{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:05:40Z","timestamp":1767092740670,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/04585\/2020"],"award-info":[{"award-number":["UIDB\/04585\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Dental caries is the most common non-communicable disease in children with significant aesthetic, functional, and quality of life deterioration. Depending on the depth, two approaches may be considered in primary dentition: vital pulp therapy (VPT) or non-vital therapy (NPT). This umbrella review aimed to critically assess the available systematic reviews (SRs) on VPT and NPT. An electronic database search was conducted (PubMed, Embase, Scopus, Cochrane, Web of Science, and LILACS) until June 2021. The Risk of Bias (RoB) of SRs was analyzed using the Measurement Tool to Assess SRs criteria 2 (AMSTAR2). From 272 entries, 33 SRs were included. Regarding the methodological quality, three studies were critically low, nine low, seventeen moderate, and six were rated as high quality. The quality of evidence produced by the available SRs was moderate. Future high standard SRs and well-designed clinical trials are warranted to better elucidate the clinical protocols and outcomes of VPT and NPT.<\/jats:p>","DOI":"10.3390\/jcm11010085","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T08:38:46Z","timestamp":1640335126000},"page":"85","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vital and Nonvital Pulp Therapy in Primary Dentition: An Umbrella Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-7102","authenticated-orcid":false,"given":"Lu\u00edsa Bandeira","family":"Lopes","sequence":"first","affiliation":[{"name":"Dental Pediatrics Department, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"given":"Catarina","family":"Calv\u00e3o","sequence":"additional","affiliation":[{"name":"Dental Pediatrics Department, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"given":"Filipa Salema","family":"Vieira","sequence":"additional","affiliation":[{"name":"Dental Pediatrics Department, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-9563","authenticated-orcid":false,"given":"Jo\u00e3o Albernaz","family":"Neves","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Endodontics Department, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4077","authenticated-orcid":false,"given":"Jos\u00e9 Jo\u00e3o","family":"Mendes","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Evidenced-Based Hub, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-260X","authenticated-orcid":false,"given":"Vanessa","family":"Machado","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Evidenced-Based Hub, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-8263","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"},{"name":"Evidenced-Based Hub, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Egas Moniz\u2014Cooperativa de Ensino Superior, 2829-511 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"ref_1","first-page":"256","article-title":"A Systematic Review and Meta-Analysis of Nonvital Pulp Therapy for Primary Teeth","volume":"42","author":"Coll","year":"2020","journal-title":"Pediatric Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.12688\/f1000research.16142.2","article-title":"Pulpotomy versus Pulpectomy in the Treatment of Vital Pulp Exposure in Primary Incisors. 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