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Herein, we aimed to pursue the study of the breast anticancer activity of a mixed-valence polyoxovanadate, [Cl@VV7VIV8O36]6\u2212 (V15) against MCF-7 and MDA-MB-231 cancer cell lines and to analyze its Ca2+-ATPase inhibition potential. 51V NMR and UV-Vis\/NIR studies of V15 indicated its stability in HEPES and RPMI media. For the Ca2+-ATPase activity, V15 showed an IC50 value of 14.2 \u03bcM and a mixed type of inhibition. The electrostatic potential map of V15 and other POMs were correlated with the enzyme activity inhibition. V15 also exhibited cytotoxicity against MDA-MB-231 (IC50 = 17.2 \u03bcM) and MCF-7 (IC50 = 15.1 \u03bcM) breast cancer cell lines. Using V15 concentrations equivalent to half and 1\/4 of the IC50, it was observed that MDA-MB-231 cell migration was reduced by 90 and 70%, after 24 h, respectively. Moreover, V15 caused morphological changes from fusiform to an epithelial-like (amoeboid) shape. Finally, V15 induced the increase in RIPK1, MLKL, and RIPK3 gene expression, up to 3, 10, and 15-fold, respectively, pointing out that the mechanisms of cell death in the triple-negative breast cancer cell line may occur by necroptosis.<\/jats:p>","DOI":"10.3390\/inorganics13090306","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:08:16Z","timestamp":1757678896000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mixed-Valence Pentadecavanadate with Ca2+-ATPase Inhibition Potential and Anti-Breast Cancer Activity"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-0414","authenticated-orcid":false,"given":"Bianca R.","family":"Brito","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6744-5725","authenticated-orcid":false,"given":"Helo\u00edsa de S.","family":"Camilo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-3827","authenticated-orcid":false,"given":"Anderson F. da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"given":"Ronny R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-9418","authenticated-orcid":false,"given":"Eduardo L.","family":"de S\u00e1","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-2508","authenticated-orcid":false,"given":"Carolina","family":"Camargo de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-9292","authenticated-orcid":false,"given":"Gil","family":"Fraqueza","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar, Universidade do Algarve, 8000-139 Faro, Portugal"},{"name":"Instituto Superior de Engenharia, Universidade do Algarve, 8000-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-6178","authenticated-orcid":false,"given":"Giseli","family":"Klassen","sequence":"additional","affiliation":[{"name":"Departamento de Patologia B\u00e1sica, Universidade Federal do Paran\u00e1, Curitiba 82590-300, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3201","authenticated-orcid":false,"given":"Manuel","family":"Aureliano","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar, Universidade do Algarve, 8000-139 Faro, Portugal"},{"name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-2523","authenticated-orcid":false,"given":"Giovana G.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal do Paran\u00e1, Curitiba 81531-980, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1039\/b907581j","article-title":"Decavanadate: A Journey in a Search of a Role","volume":"42","author":"Aureliano","year":"2009","journal-title":"Dalton Trans."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"De Sousa-Coelho, A.L., Aureliano, M., Fraqueza, G., Serr\u00e3o, G., Gon\u00e7alves, J., S\u00e1nchez-Lombardo, I., Link, W., and Ferreira, B.I. 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