{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:27:50Z","timestamp":1777987670341,"version":"3.51.4"},"reference-count":76,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Research Councils, Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["Edital PQ 06\/2019"],"award-info":[{"award-number":["Edital PQ 06\/2019"]}]},{"name":"Brazilian Research Councils, Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["309482\/2019-4"],"award-info":[{"award-number":["309482\/2019-4"]}]},{"name":"Brazilian Research Councils, Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["CAPES-PROEX, 001"],"award-info":[{"award-number":["CAPES-PROEX, 001"]}]},{"name":"Brazilian Research Councils, Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["UIDB\/00313\/2020"],"award-info":[{"award-number":["UIDB\/00313\/2020"]}]},{"name":"Brazilian Research Councils, Conselho Nacional do Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["UIDP\/00313\/2020"],"award-info":[{"award-number":["UIDP\/00313\/2020"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["Edital PQ 06\/2019"],"award-info":[{"award-number":["Edital PQ 06\/2019"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["309482\/2019-4"],"award-info":[{"award-number":["309482\/2019-4"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["CAPES-PROEX, 001"],"award-info":[{"award-number":["CAPES-PROEX, 001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["UIDB\/00313\/2020"],"award-info":[{"award-number":["UIDB\/00313\/2020"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["UIDP\/00313\/2020"],"award-info":[{"award-number":["UIDP\/00313\/2020"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["Edital PQ 06\/2019"],"award-info":[{"award-number":["Edital PQ 06\/2019"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["309482\/2019-4"],"award-info":[{"award-number":["309482\/2019-4"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["CAPES-PROEX, 001"],"award-info":[{"award-number":["CAPES-PROEX, 001"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["UIDB\/00313\/2020"],"award-info":[{"award-number":["UIDB\/00313\/2020"]}]},{"name":"Portuguese Agency for Scientific Research, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["UIDP\/00313\/2020"],"award-info":[{"award-number":["UIDP\/00313\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inorganics"],"abstract":"<jats:p>This study sought to investigate the synthesis of eight complexes constituted by a cobalt(III) (CoIII) metallic center coordinated to two units of iminic ligands LnC (n = 1\u20134, L1C\u2013L4C), which are derivatives of pyridoxal hydrochloride and anilines with thioether function containing one to four carbons. Depending on the source of the cobalt ion and the addition (or not) of a non-coordinating counterion, complexes with distinct structures may form, being categorized into two series: [CoIII(LnC)(L0C)] (n = 1\u20134, C1\u2019\u2013C4\u2019) with a LnC ligand and a ligand that has a thiolate function which cleaves the C-S(thioether) bond (L0C) and [CoIII(LnC)2]PF6 (n = 1\u20134, C1\u2013C4) with two similar units of the same LnC ligand. The occurrence (or not) of cleavage in the eight complexes was observed by elucidating the solid-state structures by single crystal X-ray diffraction. This exciting method allows the synthesis of CoIII complexes without cleaving the C-S bonds from the ligands, thereby not requiring an inert atmosphere in the reaction systems. The synthesized complexes were evaluated by in silico calculations on viable biological targets such as deoxyribonucleic acid, superoxide dismutase enzyme, human serum albumin, and the structural spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the receptor binding domain (RBD) in both up and down conformations without and in complex with the cellular receptor angiotensin-converting enzyme 2 (ACE2). Overall, in silico results suggested that all the inorganic complexes under study are potential anticancer\/antiviral agents; however, C4 and C4\u2019 are the best candidates for future in vitro assays.<\/jats:p>","DOI":"10.3390\/inorganics12060171","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:11:28Z","timestamp":1718709088000},"page":"171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis of Cobalt(III) Complexes Derived from Pyridoxal: Structural Cleavage Evaluations and In Silico Calculations for Biological Targets"],"prefix":"10.3390","volume":"12","author":[{"given":"Liniquer Andr\u00e9","family":"Fontana","sequence":"first","affiliation":[{"name":"Institute of Chemistry, University of Campinas, Rua Josu\u00e9 de Castro, Cidade Universit\u00e1ria Zeferino Vaz, Campinas 13083-970, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-3964","authenticated-orcid":false,"given":"Francisco Mainardi","family":"Martins","sequence":"additional","affiliation":[{"name":"Inorganic Materials Laboratory, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-0375","authenticated-orcid":false,"given":"Josi\u00e9li Demetrio","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Inorganic Materials Laboratory, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-0110","authenticated-orcid":false,"given":"Carlos","family":"Serpa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Coimbra Chemistry Centre\u2014Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga s\/n, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-7659","authenticated-orcid":false,"given":"Ot\u00e1vio Augusto","family":"Chaves","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Coimbra Chemistry Centre\u2014Institute of Molecular Science (CQC-IMS), University of Coimbra, Rua Larga s\/n, 3004-535 Coimbra, Portugal"},{"name":"Laboratory of Immunopharmacology, Centro de Pesquisa, Inova\u00e7\u00e3o e Vigil\u00e2ncia em COVID-19 e Emerg\u00eancias Sanit\u00e1rias (CPIV), Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-361, RJ, Brazil"}]},{"given":"Davi Fernando","family":"Back","sequence":"additional","affiliation":[{"name":"Inorganic Materials Laboratory, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120096","DOI":"10.1016\/j.ica.2020.120096","article-title":"Synthesis of new rhodium(III) complex by benzylic CS bond cleavage of thioether containing NNS donor Schiff base ligand: Investigation of catalytic activity towards transfer hydrogenation of ketones","volume":"515","author":"Biswas","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1039\/C2CS35323G","article-title":"Transition-metal mediated carbon\u2013sulfur bond activation and transformations","volume":"42","author":"Wang","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1039\/C9CS00837C","article-title":"Transition-metal mediated carbon\u2013sulfur bond activation and transformations: An update","volume":"49","author":"Lou","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e202101107","DOI":"10.1002\/ejic.202101107","article-title":"M(II) (M=Cu, Ni) Assisted C\u2212S bond cleavage and oxidative dehydrogenation of amine on non-innocent salen type ligand platforms by varying nitrogen vs. sulfur coordination atoms","volume":"11","author":"Bag","year":"2022","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1074\/jbc.M115.636761","article-title":"The reaction mechanism of methyl-coenzyme M reductase","volume":"290","author":"Wongnate","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.inoche.2015.01.018","article-title":"Synthesis and characterization of palladium(II) complex of Schiff base ligand: CS bond cleavage and catalytic activity","volume":"53","author":"Pattanayak","year":"2015","journal-title":"Inorg. Chem. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molstruc.2017.04.044","article-title":"Synthesis of palladium(II) complex with NNS donor Schiff base ligand via C S bond cleavage: X-ray structure, electrochemistry and DFT computation","volume":"1142","author":"Biswas","year":"2017","journal-title":"J. Mol. Struct."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1021\/acs.organomet.9b00524","article-title":"Iron-SNS and -CNS complexes: Selective caryl\u2013S bond cleavage and amine-borane dehydrogenation catalysis","volume":"38","author":"Elsby","year":"2019","journal-title":"Organometallics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.poly.2018.10.061","article-title":"Synthesis of a rhodium(III) triphenylphosphine complex via C S bond cleavage of an azo-thioether ligand: X-ray structure, electrochemistry and catalysis towards transfer hydrogenation of ketones","volume":"158","author":"Roy","year":"2019","journal-title":"Polyhedron"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1039\/c3dt50422k","article-title":"Cleavage of the C\u2013S bond with the formation of a binuclear copper complex with 2-thiolato-3-phenyl-5-(pyridine-2-ylmethylene)-3,5-dihydro-4H-imidazole-4-one. A new mimic of the active site of N2O reductase","volume":"42","author":"Majouga","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1021\/om00036a005","article-title":"Ring-size specific transformations of cobalt(III)-thioether chelates activated by base. Co-C formation or C-S cleavage?","volume":"12","author":"Chakraborty","year":"1993","journal-title":"Organometallics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/ic00082a033","article-title":"New cobalt complexes incorporating thioether chelation and base-induced homolog-selective transformations thereof","volume":"33","author":"Chakraborty","year":"1994","journal-title":"Inorg. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1387-7003(02)00522-1","article-title":"C\u2013S bond cleavage by cobalt: Synthesis, characterization and crystal structure determination of 1,2-di-(o-salicylaldiminophenylthio)ethane and its Co(III) product with C\u2013S bond cleaved fragments","volume":"5","author":"Rajsekhar","year":"2002","journal-title":"Inorg. Chem. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/B305313J","article-title":"Complexation behaviour of hexadentate ligands possessing N2O4 and N2O2S2 cores: Differential reactivity towards Co(II), Ni(II) and Zn(II) salts and structures of the products","volume":"28","author":"Rajsekhar","year":"2004","journal-title":"New J. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1039\/B709901K","article-title":"Cobalt(II) and cobalt(III) complexes of thioether-containing hexadentate pyrazine amide ligands: C\u2013S bond cleavage and cyclometallation reaction","volume":"14","author":"Singh","year":"2008","journal-title":"Dalton Trans."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cleave, C.V., and Crans, D.C. (2019). The first-row transition metals in the periodic table of medicine. Inorganics, 7.","DOI":"10.3390\/inorganics7090111"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Osman, D., Cooke, A., Young, T.R., Deery, E., Robinson, N.J., and Warren, M.J. (2021). The requirement for cobalt in vitamin B12: A paradigm for protein metalation. Biochim. Biophys. Acta Mol. Cell Res., 1868.","DOI":"10.1016\/j.bbamcr.2020.118896"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ge, Y., Zadeh, M., and Mohamadzadeh, M. (2022). Vitamin B12 regulates the transcriptional, metabolic, and epigenetic programing in human ileal epithelial cells. Nutrients, 14.","DOI":"10.3390\/nu14142825"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jimd.12009","article-title":"Vitamin B12, folate, and the methionine remethylation cycle\u2014Biochemistry, pathways, and regulation","volume":"42","author":"Froese","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ccr.2017.11.027","article-title":"Harnessing the properties of cobalt coordination complexes for biological application","volume":"375","author":"Renfrew","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1002\/anie.201900163","article-title":"Organic imine cages: Molecular marriage and applications","volume":"58","author":"Acharyya","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1021\/acs.inorgchem.9b03259","article-title":"Unusually distorted pseudo-octahedral coordination environment around CoII from thioether Schiff base ligands in dinuclear [CoLn] (Ln = La, Gd, Tb, Dy, Ho) complexes: Synthesis, structure, and understanding of magnetic behavior","volume":"59","author":"Basak","year":"2020","journal-title":"Inorg. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.inoche.2015.10.027","article-title":"Pro-oxidant activity of nickel (II) pyridoxal complexes. Synthesis, characterization and peroxidase activity assays","volume":"62","author":"Fontana","year":"2015","journal-title":"Inorg. Chem. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1039\/C9CY01210A","article-title":"PLP-dependent enzymes as important biocatalysts for the pharmaceutical, chemical and food industries: A structural and mechanistic perspective","volume":"9","author":"Rocha","year":"2019","journal-title":"Catal. Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1016\/j.ccr.2012.07.001","article-title":"Coordination chemistry of vitamin B6 and derivatives: A structural overview","volume":"256","author":"Casas","year":"2012","journal-title":"Coord. Chem. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ica.2009.11.007","article-title":"Synthesis, X-ray crystal structures and spectroscopic properties of two Ni(II) complexes of pyridoxal Schiff\u2019s bases with diamines: Importance of steric factor in stabilization of water helices in the lattices of metal complex","volume":"363","author":"Naskar","year":"2010","journal-title":"Inorg. Chim. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Siqueira, J.D., de Pellegrin, S.F., dos Santos, S.S., Iglesias, B.A., Piquini, P.C., Arantes, L.P., Soares, F.A., Chaves, O.A., Neves, A., and Back, D.F. (2020). SOD activity of new copper II complexes with ligands derived from pyridoxal and toxicity in Caenorhabditis elegans. J. Inorg. Biochem., 204.","DOI":"10.1016\/j.jinorgbio.2019.110950"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1039\/D0SC04082G","article-title":"Metallodrugs are unique: Opportunities and challenges of discovery and development","volume":"11","author":"Anthony","year":"2020","journal-title":"Chem. Sci."},{"key":"ref_29","first-page":"100935","article-title":"Synthesis, biological and medicinal impacts of metallodrugs: A study","volume":"5","author":"Kabir","year":"2023","journal-title":"Res. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Szefler, B., and Czele\u0144, P. (2023). Will the Interactions of Some Platinum (II)-Based Drugs with B-Vitamins Reduce Their Therapeutic Effect in Cancer Patients? Comparison of Chemotherapeutic Agents such as Cisplatin, Carboplatin and Oxaliplatin\u2014A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021548"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1021\/acs.inorgchem.3c01172","article-title":"Effects of bis(imino)acenaphthene (bian)-derived ligands on the cytotoxicity, DNA interactions, and redox activity of palladium(II) bipyridine complexes","volume":"62","author":"Komlyagina","year":"2023","journal-title":"Inorg. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1021\/acs.jmedchem.1c01248","article-title":"Pt(II)-NHC complex induces ROS-ERS-related DAMP balance to harness immunogenic cell death in hepatocellular carcinoma","volume":"65","author":"Bian","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Phan, T.T.V., Huynh, T.-C., Manivasagan, P., Mondal, S., and Oh, J. (2020). An up-to-date review on biomedical applications of palladium nanoparticles. Nanomaterials, 10.","DOI":"10.3390\/nano10010066"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mirzaei, S., Hushmandi, K., Zabolian, A., Saleki, H., Torabi, S.M.R., Ranjbar, A., SeyedSaleh, S., Sharifzadeh, S.O., Khan, H., and Ashrafizadeh, M. (2021). Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: A focus on molecular pathways and possible therapeutic strategies. Molecules, 26.","DOI":"10.3390\/molecules26082382"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s12276-020-0384-2","article-title":"ROS in cancer therapy: The bright side of the moon","volume":"52","author":"Perillo","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"590970","DOI":"10.3389\/fonc.2020.590970","article-title":"Metabolic aspects of palladium(II) potential anti-cancer drugs","volume":"12","author":"Carneiro","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biochi.2023.05.014","article-title":"Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?","volume":"213","author":"Jahankhani","year":"2023","journal-title":"Biochimie"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e28722","DOI":"10.1002\/jmv.28722","article-title":"Causal effects of COVID-19 on cancer risk: A Mendelian randomization study","volume":"95","author":"Li","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2217\/epi-2023-0052","article-title":"COVID-19 and cancer: Insights into their association and influence on genetic and epigenetic landscape","volume":"15","author":"Ghosh","year":"2023","journal-title":"Epigenomics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/acscentsci.3c01340","article-title":"Metals in cancer research: Beyond platinum metallodrugs","volume":"10","author":"Casini","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"214104","DOI":"10.1016\/j.ccr.2021.214104","article-title":"Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives","volume":"445","author":"Yousuf","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"115890","DOI":"10.1016\/j.poly.2022.115890","article-title":"A concise review on cobalt Schiff base complexes as anticancer agents","volume":"222","author":"Kar","year":"2022","journal-title":"Polyhedron"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Smilowicz, D., and Metzler-Nolte, N. (2020). Bioconjugates of Co(III) complexes with Schiff base ligands and cell penetrating peptides: Solid phase synthesis, characterization and antiproliferative activity. J. Inorg. Biochem., 206.","DOI":"10.1016\/j.jinorgbio.2020.111041"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00044-023-03068-0","article-title":"Promising Schiff bases in antiviral drug design and discovery","volume":"32","author":"Kaushik","year":"2023","journal-title":"Med. Chem. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3390\/ph3061711","article-title":"Cobalt complexes as antiviral and antibacterial agents","volume":"3","author":"Chang","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Costanzo, M., de Giglio, M.A.R., and Roviello, G.N. (2023). Deciphering the relationship between SARS-CoV-2 and cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097803"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1021\/ic0100572","article-title":"Conversion of azomethine moiety to carboxamido group at cobalt(III) center in model complexes of Co-containing nitrile hydratase","volume":"40","author":"Tyler","year":"2001","journal-title":"Inorg. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1039\/c3cc00277b","article-title":"Inspiration from old molecules: Field-induced slow magnetic relaxation in three air-stable tetrahedral cobalt(ii) compounds","volume":"49","author":"Yang","year":"2013","journal-title":"Chem. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.poly.2013.01.010","article-title":"Synthesis, characterization, structure, redox property, antibacterial and catalytic activity of tridentate Schiff base cobalt(III), nickel(II) and palladium(II) complexes","volume":"51","author":"Pattanayak","year":"2013","journal-title":"Polyhedron"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Chaves, O.A., Rodrigues-Santos, C.E., Echevarria, \u00c1., Sacramento, C.Q., Fintelman-Rodrigues, N., Temerozo, J.R., Castro-Faria-Neto, H.C., and E Souza, T.M.L. (2022). Fluorine atoms on C6H5-corrole affect the interaction with Mpro and PLpro proteases of SARS-CoV-2: Molecular docking and 2D-QSAR approaches. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810936"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10822-007-9165-4","article-title":"Can we use docking and scoring for hit-to-lead optimization?","volume":"22","author":"Enyedy","year":"2008","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2174\/0929867323666161214114948","article-title":"Combination platinum-based and DNA damage response-targeting cancer therapy: Evolution and future directions","volume":"24","author":"Basourakos","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2174\/092986712803414295","article-title":"DNA interstrand cross-linking agents and their chemotherapeutic potential","volume":"19","author":"Brulikova","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1158\/1078-0432.CCR-07-2238","article-title":"Platinum resistance: The role of DNA repair pathways","volume":"14","author":"Martin","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Martins, F.M., Siqueira, J.D., Iglesias, B.A., Chaves, O.A., and Back, D.F. (2022). Pyridoxal water-soluble cobalt(II) helicates: Synthesis, structural analysis, and interactions with biomacromolecules. J. Inorg. Biochem., 233.","DOI":"10.1016\/j.jinorgbio.2022.111854"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.freeradbiomed.2017.08.013","article-title":"Extracellular superoxide dismutase and its role in cancer","volume":"112","author":"Griess","year":"2017","journal-title":"Free Rad. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1021\/cr4005296","article-title":"Superoxide dismutases and superoxide reductases","volume":"114","author":"Sheng","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"120530","DOI":"10.1016\/j.ica.2021.120530","article-title":"Copper (II) complexes derived from pyridoxal: Structural correlations, cytotoxic activities, and molecular docking","volume":"526","author":"Siqueira","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chaves, O.A., Iglesias, B.A., and Serpa, C. (2022). Biophysical characterization of the interaction between a transport human plasma protein and the 5,10,15,20-tetra(pyridine-4-yl)porphyrin. Molecules, 27.","DOI":"10.3390\/molecules27165341"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jphotochemrev.2012.09.001","article-title":"Binding of serum albumins with bioactive substances\u2013Nanoparticles to drugs","volume":"14","author":"Naveenraj","year":"2013","journal-title":"J. Photochem. Photobiol. C"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"112466","DOI":"10.1016\/j.molliq.2020.112466","article-title":"Effect of peripheral platinum(II) bipyridyl complexes on the interaction of tetra-cationic porphyrins with human serum albumin","volume":"301","author":"Chaves","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_63","first-page":"e202200075","article-title":"Synthesis, photophysics, computational approaches, and biomolecule interactive studies of metalloporphyrins containing pyrenyl units: Influence of the metal center","volume":"12","author":"Chaves","year":"2022","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e202104020","DOI":"10.1002\/slct.202104020","article-title":"Interactions of a ruthenium-ketoprofen compound with human serum albumin and DNA: Insights from spectrophotometric titrations and molecular docking calculations","volume":"7","author":"Sarmento","year":"2022","journal-title":"ChemistrySelect"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1039\/D1DT03565G","article-title":"Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(II) and Pd(II) complexes. Insights for photodynamic therapy applications","volume":"51","author":"Tisoco","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e6836","DOI":"10.1002\/aoc.6836","article-title":"Experimental and theoretical studies of new Co(III) complexes of hydrazide derivatives proposed as multi-target inhibitors of SARS-CoV-2","volume":"36","author":"Parvarinezhad","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10534-022-00386-5","article-title":"Metal-based complexes against SARS-CoV-2","volume":"35","author":"Ioannou","year":"2022","journal-title":"Biometals"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"El-Lateef, H.M.A., El-Dabea, T., Khalaf, M.M., and Abu-Dief, A.M. (2022). Development of metal complexes for treatment of coronaviruses. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169360"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41422-021-00490-0","article-title":"Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2","volume":"31","author":"Yan","year":"2021","journal-title":"Cell Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Cryst."},{"key":"ref_71","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1107\/S0021889897003117","article-title":"ORTEP-3 for Windows\u2014A version of ORTEP-III with a Graphical User Interface (GUI)","volume":"30","author":"Farrugia","year":"1997","journal-title":"J. Appl. Cryst."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1073\/pnas.78.4.2179","article-title":"Structure of a B-DNA dodecamer: Conformation and dynamics","volume":"78","author":"Drew","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1006\/bbrc.2002.6540","article-title":"The atomic structure of human methemalbumin at 1.9 \u00c5","volume":"291","author":"Wardell","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"132480","DOI":"10.1016\/j.molstruc.2022.132480","article-title":"Self-association synthesis with ortho-vanillin to promote mono- and heptanuclear complexes and their evaluation as antioxidant agents","volume":"1256","author":"Siqueira","year":"2022","journal-title":"J. Mol. Struct."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Soares, M.A.G., de Aquino, P.A., Costa, T., Serpa, C., and Chaves, O.A. (2024). Insights into the effect of glucose on the binding between human serum albumin and the nonsteroidal anti-inflammatory drug nimesulide. Int. J. Biol. Macromol., 265.","DOI":"10.1016\/j.ijbiomac.2024.131148"}],"container-title":["Inorganics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6740\/12\/6\/171\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:00:28Z","timestamp":1760108428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6740\/12\/6\/171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":76,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["inorganics12060171"],"URL":"https:\/\/doi.org\/10.3390\/inorganics12060171","relation":{},"ISSN":["2304-6740"],"issn-type":[{"value":"2304-6740","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]}}}