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Oxidative stress, neuroinflammation, and neurotransmitter dysregulation, particularly affecting acetylcholine (ACh) and monoamines, are key hallmarks of these conditions. The current therapeutic strategies targeting cholinergic and monoaminergic systems have some limitations, highlighting the need for novel approaches. Metallodrugs, especially ruthenium and platinum complexes, are gaining attention for their therapeutic use. Among metal complexes, gold(I) and silver(I) N-heterocyclic carbene (NHC) complexes exhibit several biological activities, but their application in NDDs, particularly as monoamine oxidase (MAO) inhibitors, remains largely unexplored. To advance the understanding of this field, we designed, synthesized, and evaluated the biological activity of a new series of Au(I) and Ag(I) complexes stabilized by NHC ligands and bearing a carboxylate salt of tert-butyloxycarbonyl (Boc)-N-protected proline as an anionic ligand. Through in silico and in vitro studies, we assessed their potential as acetylcholinesterase (AChE) and MAO inhibitors, as well as their antioxidant and anti-inflammatory properties, aiming to contribute to the development of potential novel therapeutic agents for NDD management.<\/jats:p>","DOI":"10.3390\/ijms26136116","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:55:13Z","timestamp":1750920913000},"page":"6116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Au(I)- and Ag(I)-NHC Complexes with N-Boc-Protected Proline as Potential Candidates for Neurodegenerative Disorders"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1386-3601","authenticated-orcid":false,"given":"Jessica","family":"Ceramella","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9246-5523","authenticated-orcid":false,"given":"Assunta","family":"D\u2019Amato","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}]},{"given":"Francesca","family":"Procopio","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute, Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-838X","authenticated-orcid":false,"given":"Annaluisa","family":"Mariconda","sequence":"additional","affiliation":[{"name":"Department of Basic and Applied Sciences (DISBA), University of Basilicata, Via Dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-9808","authenticated-orcid":false,"given":"Daniel","family":"Chavarria","sequence":"additional","affiliation":[{"name":"CIQUP-IMS\u2014Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto, Institute of Molecular Sciences, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-7118","authenticated-orcid":false,"given":"Domenico","family":"Iacopetta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-8161","authenticated-orcid":false,"given":"Francesco","family":"Ortuso","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute, Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro, Viale Europa, 88100 Catanzaro, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-1093","authenticated-orcid":false,"given":"Pasquale","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"MedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"Department of Biomedicine-Pharmacology and Therapeutics Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-8931","authenticated-orcid":false,"given":"Maria Stefania","family":"Sinicropi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ateleanu, D.M., Niculescu, A.-G., Lungu, I.I., Radu, C.I., Vlad\u00e2cenco, O., Roza, E., Cost\u0103chescu, B., Grumezescu, A.M., and Teleanu, R.I. (2022). An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115938"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Olufunmilayo, E.O., Gerke-Duncan, M.B., and Holsinger, R.M.D. (2023). Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants, 12.","DOI":"10.3390\/antiox12020517"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Teleanu, R.I., Niculescu, A.-G., Roza, E., Vlad\u00e2cenco, O., Grumezescu, A.M., and Teleanu, D.M. (2022). Neurotransmitters\u2014Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115954"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0047-6374(01)00309-8","article-title":"Acetylcholinesterase in Alzheimer\u2019s disease","volume":"122","author":"Talesa","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhou, S., and Huang, G. (2022). The biological activities of butyrylcholinesterase inhibitors. Biomed. Pharmacother., 146.","DOI":"10.1016\/j.biopha.2021.112556"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Finberg, J.P.M., and Rabey, J.M. (2016). Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00340"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbi.2013.11.012","article-title":"Effect of Cd, Zn and Hg complexes of barbituric acid and thiouracil on rat brain monoamine oxidase-B (in vitro)","volume":"208","author":"Shaban","year":"2014","journal-title":"Chem.-Biol. Interact."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"123389","DOI":"10.1016\/j.jorganchem.2024.123389","article-title":"Role of organometallic complexes in targeted therapies of different diseases: Infectious diseases, cancer and neurodegenerative Diseases","volume":"1022","author":"Nitin","year":"2024","journal-title":"J. Organomet. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sales, T.A., Prandi, I.G., de Castro, A.A., Leal, D.H.S., da Cunha, E.F.F., Kuca, K., and Ramalho, T.C. (2019). Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081829"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2401991","DOI":"10.1002\/adhm.202401991","article-title":"Transition Metal Complexes as Therapeutics: A New Frontier in Combatting Neurodegenerative Disorders through Protein Aggregation Modulation","volume":"13","author":"Navale","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1021\/acsmedchemlett.3c00360","article-title":"NHC-Ag(I) and NHC-Au(I) Complexes with N-Boc-Protected \u03b1-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells","volume":"14","author":"Iacopetta","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Johnson, N.A., Southerland, M.R., and Youngs, W.J. (2017). Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts. Molecules, 22.","DOI":"10.3390\/molecules22081263"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e202200345","DOI":"10.1002\/cmdc.202200345","article-title":"N-Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin","volume":"17","author":"Mariconda","year":"2022","journal-title":"ChemMedChem"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1039\/C8CS00570B","article-title":"Recent advances in gold\u2013NHC complexes with biological properties","volume":"48","author":"Mora","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e6312","DOI":"10.1002\/aoc.6312","article-title":"Silver N-heterocyclic carbene complexes bearing fluorinated benzyl group: Synthesis, characterization, crystal structure, computational studies, and inhibitory properties against some metabolic enzymes","volume":"35","author":"Bal","year":"2021","journal-title":"Appl. Organomet. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114866","DOI":"10.1016\/j.poly.2020.114866","article-title":"Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compounds","volume":"193","author":"Kaya","year":"2021","journal-title":"Polyhedron"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"130399","DOI":"10.1016\/j.molstruc.2021.130399","article-title":"New silver Nheterocyclic carbenes complexes: Synthesis, molecular docking study and biological activities evaluation as cholinesterase inhibitors and antimicrobials","volume":"1238","author":"Lasmari","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.pnpbp.2007.06.005","article-title":"Proline-rich polypeptides in Alzheimer\u2019s disease and neurodegenerative disorders\u2014Therapeutic potential or a mirage?","volume":"31","author":"Gladkevich","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.brainresbull.2011.08.003","article-title":"Neuroprotective action of proline-rich polypeptide-1 in \u03b2-amyloid induced neurodegeneration in rats","volume":"86","author":"Yenkoyan","year":"2011","journal-title":"Brain Res. Bull."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sirignano, M., D\u2019Amato, A., Costabile, C., Mariconda, A., Crispini, A., Scarpelli, F., and Longo, P. (2023). Hydroamination of alkynes catalyzed by NHC-Gold(I) complexes: The non-monotonic effect of substituted arylamines on the catalyst activity. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1260726"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1039\/C5CC00052A","article-title":"Amino acids as chiral anionic ligands for ruthenium based asymmetric olefin metathesis","volume":"51","author":"Ivry","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1039\/b506232b","article-title":"Structure and reactivity of a new anionic N-heterocyclic carbene silver (i) complex","volume":"30","author":"Legault","year":"2005","journal-title":"Chem. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ciardulli, M.C., Mariconda, A., Sirignano, M., Lamparelli, E.P., Longo, R., Scala, P., D\u2019Auria, R., Santoro, A., Guadagno, L., and Della Porta, G. (2023). Activity and Selectivity of Novel Chemical Metallic Complexes with Potential Anticancer Effects on Melanoma Cells. Molecules, 28.","DOI":"10.3390\/molecules28124851"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120486","DOI":"10.1016\/j.ica.2021.120486","article-title":"Silver (I)-N-heterocyclic carbene complexes: Synthesis and characterization, biological evaluation of Anti-Cholinesterase, anti-alpha-amylase, anti-lipase, and antibacterial activities, and molecular docking study","volume":"525","author":"Sandeli","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"ref_26","first-page":"603","article-title":"Novel silver(I)N-heterocyclic carbene complexes bearing 2-(4-hydroxyphenyl)ethyl group: Synthesis, characterization, and enzyme inhibition properties","volume":"58","author":"Kaya","year":"2020","journal-title":"J. Heterocycl. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Behl, T., Kaur, D., Sehgal, A., Singh, S., Sharma, N., Zengin, G., Andronie-Cioara, F.L., Toma, M.M., Bungau, S., and Bumbu, A.G. (2021). Role of Monoamine Oxidase Activity in Alzheimer\u2019s Disease: An Insight into the Therapeutic Potential of Inhibitors. Molecules, 26.","DOI":"10.3390\/molecules26123724"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mateev, E., Georgieva, M., Mateeva, A., Zlatkov, A., Ahmad, S., Raza, K., Azevedo, V., and Barh, D. (2023). Structure-Based Design of Novel MAO-B Inhibitors: A Review. Molecules, 28.","DOI":"10.3390\/molecules28124814"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0162-0134(03)00096-5","article-title":"Effect of cadmium and zinc ethanolamine complexes on rat brain monoamine oxidase-B activity in vitro","volume":"95","author":"Shaban","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms Underlying Inflammation in Neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3810\/pgm.2014.07.2787","article-title":"Role of Indomethacin in Acute Pain and Inflammation Management: A Review of the Literature","volume":"126","author":"Nalamachu","year":"2015","journal-title":"Postgrad. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"110570","DOI":"10.1016\/j.mcat.2019.110570","article-title":"New NHC- silver and gold complexes active in A3-coupling (aldehyde-alkyne-amine) reaction","volume":"480","author":"Mariconda","year":"2020","journal-title":"Mol. Catal."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.4155\/fmc-2016-0160","article-title":"Heterocyclic Carbene Complexes of Silver and Gold as Novel Tools Against Breast Cancer Progression","volume":"8","author":"Saturnino","year":"2016","journal-title":"Future Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Oliveira, C., Cagide, F., Teixeira, J., Amorim, R., Sequeira, L., Mesiti, F., Silva, T., Garrido, J., Remi\u00e3o, F., and Vilar, S. (2018). Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors. Front. Chem., 6.","DOI":"10.3389\/fchem.2018.00126"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molstruc.2019.01.060","article-title":"Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation","volume":"1182","author":"Chavarria","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Mariconda, A., Iacopetta, D., Sirignano, M., Ceramella, J., D\u2019Amato, A., Marra, M., Pellegrino, M., Sinicropi, M.S., Aquaro, S., and Longo, P. (2024). Silver and Gold Complexes with NHC-Ligands Derived from Caffeine: Catalytic and Pharmacological Activity. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052599"},{"key":"ref_37","unstructured":"(2024, December 02). Schr\u00f6dinger Release 2024-1: Maestro, Schr\u00f6dinger LLC. Available online: www.schrodinger.com."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1002\/qua.24481","article-title":"Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences","volume":"113","author":"Bochevarov","year":"2013","journal-title":"Int. J. Quantum Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Kobe, B., Levy-Assaraf, M., Voronov-Goldman, M., Rozman Grinberg, I., Weiserman, G., Shimon, L.J.W., Jindou, S., Borovok, I., White, B.A., and Bayer, E.A. (2013). Crystal Structure of an Uncommon Cellulosome-Related Protein Module from Ruminococcus flavefaciens That Resembles Papain-Like Cysteine Peptidases. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056138"},{"key":"ref_41","first-page":"119","article-title":"The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and In Vivo Activity","volume":"61","author":"Brus","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1073\/pnas.0710626105","article-title":"Structure of human monoamine oxidase A at 2.2-\u212b resolution: The control of opening the entry for substrates\/inhibitors","volume":"105","author":"Son","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1021\/acs.jmedchem.8b00357","article-title":"Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis","volume":"61","author":"Reis","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nchembio.115","article-title":"Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase","volume":"4","author":"Garcin","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"14453","DOI":"10.1039\/C5DT00557D","article-title":"Aromatic amine N-oxide organometallic compounds: Searching for prospective agents against infectious diseases","volume":"44","author":"Mosquillo","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_47","unstructured":"Forum, A. (2024, December 02). ADL, Parameters for Docking with Metal Ions in Receptor. Available online: https:\/\/www.researchgate.net\/profile\/Dr-Rajesh-Patil\/post\/Autodock-docking-with-gold-nanoparticles\/attachment\/59d6477f79197b80779a2567\/AS%3A462677517574144%401487322324251\/download\/ADL_+Parameters+for+docking+with+metal+ions+in+receptor.pdf."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:58:37Z","timestamp":1760032717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":47,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26136116"],"URL":"https:\/\/doi.org\/10.3390\/ijms26136116","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]}}}