{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:44:08Z","timestamp":1777517048925,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inorganics"],"abstract":"<jats:p>The continuous rising of the cancer patient death rate undoubtedly shows the pressure to find more potent and efficient drugs than those in clinical use. These agents only treat a narrow range of cancer conditions with limited success and are associated with serious side effects caused by the lack of selectivity. In this frame, innovative syntheses approaches can decisively contribute to the success of \u201csmart compounds\u201d that might be only selective and\/or active towards the cancer cells, sparing the healthy ones. In this scope, ruthenium chemistry is a rising field for the search of proficient metallodrugs by the use of macromolecular ruthenium complexes (dendrimers and dendronized polymers, coordination-cage and protein conjugates, nanoparticles and polymer-\u201cruthenium-cyclopentadienyl\u201d conjugates) that can take advantage of the singularities of tumor cells (vs. healthy cells).<\/jats:p>","DOI":"10.3390\/inorganics2010096","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T12:06:20Z","timestamp":1395403580000},"page":"96-114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs"],"prefix":"10.3390","volume":"2","author":[{"given":"Andreia","family":"Valente","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias Moleculares e Materiais, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"M.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Moleculares e Materiais, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1200\/JCO.2003.03.074","article-title":"Oxaliplatin for colorectal cancer in the united states: better late than never","volume":"21","author":"Chau","year":"2003","journal-title":"J. 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