{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:18:16Z","timestamp":1760235496961,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Atrial fibrillation (AF) leads to the development of cardiac remodeling\/diastolic dysfunction and vice versa. We intended to determine whether cardiac remodeling\/diastolic dysfunction is present at early stages of AF. Methods: We studied 175 patients with paroxysmal AF, compared with 175 matched control subjects, who had available echocardiography data to investigate the association between echocardiographic variables and AF from the STANISLAS cohort. Results: In this study (mean age 55 years; 70.3% male), patients with paroxysmal AF had greater left ventricular mass compared to matched controls (p &lt; 0.05). Patients with paroxysmal AF were also likely to have larger left atrial volume and a higher peak tricuspid regurgitation velocity, leading to higher prevalence (though &lt;10% in the AF group) of diastolic dysfunction (all-p &lt; 0.05). Multivariable conditional logistic regression models showed that paroxysmal AF was significantly associated with increased left ventricular mass and left atrial enlargement (all-p &lt; 0.001), but not with e\u2019 and deceleration time of E wave (all-p &gt; 0.1). Conclusions: Left ventricular mass and left atrial enlargement rather than diastolic dysfunction (as evaluated by echocardiography) were associated with paroxysmal AF irrespective of body mass index, blood pressure and renal function. These findings suggest that cardiac remodeling may occur very early in the natural history of AF.<\/jats:p>","DOI":"10.3390\/jcm10173894","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:49:51Z","timestamp":1630363791000},"page":"3894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac Remodeling and Diastolic Dysfunction in Paroxysmal Atrial Fibrillation"],"prefix":"10.3390","volume":"10","author":[{"given":"Nathalie","family":"Noirclerc","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"given":"Olivier","family":"Huttin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-6821","authenticated-orcid":false,"given":"Christian","family":"de Chillou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"given":"Christine","family":"Selton-Suty","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"given":"Laura","family":"Fillipetti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-7425","authenticated-orcid":false,"given":"Jean Marc","family":"Sellal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Nancy, 54000 Nancy, France"}]},{"given":"Erwan","family":"Bozec","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]},{"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Cardiologie & CIC-IT U 804, Centre Hospitalier Universitaire de Rennes, 35033 Rennes, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-7124","authenticated-orcid":false,"given":"Zohra","family":"Lamiral","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]},{"given":"Masatake","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]},{"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, Centre d\u2019Investigations Cliniques-1433 and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT, 54000 Nancy, France"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.3390\/ijms16023133","article-title":"Heart failure and atrial fibrillation: From basic science to clinical practice","volume":"16","author":"Ferreira","year":"2015","journal-title":"Int. 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Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.115.018614","article-title":"Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved Versus Reduced Ejection Fraction","volume":"133","author":"Santhanakrishnan","year":"2016","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1016\/j.jacc.2017.04.039","article-title":"Impact of Changes in Consensus Diagnostic Recommendations on the Echocardiographic Prevalence of Diastolic Dysfunction","volume":"69","author":"Huttin","year":"2017","journal-title":"J. Am. Coll. 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