{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:50:34Z","timestamp":1791615034200,"version":"4.3.4"},"reference-count":129,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hong Kong Research Grants Council","award":["17125323"],"award-info":[{"award-number":["17125323"]}]},{"name":"Hong Kong Research Grants Council","award":["17125524"],"award-info":[{"award-number":["17125524"]}]},{"name":"Hong Kong Research Grants Council","award":["17125925"],"award-info":[{"award-number":["17125925"]}]},{"name":"HKU Seed Funds","award":["2502251990"],"award-info":[{"award-number":["2502251990"]}]},{"name":"HKU Seed Funds","award":["2402101703"],"award-info":[{"award-number":["2402101703"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Mol. Sci.","IJMS"],"abstract":"<jats:p>Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide and remains associated with high morbidity and mortality. In DKD, glycolytic reprogramming is triggered by hyperglycemia, hypoxia, oxidative stress, and inflammatory activation, which converge to drive metabolic imbalance. These stimuli promote excessive glycolytic flux, lactate accumulation, and diverse post-translational modifications, thereby reinforcing pathological reactions such as epithelial\u2013mesenchymal transition, inflammation, and renal fibrosis. Accumulating evidence indicates that glycolytic alterations in DKD are highly cell type-specific. In podocytes, impaired glycolysis disrupts actin cytoskeletal integrity, promotes foot process fusion\/effacement, and compromises the glomerular filtration barrier, ultimately leading to proteinuria. In tubular epithelial cells, glycolysis drives mesenchymal transformation and fibrogenesis, and engages in crosstalk with macrophages. In mesangial cells, glycolysis promotes mesangial cell hypertrophy and contributes to mesangial expansion. Mechanistically, central regulators including HIF-1\u03b1 and PKM2, are modulated through glycolysis associated mechanisms, linking glycolysis to mitochondrial dysfunction, pathological cellular phenotypes, and DKD progression. Therapeutically, SGLT2 inhibitors have been clinically applied for DKD and kidney protection. Clinical studies further show that they can suppress maladaptive glycolytic activation in human metabolic analysis. Collectively, current evidence highlights glycolysis as a key driver of DKD and therapeutic targets for DKD management.<\/jats:p>","DOI":"10.3390\/ijms27198793","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:36:31Z","timestamp":1790786191000},"page":"8793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Glycolysis in Diabetic Kidney Disease"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-9719","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"},{"name":"School of Chinese Medicine, The University of Hong Kong, Hong Kong 999000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7950-3897","authenticated-orcid":false,"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, The University of Hong Kong, Hong Kong 999000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Cui","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongke","family":"You","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, 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Chinese Medicine, The University of Hong Kong, Hong Kong 999000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, The University of Hong Kong, Hong Kong 999000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, The University of Hong Kong, Hong Kong 999000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quantitative Synthetic Biology, Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, 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