{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:45:43Z","timestamp":1762145143719,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT","doi-asserted-by":"publisher","award":["PEst C\/EQB\/LA0006\/2013","SFRH\/BPD\/74877\/2010","SFRH\/BD\/79171\/2011","FCOMP-01-0124-FEDER-037285"],"award-info":[{"award-number":["PEst C\/EQB\/LA0006\/2013","SFRH\/BPD\/74877\/2010","SFRH\/BD\/79171\/2011","FCOMP-01-0124-FEDER-037285"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGRN","award":["NORTE-07-0124-FEDER-000067\u2013Nanochemistry"],"award-info":[{"award-number":["NORTE-07-0124-FEDER-000067\u2013Nanochemistry"]}]},{"name":"COST Action","award":["CM-1203 PoCheMoN"],"award-info":[{"award-number":["CM-1203 PoCheMoN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inorganics"],"abstract":"<jats:p>A novel hybrid nanocomposite, PMo11V@N-doped few layer graphene, was prepared by a one-step protocol through direct immobilization of the tetrabutylammonium salt of a vanadium-substituted phosphomolybdate (PMo11V) onto N-doped few layer graphene (N-FLG). The nanocomposite characterization by FTIR and XPS confirmed its successful synthesis. Glassy carbon modified electrodes with PMo11V and PMo11V@N-FLG showed cyclic voltammograms consistent with surface-confined redox processes attributed to Mo-centred reductions (MoVI\u2192MoV) and a vanadium reduction (VV\u2192VIV). Furthermore, PMo11V@N-FLG modified electrodes showed good stability and well-resolved redox peaks with high current intensities. The observed enhancement of PMo11V electrochemical properties is a consequence of a strong electronic communication between the POM and  the N-doped few layer graphene. Additionally, the electro-catalytic and sensing properties towards acetaminophen (AC) and theophylline (TP) were evaluated by voltammetric techniques using a glassy carbon electrode modified with PMo11V@N-FLG. Under  the conditions used, the square wave voltammetric peak current increased linearly with AC concentration in the presence of TP, but showing two linear ranges: 1.2 \u00d7 10\u22126 to 1.2 \u00d7 10\u22124 and 1.2 \u00d7 10\u22124 to 4.8 \u00d7 10\u22124 mol dm\u22123, with different AC sensitivity values, 0.022 A\/mol dm\u22123 and 0.035 A\/mol dm\u22123, respectively (detection limit, DL = 7.5 \u00d7 10\u22127 mol dm\u22123).<\/jats:p>","DOI":"10.3390\/inorganics3020178","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T11:05:46Z","timestamp":1432119946000},"page":"178-193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomolecules Electrochemical Sensing Properties of  a PMo11V@N-Doped Few Layer Graphene Nanocomposite"],"prefix":"10.3390","volume":"3","author":[{"given":"Diana","family":"Fernandes","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal"}]},{"given":"Marta","family":"Nunes","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal"}]},{"given":"Ricardo","family":"Carvalho","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal"}]},{"given":"Revathi","family":"Bacsa","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie de Coordination UPR CNRS 8241, Composante ENSIACET,  Universit\u00e9 Toulouse, 4 all\u00e9e Emile Monso, 31030 Toulouse, France"}]},{"given":"Israel-Martyr","family":"Mbomekalle","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Physique, UMR 8000 CNRS, Universit\u00e9 Paris-Sud, 91405 Orsay Cedex, France"}]},{"given":"Philippe","family":"Serp","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie de Coordination UPR CNRS 8241, Composante ENSIACET,  Universit\u00e9 Toulouse, 4 all\u00e9e Emile Monso, 31030 Toulouse, France"}]},{"given":"Pedro","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Physique, UMR 8000 CNRS, Universit\u00e9 Paris-Sud, 91405 Orsay Cedex, France"}]},{"given":"Cristina","family":"Freire","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.measurement.2014.02.008","article-title":"Fabrication of a nanostructure-based electrochemical sensor for simultaneous determination of epinephrine and tryptophan","volume":"51","author":"Beitollahi","year":"2014","journal-title":"Measurement"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.measurement.2014.01.028","article-title":"A sensitive nanocomposite-based electrochemical sensor for voltammetric simultaneous determination of isoproterenol, acetaminophen and tryptophan","volume":"51","author":"Moazampour","year":"2014","journal-title":"Measurement"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.snb.2014.02.096","article-title":"Application of a new ferrocene-derivative modified-graphene paste electrode for simultaneous determination of isoproterenol, acetaminophen and theophylline","volume":"197","author":"Tajik","year":"2014","journal-title":"Sens. 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