). Functional Study of DAND5 Variant in Patients with Congenital Heart Disease and Laterality Defects. BMC Med. Genet., 18.","DOI":"10.1186\/s12881-017-0444-1"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.addr.2015.04.019","article-title":"Maturing Human Pluripotent Stem Cell-Derived Cardiomyocytes in Human Engineered Cardiac Tissues","volume":"96","author":"Feric","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Scesa, G., Adami, R., and Bottai, D. (2021). IPSC Preparation and Epigenetic Memory: Does the Tissue Origin Matter?. Cells, 10.","DOI":"10.3390\/cells10061470"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/stmcls\/sxac020","article-title":"Human Induced Pluripotent Stem Cells: From Cell Origin, Genomic Stability, and Epigenetic Memory to Translational Medicine","volume":"40","author":"Poetsch","year":"2022","journal-title":"Stem Cells"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"A30","DOI":"10.5114\/wo.2014.47135","article-title":"Epigenetic Mechanisms of Induced Pluripotency","volume":"1A","author":"Andrzejewska","year":"2015","journal-title":"Wspolczesna Onkol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2217\/epi-2016-0032","article-title":"Transcriptional and Epigenetic Mechanisms of Cellular Reprogramming to Induced Pluripotency","volume":"8","author":"Kenis","year":"2016","journal-title":"Epigenomics"},{"key":"ref_61","first-page":"iv67","article-title":"Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Cardiac Progenitor Cells: Effects of Selective Ion Channel Blockade","volume":"18","author":"Altomare","year":"2016","journal-title":"Europace"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Pianezzi, E., Altomare, C., Bolis, S., Balbi, C., Torre, T., Rinaldi, A., Camici, G.G., Barile, L., and Vassalli, G. (2020). Role of Somatic Cell Sources in the Maturation Degree of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Biochim. Biophys. Acta Mol. Cell Res., 1867.","DOI":"10.1016\/j.bbamcr.2019.118538"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"G\u00e4hwiler, E.K.N., Motta, S.E., Martin, M., Nugraha, B., Hoerstrup, S.P., and Emmert, M.Y. (2021). Human IPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.639699"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2050-490X-1-6","article-title":"Current Status of Induced Pluripotent Stem Cells in Cardiac Tissue Regeneration and Engineering","volume":"1","author":"Liu","year":"2013","journal-title":"Regen. Med. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Grath, A., and Dai, G. (2019). Direct Cell Reprogramming for Tissue Engineering and Regenerative Medicine. J. Biol. Eng., 13.","DOI":"10.1186\/s13036-019-0144-9"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/01.CIR.0000085658.98621.49","article-title":"Ventricular Remodeling after Infarction and the Extracellular Collagen Matrix: When Is Enough Enough?","volume":"108","author":"Jugdutt","year":"2003","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2302\/kjm.2019-0008-OA","article-title":"Direct Cardiac Reprogramming for Cardiovascular Regeneration and Differentiation","volume":"69","author":"Sadahiro","year":"2020","journal-title":"Keio J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ifkovits, J.L., Addis, R.C., Epstein, J.A., and Gearhart, J.D. (2014). Inhibition of TGF\u03b2 Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089678"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1038\/ncomms9243","article-title":"High-Efficiency Reprogramming of Fibroblasts into Cardiomyocytes Requires Suppression of Pro-Fibrotic Signalling","volume":"6","author":"Zhao","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm2654","article-title":"\u03b2-Catenin Hits Chromatin: Regulation of Wnt Target Gene Activation","volume":"10","author":"Mosimann","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.5966\/sctm.2015-0136","article-title":"Generation of Functional Human Cardiac Progenitor Cells by High-Efficiency Protein Transduction","volume":"4","author":"Li","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCRESAHA.116.305547","article-title":"Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming","volume":"116","author":"Wang","year":"2015","journal-title":"Circ. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.116.304510","article-title":"MicroRNA Induced Cardiac Reprogramming in Vivo Evidence for Mature Cardiac Myocytes and Improved Cardiac Function","volume":"116","author":"Jayawardena","year":"2014","journal-title":"Circ. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/CIRCRESAHA.112.269035","article-title":"Cellular Biology MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes","volume":"110","author":"Jayawardena","year":"2012","journal-title":"Circ. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41580-021-00335-z","article-title":"Direct Cell Reprogramming: Approaches, Mechanisms and Progress","volume":"22","author":"Wang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Muneta, L., Miranda-Arrubla, J., and Carvajal-Vergara, X. (2020). The Future of Direct Cardiac Reprogramming: Any Gmt Cocktail Variety?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217950"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Srivastava, D. (2016). Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology, Springer.","DOI":"10.1007\/978-4-431-54628-3_1"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature24454","article-title":"Single-Cell Transcriptomics Reconstructs Fate Conversion from Fibroblast to Cardiomyocyte","volume":"551","author":"Liu","year":"2017","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.stem.2015.12.001","article-title":"Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors","volume":"18","author":"Lalit","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart Repair by Reprogramming Non-Myocytes with Cardiac Transcription Factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Christoforou, N., Chellappan, M., Adler, A.F., Kirkton, R.D., Wu, T., Addis, R.C., Bursac, N., and Leong, K.W. (2013). Transcription Factors MYOCD, SRF, Mesp1 and SMARCD3 Enhance the Cardio-Inducing Effect of GATA4, TBX5, and MEF2C during Direct Cellular Reprogramming. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063577"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11936-015-0404-z","article-title":"Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine","volume":"17","author":"Sharma","year":"2015","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Zhao, H., Zhang, Y., Xu, X., Sun, Q., Yang, C., Wang, H., Yang, J., Yang, Y., Yang, X., and Liu, Y. (2021). Sall4 and Myocd Empower Direct Cardiac Reprogramming from Adult Cardiac Fibroblasts After Injury. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.608367"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41419-018-0891-4","article-title":"Transdifferentiation: A New Promise for Neurodegenerative Diseases","volume":"9","author":"Mollinari","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.15252\/emmm.201504395","article-title":"Reprogramming and Transdifferentiation for Cardiovascular Development and Regenerative Medicine: Where Do We Stand?","volume":"7","author":"Ebert","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ydbio.2003.12.034","article-title":"Differences between Human and Mouse Embryonic Stem Cells","volume":"269","author":"Ginis","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Christoforou, N., Chakraborty, S., Kirkton, R.D., Adler, A.F., Addis, R.C., and Leong, K.W. (2017). Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards the Cardiac Cell Lineage. Sci. Rep., 7.","DOI":"10.1038\/srep40285"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.stemcr.2013.07.005","article-title":"Direct Reprogramming of Human Fibroblasts Toward a Cardiomyocyte-Like State","volume":"1","author":"Fu","year":"2013","journal-title":"Stem Cell Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"12667","DOI":"10.1073\/pnas.1304053110","article-title":"Induction of Human Cardiomyocyte-Like Cells from Fibroblasts by Defined Factors","volume":"110","author":"Wada","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/cr.2015.99","article-title":"Direct Reprogramming of Mouse Fibroblasts into Cardiomyocytes with Chemical Cocktails","volume":"25","author":"Fu","year":"2015","journal-title":"Cell Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"147598","DOI":"10.1016\/j.gene.2023.147598","article-title":"Positive Effect of MiR-2392 on Fibroblast to Cardiomyocyte-like Cell Fate Transition: An In Silico and In Vitro Study","volume":"879","author":"Aalikhani","year":"2023","journal-title":"Gene"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stem.2019.05.020","article-title":"Single-Cell Transcriptomic Analyses of Cell Fate Transitions During Human Cardiac Reprogramming","volume":"25","author":"Zhou","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"100010","DOI":"10.1016\/j.xpro.2019.100010","article-title":"An Optimized Protocol for Human Direct Cardiac Reprogramming","volume":"1","author":"Garbutt","year":"2020","journal-title":"Star Protoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1073\/pnas.1301019110","article-title":"Reprogramming of Human Fibroblasts toward a Cardiac Fate","volume":"110","author":"Nam","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ymthe.2021.10.015","article-title":"CRISPR Activation of Endogenous Genes Reprograms Fibroblasts into Cardiovascular Progenitor Cells for Myocardial Infarction Therapy","volume":"30","author":"Jiang","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.apsb.2019.09.003","article-title":"Lineage Reprogramming of Fibroblasts into Induced Cardiac Progenitor Cells by CRISPR\/Cas9-Based Transcriptional Activators","volume":"10","author":"Wang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2012.09.045","article-title":"Facilitators and Impediments of the Pluripotency Reprogramming Factors\u2019 Initial Engagement with the Genome","volume":"151","author":"Soufi","year":"2012","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.stem.2016.02.003","article-title":"Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming","volume":"18","author":"Zhou","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.biomaterials.2015.07.063","article-title":"Enhanced Efficiency of Genetic Programming toward Cardiomyocyte Creation through Topographical Cues","volume":"70","author":"Morez","year":"2015","journal-title":"Biomaterials"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Bektik, E., Sun, Y., Dennis, A.T., Sakon, P., Yang, D., Desch\u00eanes, I., and Fu, J.D. (2021). Inhibition of Creb-Cbp Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming. Cells, 10.","DOI":"10.20944\/preprints202104.0565.v1"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Bektik, E., and Fu, J.D. (2019). Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming. Cells, 8.","DOI":"10.3390\/cells8070679"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Li, X., Xing, J., Zhou, J., and Li, H. (2023). Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112913"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/gt.2009.151","article-title":"Zinc Positive: Tailored Genome Engineering Meets Reprogramming","volume":"17","author":"Cathomen","year":"2010","journal-title":"Gene Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1126\/science.aaf1502","article-title":"Conversion of human Fibroblasts into Functional Cardiomyocytes by Small Molecules","volume":"352","author":"Cao","year":"2016","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1007\/s00018-017-2586-x","article-title":"Small Molecules for Reprogramming and Transdifferentiation","volume":"74","author":"Qin","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Shafi, O., Zahra, K., and Shah, H.H. (2024). Dysregulations in Cardiogenic Mechanisms by TGF-Beta and Angiotensin II in Cardiac Remodeling Post-Ischemic Injury: A Systematic Review. medRxiv.","DOI":"10.1101\/2024.07.11.24310260"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1074\/jbc.M114.609016","article-title":"Inhibition of Transforming Growth Factor \u03b2 (TGF-\u03b2) Signaling Can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency","volume":"290","author":"Tan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/07391102.2017.1289124","article-title":"Structural and Mechanistic Insights into Nuclear Transport and Delivery of the Critical Pluripotency Factor Oct4 to DNA","volume":"36","author":"Okuyama","year":"2018","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.cellsig.2014.06.002","article-title":"Mechanism of SB431542 in Inhibiting Mouse Embryonic Stem Cell Differentiation","volume":"26","author":"Du","year":"2014","journal-title":"Cell Signal"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.stem.2010.11.015","article-title":"Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds","volume":"7","author":"Zhu","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.stem.2009.09.012","article-title":"A Small-Molecule Inhibitor of Tgf-\u03b2 Signaling Replaces Sox2 in Reprogramming by Inducing Nanog","volume":"5","author":"Ichida","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/cb100323z","article-title":"Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt\/\u03b2-Catenin Signaling","volume":"6","author":"Wang","year":"2011","journal-title":"Acs Chem. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1074\/jbc.RA119.012231","article-title":"The Evolutionarily Conserved MAPK\/Erk Signaling Promotes Ancestral T-Cell Immunity in Fish via c-Myc-Mediated Glycolysis","volume":"295","author":"Wei","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","article-title":"The Selectivity of Protein Kinase Inhibitors: A Further Update","volume":"408","author":"Bain","year":"2007","journal-title":"Biochem. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1016\/j.bmcl.2008.10.054","article-title":"The Discovery of the Benzhydroxamate MEK Inhibitors CI-1040 and PD 0325901","volume":"18","author":"Barrett","year":"2008","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"17266","DOI":"10.1073\/pnas.0608156103","article-title":"Self-Renewal of Embryonic Stem Cells by a Small Molecule","volume":"103","author":"Chen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1073\/pnas.1516237112","article-title":"Akt1\/Protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes","volume":"112","author":"Zhou","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.stemcr.2015.10.019","article-title":"Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming Under Defined Conditions","volume":"5","author":"Yamakawa","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.stemcr.2017.01.025","article-title":"Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity","volume":"8","author":"Abad","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kanda, M., Nagai, T., Takahashi, T., Liu, M.L., Kondou, N., Naito, A.T., Akazawa, H., Sashida, G., Iwama, A., and Komuro, I. (2016). Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156562"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/sctm.19-0069","article-title":"Discovery of Retinoic Acid Receptor Agonists as Proliferators of Cardiac Progenitor Cells through a Phenotypic Screening Approach","volume":"9","author":"Drowley","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF00189066","article-title":"In Vitro Differentiation of Embryonic Stem Cells into Cardiomyocytes or Skeletal Muscle Cells Is Specifically Modulated by Retinoic Acid","volume":"204","author":"Wobus","year":"1994","journal-title":"Roux\u2019s Arch. Dev. Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3892\/ijmm.2014.1623","article-title":"Expression of Retinoic Acid Target Genes in Coronary Artery Disease","volume":"33","author":"Bilbija","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/s41467-023-36764-x","article-title":"Retinoic Acid Signaling Modulation Guides In Vitro Specification of Human Heart Field-Specific Progenitor Pools","volume":"14","author":"Zawada","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41422-018-0036-4","article-title":"Chemical-Induced Cardiac Reprogramming In Vivo","volume":"28","author":"Huang","year":"2018","journal-title":"Cell Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molcel.2007.01.017","article-title":"Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase","volume":"25","author":"Kubicek","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41368-019-0053-2","article-title":"Harnessing the HDAC\u2013Histone Deacetylase Enzymes, Inhibitors and How These Can Be Utilised in Tissue Engineering","volume":"11","author":"Lawlor","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1002\/stem.240","article-title":"Generation of Human-Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2","volume":"27","author":"Li","year":"2009","journal-title":"Stem Cells"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.stem.2017.11.010","article-title":"Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction","volume":"22","author":"Miyamoto","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e000119","DOI":"10.1161\/JAHA.113.000119","article-title":"Gene Therapy to Treat Cardiovascular Disease","volume":"2","author":"Wolfram","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/hum.2011.042","article-title":"Transendocardial Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus Macaques","volume":"22","author":"Gao","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1038\/mt.2008.202","article-title":"Percutaneous Transendocardial Delivery of Self-Complementary Adeno-Associated Virus 6 Achieves Global Cardiac Gene Transfer in Canines","volume":"16","author":"Bish","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ymthe.2006.03.014","article-title":"Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior to That of AAV8","volume":"14","author":"Inagaki","year":"2006","journal-title":"Mol. Ther."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1021\/acsomega.8b00904","article-title":"Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease","volume":"3","author":"Yoo","year":"2018","journal-title":"Acs Omega"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/HCO.0000000000000386","article-title":"Cardiac Gene Therapy with Adeno-Associated Virus-Based Vectors","volume":"32","author":"Chamberlain","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"609","DOI":"10.18609\/cgti.2020.073","article-title":"Consideration of Clinical Translation of Cardiac AAV Gene Therapy","volume":"6","author":"Yamada","year":"2020","journal-title":"Cell Gene Ther. Insights"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2147\/IJN.S304873","article-title":"Highly Efficient MicroRNA Delivery Using Functionalized Carbon Dots for Enhanced Conversion of Fibroblasts to Cardiomyocytes","volume":"16","author":"Yang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"eabj6621","DOI":"10.1126\/sciadv.abj6621","article-title":"Ultraefficient Extracellular Vesicle-Guided Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes","volume":"8","author":"Kim","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biomaterials.2018.11.034","article-title":"Efficient In Vivo Direct Conversion of Fibroblasts into Cardiomyocytes Using a Nanoparticle-Based Gene Carrier","volume":"192","author":"Chang","year":"2019","journal-title":"Biomaterials"},{"key":"ref_141","first-page":"1","article-title":"In Vivo Imaging of Transduction Efficiencies of Cardiac Targeting Peptide","volume":"2020","author":"Feldman","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Wang, Q., Song, Y., Chen, J., Li, Q., Gao, J., Tan, H., Zhu, Y., Wang, Z., Li, M., and Yang, H. (2021). Direct In Vivo Reprogramming with Non-Viral Sequential Targeting Nanoparticles Promotes Cardiac Regeneration. Biomaterials, 276.","DOI":"10.1016\/j.biomaterials.2021.121028"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"19551","DOI":"10.1021\/acsnano.2c10043","article-title":"Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen-Releasing Nanoparticles After or Even Before Acute Myocardial Infarction","volume":"16","author":"Guan","year":"2022","journal-title":"Acs Nano"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1021\/nl2025882","article-title":"Nanoparticles Targeting the Infarcted Heart","volume":"11","author":"Dvir","year":"2011","journal-title":"Nano Lett."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Omidian, H., Babanejad, N., and Cubeddu, L.X. (2023). Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071935"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Saludas, L., Oliveira, C.C., Roncal, C., Ruiz-Villalba, A., Pr\u00f3sper, F., Garbayo, E., and Blanco-Prieto, M.J. (2021). Extracellular Vesicle-Based Therapeutics for Heart Repair. Nanomaterials, 11.","DOI":"10.3390\/nano11030570"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.yjmcc.2024.04.002","article-title":"C166 EVs Potentiate MiR Cardiac Reprogramming via MiR-148a-3p","volume":"190","author":"Sun","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCRESAHA.120.316958","article-title":"Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation","volume":"127","author":"Gibb","year":"2020","journal-title":"Circ. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"269","DOI":"10.18585\/inabj.v14i3.1888","article-title":"MicroRNA-1 Induces Transdifferentiation of Peripheral Blood CD34+ Cells into Cardiomyocytes-Like Cells","volume":"14","author":"Pikir","year":"2022","journal-title":"Indones. Biomed. J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1021\/nn5020787","article-title":"Injectable Graphene Oxide\/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair","volume":"8","author":"Paul","year":"2014","journal-title":"Acs Nano"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41536-020-00099-8","article-title":"Dedifferentiation: Inspiration for Devising Engineering Strategies for Regenerative Medicine","volume":"5","author":"Yao","year":"2020","journal-title":"NPJ Regen. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of Neonatal and Adult Mammalian Heart Regeneration by the MiR-15 Family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41421-019-0095-9","article-title":"Single-Cell Imaging and Transcriptomic Analyses of Endogenous Cardiomyocyte Dedifferentiation and Cycling","volume":"5","author":"Zhang","year":"2019","journal-title":"Cell Discov."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1039\/C9BM01003C","article-title":"Cardiomyocyte Dedifferentiation and Remodeling in 3D Scaffolds to Generate the Cellular Diversity of Engineering Cardiac Tissues","volume":"7","author":"Wang","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1749-6632.2009.05100.x","article-title":"Return to the Fetal Gene Program: A Suggested Metabolic Link to Gene Expression in the Heart","volume":"Volume 1188","author":"Taegtmeyer","year":"2010","journal-title":"Proceedings of the Annals of the New York Academy of Sciences"},{"key":"ref_156","first-page":"18","article-title":"Regeneration of the Heart: From Molecular Mechanisms to Clinical Therapeutics","volume":"10","author":"Guo","year":"2023","journal-title":"Mil. Med. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/abbs\/gmv137","article-title":"Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf\/Mek\/Erk signaling pathway","volume":"48","author":"Zhang","year":"2016","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/CIRCRESAHA.118.314048","article-title":"Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload","volume":"124","author":"Ikeda","year":"2019","journal-title":"Circ. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4161\/cc.11.3.19024","article-title":"The Janus Face of OSM-Mediated Cardiomyocyte Dedifferentiation during Cardiac Repair and Disease","volume":"11","author":"Gajawada","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M Is a Major Mediator of Cardiomyocyte Dedifferentiation and Remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.136.1.155","article-title":"Newt Myotubes Reenter the Cell Cycle by Phosphorylation of the Retinoblastoma Protein","volume":"136","author":"Tanaka","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"eabi6648","DOI":"10.1126\/sciadv.abi6648","article-title":"Repression of Osmr and Fgfr1 by MiR-1\/133a Prevents Cardiomyocyte Dedifferentiation and Cell Cycle Entry in the Adult Heart","volume":"7","author":"Valussi","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1242\/dev.126649","article-title":"Dynamic Microrna-101a and Fosab Expression Controls Zebrafish Heart Regeneration","volume":"142","author":"Beauchemin","year":"2015","journal-title":"Development"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ydbio.2012.02.018","article-title":"Regulation of Zebrafish Heart Regeneration by MiR-133","volume":"365","author":"Yin","year":"2012","journal-title":"Dev. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","article-title":"Hippo Signaling Impedes Adult Heart Regeneration","volume":"140","author":"Heallen","year":"2013","journal-title":"Development"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/cvr\/cvy243","article-title":"Yap Is Required for Scar Formation but Not Myocyte Proliferation During Heart Regeneration in Zebrafish","volume":"115","author":"Flinn","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Neininger, A.C., Long, J.H., Baillargeon, S.M., and Burnette, D.T. (2019). A Simple and Flexible High-Throughput Method for the Study of Cardiomyocyte Proliferation. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-52467-0"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the Nuclear Target of Hippo Signaling, Stimulates Heart Growth Through Cardiomyocyte Proliferation but Not Hypertrophy","volume":"109","author":"Lin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.cophys.2022.100492","article-title":"Hippo-Yap Signaling in Cardiac and Fibrotic Remodeling","volume":"26","year":"2022","journal-title":"Curr. Opin. Physiol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Liu, R., Jagannathan, R., Li, F., Lee, J., Balasubramanyam, N., Kim, B.S., Yang, P., Yechoor, V.K., and Moulik, M. (2019). Tead1 Is Required for Perinatal Cardiomyocyte Proliferation. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212017"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41418-017-0036-9","article-title":"TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated MiR-152 Expression","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Lozano-Velasco, E., In\u00e1cio, J.M., Sousa, I., Guimar\u00e3es, A.R., Franco, D., Moura, G., and Belo, J.A. (2024). MiRNAs in Heart Development and Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031673"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","article-title":"Functional Screening Identifies MiRNAs Inducing Cardiac Regeneration","volume":"492","author":"Eulalio","year":"2012","journal-title":"Nature"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCRESAHA.112.300658","article-title":"Mir-17-92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts","volume":"112","author":"Chen","year":"2013","journal-title":"Circ. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.116.309589","article-title":"Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction","volume":"120","author":"Lesizza","year":"2017","journal-title":"Circ. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","article-title":"A MicroRNA-Hippo Pathway That Promotes Cardiomyocyte Proliferation and Cardiac Regeneration in Mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.celrep.2019.05.005","article-title":"Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation","volume":"27","author":"Torrini","year":"2019","journal-title":"Cell Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","article-title":"MicroRNA Therapy Stimulates Uncontrolled Cardiac Repair After Myocardial Infarction in Pigs","volume":"569","author":"Gabisonia","year":"2019","journal-title":"Nature"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s13287-018-1086-8","article-title":"Wnt\/\u03b2-Catenin-Mediated Signaling Re-Activates Proliferation of Matured Cardiomyocytes","volume":"9","author":"Fan","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.1311705111","article-title":"Notch Signaling Regulates Cardiomyocyte Proliferation during Zebrafish Heart Regeneration","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/CIRCRESAHA.113.301075","article-title":"C3orf58, a Novel Paracrine Protein, Stimulates Cardiomyocyte Cell-Cycle Progression through the PI3K-AKT-CDK7 Pathway","volume":"113","author":"Beigi","year":"2013","journal-title":"Circ. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.celrep.2019.06.065","article-title":"PDGFR-\u03b2 Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration","volume":"28","author":"Yue","year":"2019","journal-title":"Cell Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e05871","DOI":"10.7554\/eLife.05871","article-title":"Nrg1 Is an Injury-Induced Cardiomyocyte Mitogen for the Endogenous Heart Regeneration Program in Zebrafish","volume":"4","author":"Gemberling","year":"2015","journal-title":"eLife"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury","volume":"138","author":"Bersell","year":"2009","journal-title":"Cell"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"11889","DOI":"10.1073\/pnas.1834204100","article-title":"Activation of Notch Signaling Pathway Precedes Heart Regeneration in Zebrafish\u00b4Angel","volume":"100","author":"Raya","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1038\/s41467-021-25653-w","article-title":"Nrf1 Promotes Heart Regeneration and Repair by Regulating Proteostasis and Redox Balance","volume":"12","author":"Cui","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/CIRCRESAHA.116.310051","article-title":"Mammalian Heart Regeneration","volume":"120","author":"Doppler","year":"2017","journal-title":"Circ. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 Triggers Mammalian Heart Regeneration by Promoting Cardiomyocyte Dedifferentiation and Proliferation","volume":"17","author":"Aharonov","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.celrep.2018.12.048","article-title":"Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism","volume":"26","author":"Zhao","year":"2019","journal-title":"Cell Rep."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"13255","DOI":"10.1073\/pnas.1511209112","article-title":"Myocardial NF-\u039aB Activation Is Essential for Zebrafish Heart Regeneration","volume":"112","author":"Karra","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.12.010","article-title":"Spatially Resolved Genome-Wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration","volume":"36","author":"Wu","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11886-021-01459-6","article-title":"A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals","volume":"23","author":"Brezitski","year":"2021","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle","volume":"23","author":"Gupta","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","article-title":"Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration","volume":"173","author":"Mohamed","year":"2018","journal-title":"Cell"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"18033","DOI":"10.1074\/jbc.M113.541953","article-title":"Repression of Cyclin D1 Expression Is Necessary for the Maintenance of Cell Cycle Exit in Adult Mammalian Cardiomyocytes","volume":"289","author":"Tane","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000152326.91223.4F","article-title":"Targeted Expression of Cyclin D2 Results in Cardiomyocyte DNA Synthesis and Infarct Regression in Transgenic Mice","volume":"96","author":"Pasumarthi","year":"2005","journal-title":"Circ. Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1161\/CIRCRESAHA.107.153544","article-title":"Cyclin A2 Induces Cardiac Regeneration after Myocardial Infarction and Prevents Heart Failure","volume":"100","author":"Cheng","year":"2007","journal-title":"Circ. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1161\/CIRCULATIONAHA.118.038361","article-title":"Loss of Super-Enhancer-Regulated CircRNA Nfix Induces Cardiac Regeneration after Myocardial Infarction in Adult Mice","volume":"139","author":"Huang","year":"2019","journal-title":"Circulation"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41467-018-03019-z","article-title":"Loss of MicroRNA-128 Promotes Cardiomyocyte Proliferation and Heart Regeneration","volume":"9","author":"Huang","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.devcel.2015.04.021","article-title":"HIF1\u03b1 Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes","volume":"33","author":"Stowe","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature14582","article-title":"Hypoxia Fate Mapping Identifies Cycling Cardiomyocytes in the Adult Heart","volume":"523","author":"Kimura","year":"2015","journal-title":"Nature"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0140-6736(08)61237-4","article-title":"Acute Myocardial Infarction","volume":"372","author":"White","year":"2008","journal-title":"Lancet"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2459\/JCM.0000000000001233","article-title":"Marginal Donors and Organ Shortness: Concomitant Surgical Procedures During Heart Transplantation: A Literature Review","volume":"23","author":"Piperata","year":"2022","journal-title":"J. Cardiovasc. Med."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Liu, C., Han, D., Liang, P., Li, Y., and Cao, F. (2021). The Current Dilemma and Breakthrough of Stem Cell Therapy in Ischemic Heart Disease. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.636136"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Masumoto, H., Nakane, T., Tinney, J.P., Yuan, F., Ye, F., Kowalski, W.J., Minakata, K., Sakata, R., Yamashita, J.K., and Keller, B.B. (2016). The Myocardial Regenerative Potential of Three-Dimensional Engineered Cardiac Tissues Composed of Multiple Human IPS Cell-Derived Cardiovascular Cell Lineages. Sci. Rep., 6.","DOI":"10.1038\/srep29933"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"eaat9365","DOI":"10.1126\/sciadv.aat9365","article-title":"Cardiac Cell-Integrated Microneedle Patch for Treating Myocardial Infarction","volume":"4","author":"Tang","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/sctm.18-0134","article-title":"Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells\u2014Ready for Take-Off","volume":"8","author":"Haake","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.stemcr.2016.05.001","article-title":"Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines","volume":"6","author":"Daley","year":"2016","journal-title":"Stem Cell Rep."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrg2937","article-title":"Methods for Making Induced Pluripotent Stem Cells: Reprogramming \u00e0 La Carte","volume":"12","author":"Belmonte","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1073\/pnas.1103509108","article-title":"Efficient Generation of Transgene-Free Human Induced Pluripotent Stem Cells (IPSCs) by Temperature-Sensitive Sendai Virus Vectors","volume":"108","author":"Ban","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"620","DOI":"10.5966\/sctm.2013-0151","article-title":"Intrastriatal Transplantation of Adenovirus-Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington\u2019s Disease","volume":"3","author":"Fink","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"ref_214","unstructured":"Center for iPS Cell Research and Application (CiRA), K.U. (2024, September 04). IPS Cell Stock for Regenerative Medicine. Available online: https:\/\/www.cira.kyoto-u.ac.jp\/e\/research\/stock.html."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Cyranoski, D. (2017). Japanese Man Is First to Receive \u201creprogrammed\u201d Stem Cells from Another Person. Nature.","DOI":"10.1038\/nature.2017.21730"},{"key":"ref_216","first-page":"1","article-title":"Viral Vectors: A Look Back and Ahead on Gene Transfer Technology","volume":"36","author":"Vannucci","year":"2013","journal-title":"New Microbiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.1088547","article-title":"LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1","volume":"302","author":"Schmidt","year":"2003","journal-title":"Science"}],"updated-by":[{"DOI":"10.3390\/ijms262210879","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000}}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3063\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:49:50Z","timestamp":1762775390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":217,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["ijms26073063"],"URL":"https:\/\/doi.org\/10.3390\/ijms26073063","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]}}}