{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:06Z","timestamp":1760060706602,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"EU Horizon 2020 program","doi-asserted-by":"publisher","award":["774548\u2013STOP-H2020-SFS-2016-2017\/H2020-SFS-2017-2","CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["774548\u2013STOP-H2020-SFS-2016-2017\/H2020-SFS-2017-2","CIBEROBN CB12\/03\/30038"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"European Regional Development Fund, and IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI)","doi-asserted-by":"publisher","award":["774548\u2013STOP-H2020-SFS-2016-2017\/H2020-SFS-2017-2","CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["774548\u2013STOP-H2020-SFS-2016-2017\/H2020-SFS-2017-2","CIBEROBN CB12\/03\/30038"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The prevalence of childhood obesity has risen significantly, with numerous associated health risks. Emerging research suggests a potential role for genetic factors; particularly, copy number variations (CNVs) of the amylase 1 gene (AMY1) may influence obesity through dietary behavior and metabolic regulation. This study aimed to examine the relationship between BMI z-score, dietary intake, and salivary AMY1 gene copy number (CN) in children with overweight and obesity, and to assess the relationship between AMY1 CN and the impact of lifestyle intervention on these parameters. The study included 90 children aged 2\u20136 years with overweight or obesity. Participants were randomized into either a parent support intervention group or a standard care control group. Anthropometric measurements, dietary intake, and salivary AMY1 gene copy number were assessed at baseline and after a 9-month intervention. Positive correlations were found between AMY1 gene copy number, BMI z-score, and carbohydrate intake, suggesting a potential role of this gene in dietary behavior-related obesity. The parent support intervention led to significant reductions in children\u2019s BMI, BMI z-score, and energy and macronutrient intake compared to standard care. Although there was no direct association between AMY1 copy number and changes in BMI z-score, higher AMY1 copy numbers were associated with greater reductions in polyunsaturated fatty acid intake. These findings highlight an interaction between salivary AMY1 gene copy number, dietary intake, and obesity in children. These results support the relevance of genetic factors in obesity-related dietary patterns and emphasize the effectiveness of targeted family-based lifestyle interventions.<\/jats:p>","DOI":"10.3390\/ijms26189059","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:10:19Z","timestamp":1758118219000},"page":"9059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Amylase Gene Copy Number Relates with BMI Z-Score and with Response to Lifestyle Intervention for Children with Overweight and Obesity"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-135X","authenticated-orcid":false,"given":"Margalida","family":"Monserrat-Mesquida","sequence":"first","affiliation":[{"name":"Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-8461","authenticated-orcid":false,"given":"Cristina","family":"Bouzas","sequence":"additional","affiliation":[{"name":"Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-607X","authenticated-orcid":false,"given":"H\u00e9lia","family":"Cardoso","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture Environment and Development, University of \u00c9vora, 7004-516 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-1588","authenticated-orcid":false,"given":"Silvia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]},{"given":"Emma","family":"Argelich","sequence":"additional","affiliation":[{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]},{"given":"David","family":"Mateos","sequence":"additional","affiliation":[{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]},{"given":"Monica","family":"Marques","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture Environment and Development, University of \u00c9vora, 7004-516 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-1338","authenticated-orcid":false,"given":"Catarina","family":"Campos","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture Environment and Development, University of \u00c9vora, 7004-516 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-1337","authenticated-orcid":false,"given":"Elsa","family":"Lamy","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture Environment and Development, University of \u00c9vora, 7004-516 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-0761","authenticated-orcid":false,"given":"Josep A.","family":"Tur","sequence":"additional","affiliation":[{"name":"Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain"},{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2025, July 12). 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