{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:49Z","timestamp":1760060749303,"version":"build-2065373602"},"reference-count":58,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MESRSI and CNRST","award":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"],"award-info":[{"award-number":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"]}]},{"name":"FCT","award":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"],"award-info":[{"award-number":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"]}]},{"name":"PRR and European Funds NextGeneration EU","award":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"],"award-info":[{"award-number":["PPR2-35\/2016","PTDC\/QEQ-QAN\/5955\/2014","PTDC\/QUI-QFI\/2870\/2020","UIDB\/00081\/2020","LA\/P\/0056\/2020","UIDB\/04423\/2020","UIDP\/04423\/2020","UID\/04033\/2023","LA\/P\/0126\/2020","CEECINST\/00069\/2021","BIPD\/UTAD\/3\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Polypore mushrooms have been widely recognized for centuries for their use in food and medicine due to their strong capacity to produce numerous biomolecules with beneficial effects on human health. Fomes fomentarius is one such species that remains poorly explored, particularly when growing in Morocco. Herein, this study aimed to characterize the bioactive compounds of F. fomentarius and evaluate its pharmacological properties. Spectrophotometric analysis showed that F. fomentarius revealed high levels of total phenolics (75.83 mg GAE\/g dme) and flavonoids (37.62 mg CE\/g dme). Gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis identified 109 volatile and non-volatile compounds, primarily sugars (24), fatty acids (23), alcohols (10), organic acids (9), and terpenoids (6). In addition, liquid chromatography-mass spectrometry (LC-MS) analysis allowed the identification of 24 phenolic compounds, with isorhamnetin (2734.00 \u00b5g\/g), p-hydroxybenzoic acid (409.00 \u00b5g\/g), and kaempferol (351.10 \u00b5g\/g) as the most abundant. Regarding pharmacological properties, F. fomentarius extract demonstrated strong antioxidant activity, with the DPPH radical-scavenging assay showing the highest potency, followed by \u03b2-carotene bleaching inhibition and ferric ion-reducing power, with EC50 (half maximal effective concentration) values of 114.40, 174.50, and 250.70 \u00b5g\/mL, respectively. Additionally, it exhibited broad-spectrum antimicrobial activity against all seven human pathogenic microorganisms, with Epidermophyton floccosum being the most susceptible ((minimum inhibitory concentration (MIC)) = 2 mg\/mL and minimal fungicidal concentration (MFC) = 4 mg\/mL) and A. fumigatus the most resistant (MIC = 26.67 mg\/mL and MFC \u2265 64 mg\/mL). Overall, the result indicated that Moroccan F. fomentarius is a rich source of diverse bioactive compounds with potent antioxidant and antimicrobial activities, supporting its potential for various applications.<\/jats:p>","DOI":"10.3390\/ijms26189215","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:04:44Z","timestamp":1758546284000},"page":"9215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Compounds and Pharmacological Properties of the Polypore Fomes fomentarius, a Medicinal Wild Mushroom Collected from Morocco"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-9278","authenticated-orcid":false,"given":"El Hadi","family":"Erbiai","sequence":"first","affiliation":[{"name":"Centre for the Research and Technology of Agroenvironmental and Biological Sciences, CITAB, Inov4Agro, Universidadede Tr\u00e1s-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal"},{"name":"Biology, Environment, and Sustainable Development Laboratory, \u00c9cole Normale Sup\u00e9rieure de T\u00e9touan (ENS), Abdelmalek Essaadi University, Tetouan 93000, Morocco"},{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Spatial Plannings, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Safae","family":"Maouni","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, \u00c9cole Normale Sup\u00e9rieure de T\u00e9touan (ENS), Abdelmalek Essaadi University, Tetouan 93000, Morocco"},{"name":"Department of Dermatology, Mohamed 5 University, Rabat B.P. 6527, Morocco"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-8455","authenticated-orcid":false,"given":"Lu\u00eds","family":"Pinto da Silva","sequence":"additional","affiliation":[{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Spatial Plannings, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Rabah","family":"Saidi","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, \u00c9cole Normale Sup\u00e9rieure de T\u00e9touan (ENS), Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"given":"Zouhaire","family":"Lamrani","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, \u00c9cole Normale Sup\u00e9rieure de T\u00e9touan (ENS), Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-3441","authenticated-orcid":false,"given":"Joaquim C. G.","family":"Esteves da Silva","sequence":"additional","affiliation":[{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Geosciences, Environment and Spatial Plannings, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9280-3596","authenticated-orcid":false,"given":"Abdelfettah","family":"Maouni","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, \u00c9cole Normale Sup\u00e9rieure de T\u00e9touan (ENS), Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-5809","authenticated-orcid":false,"given":"Eug\u00e9nia","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kumar, A., Singh, J., and Samuel, J. 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