{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:25:50Z","timestamp":1776468350907,"version":"3.51.2"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Tricuspid regurgitation (TR) is one of the most common heart valve diseases, associated a with poor prognosis since significant TR is associated with an increased mortality risk compared to no TR or mild regurgitation. Surgery is the standard treatment for TR, although it is associated with high morbidity, mortality, and prolonged hospitalization, particularly in tricuspid reoperation after left-sided surgery. Thus, several innovative percutaneous transcatheter approaches for repair and replacement of the tricuspid valve have gathered significant momentum and have undergone extensive clinical development in recent years, with favorable clinical outcomes in terms of mortality and rehospitalization during the first year of follow-up. We present three clinical cases of transcatheter tricuspid valve replacement in an orthotopic position with two different innovative systems along with a review of the state-of-the-art of this emergent topic.<\/jats:p>","DOI":"10.3390\/jcm12041371","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:37:07Z","timestamp":1675906627000},"page":"1371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transcatheter Tricuspid Valve Replacement: Illustrative Case Reports and Review of State-of-Art"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-2935","authenticated-orcid":false,"given":"Manuel","family":"Barreiro-P\u00e9rez","sequence":"first","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Roc\u00edo","family":"Gonz\u00e1lez-Ferreiro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Berenice","family":"Caneiro-Queija","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Marta","family":"Tavares-Silva","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-3449","authenticated-orcid":false,"given":"Luis","family":"Puga","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Jose","family":"Parada-Barcia","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-3440","authenticated-orcid":false,"given":"Alvaro","family":"Rodriguez-Perez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Jose","family":"Baz-Alonso","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Miguel","family":"Pinon-Esteban","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Rodrigo","family":"Estevez-Loureiro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]},{"given":"Andres","family":"Iniguez-Romo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Galicia Sur Health Research Institute (IISGS), University Hospital Alvaro Cunqueiro, 36213 Vigo, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jcmg.2018.06.014","article-title":"Burden of Tricuspid Regurgitation in Patients Diagnosed in the Community Setting","volume":"12","author":"Topilsky","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/eurheartj\/ehy641","article-title":"Tricuspid regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure: A systematic review and meta-analysis","volume":"40","author":"Wang","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/j.jacc.2019.09.028","article-title":"Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation","volume":"74","author":"Taramasso","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.15420\/icr.2021.09","article-title":"Patient-specific Computer Simulation: An Emerging Technology for Guiding the Transcatheter Treatment of Patients with Bicuspid Aortic Valve","volume":"16","author":"Dowling","year":"2021","journal-title":"Interv. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11517-020-02138-4","article-title":"Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve","volume":"58","author":"Pasta","year":"2020","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/j.jcin.2020.05.032","article-title":"2-Year Follow-Up After Transseptal Transcatheter Mitral Valve Replacement With the Cardiovalve","volume":"13","author":"Maisano","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2217\/fca-2020-0181","article-title":"Transcatheter tricuspid valve implantation with the Cardiovalve system","volume":"17","author":"Aoi","year":"2021","journal-title":"Future Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4244\/EIJ-D-21-00695","article-title":"Transcatheter treatment for tricuspid valve disease","volume":"17","author":"Praz","year":"2021","journal-title":"EuroIntervention"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.echo.2018.07.007","article-title":"Comparison between Three-Dimensional Echocardiography and Computed Tomography for Comprehensive Tricuspid Annulus and Valve Assessment in Severe Tricuspid Regurgitation: Implications for Tricuspid Regurgitation Grading and Transcatheter Therapies","volume":"31","author":"Praz","year":"2018","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jcin.2020.03.026","article-title":"First-in-Man Experience of Transcatheter Tricuspid Valve Replacement With LuX-Valve in High-Risk Tricuspid Regurgitation Patients","volume":"13","author":"Lu","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.4244\/EIJ-D-21-00095","article-title":"Twelve-month outcomes of the LuX-Valve for transcatheter treatment of severe tricuspid regurgitation","volume":"17","author":"Sun","year":"2021","journal-title":"EuroIntervention"},{"key":"ref_12","first-page":"455","article-title":"Safety and efficacy of transcatheter tricuspid valve replacement with LuX-Valve in patients with severe tricuspid regurgitation","volume":"49","author":"Ning","year":"2021","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1088","DOI":"10.4244\/EIJ-D-22-00517","article-title":"A first-in-human study of transjugular transcatheter tricuspid valve replacement with the LuX-Valve Plus system","volume":"18","author":"Zhang","year":"2022","journal-title":"EuroIntervention"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e005840","DOI":"10.1161\/CIRCINTERVENTIONS.117.005840","article-title":"First-in-Human Implantations of the NaviGate Bioprosthesis in a Severely Dilated Tricuspid Annulus and in a Failed Tricuspid Annuloplasty Ring","volume":"10","author":"Navia","year":"2017","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1016\/j.jcin.2020.07.008","article-title":"Early Multinational Experience of Transcatheter Tricuspid Valve Replacement for Treating Severe Tricuspid Regurgitation","volume":"13","author":"Hahn","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1370.e5","DOI":"10.1016\/j.cjca.2018.07.481","article-title":"Transcatheter Tricuspid Valve Replacement for Treating Severe Tricuspid Regurgitation: Initial Experience with the NaviGate Bioprosthesis","volume":"34","author":"Asmarats","year":"2018","journal-title":"Can. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Caneiro-Queija, B., Est\u00e9vez-Loureiro, R., Pi\u00f1\u00f3n-Esteban, M., Barreiro-P\u00e9rez, M., Baz-Alonso, J.A., and \u00cd\u00f1iguez-Romo, A. (2022). Transfemoral transcatheter tricuspid valve replacement with the Cardiovalve system. Rev. Esp. Cardiol., in press.","DOI":"10.1016\/j.rec.2022.08.011"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.jcin.2022.06.023","article-title":"Cardiovalve Transfemoral Tricuspid Valve Replacement Assisted With CT-Fluoroscopy Fusion Imaging","volume":"15","author":"Baz","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.jcin.2020.06.040","article-title":"Transcatheter Mitral Valve Replacement with the Transseptal EVOQUE System","volume":"13","author":"Webb","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jcin.2022.01.280","article-title":"Transcatheter Tricuspid Valve Replacement with the EVOQUE System: 1-Year Outcomes of a Multicenter, First-in-Human Experience","volume":"15","author":"Webb","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_21","first-page":"287","article-title":"Transcatheter Mitral Valve Replacement with Intrepid","volume":"8","author":"McCarthy","year":"2019","journal-title":"Interv. Cardiol. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jcin.2020.11.045","article-title":"Transfemoral Transcatheter Tricuspid Valve Replacement With the EVOQUE System: A Multicenter, Observational, First-in-Human Experience","volume":"14","author":"Fam","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.jaccas.2021.06.014","article-title":"First-in-Human Percutaneous Transcatheter Tricuspid Valve Replacement with a Novel Valve","volume":"3","author":"Vaturi","year":"2021","journal-title":"JACC Case Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"862","DOI":"10.4244\/EIJ-D-22-00277","article-title":"First-in-human implantation of the Topaz transcatheter tricuspid valve replacement system","volume":"18","author":"Teiger","year":"2022","journal-title":"EuroIntervention"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jcin.2022.01.016","article-title":"Transfemoral Tricuspid Valve Replacement in Patients with Tricuspid Regurgitation: TRISCEND Study 30-Day Results","volume":"15","author":"Kodali","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1019813","DOI":"10.3389\/fcvm.2022.1019813","article-title":"Safety, efficacy, and clinical outcomes of transcatheter tricuspid valve replacement: One-year follow-up","volume":"9","author":"Mao","year":"2022","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1371\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:27:50Z","timestamp":1760120870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/4\/1371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jcm12041371"],"URL":"https:\/\/doi.org\/10.3390\/jcm12041371","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]}}}