{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:28:25Z","timestamp":1763767705573,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endoscopic submucosal dissection (ESD) in colorectal lesions is demanding, and a significant rate of non-curative procedures is expected. We aimed to assess the rate of residual lesion after a piecemeal ESD resection, or after an en bloc resection but with positive horizontal margins (local-risk resection\u2014LocRR), for colorectal benign neoplasia. A retrospective multicenter analysis of consecutive colorectal ESDs was performed. Patients with LocRR ESDs for the treatment of benign colorectal lesions with at least one follow-up endoscopy were included. A cohort of en bloc resected lesions, with negative margins, was used as the control. A total of 2255 colorectal ESDs were reviewed; 352 of the ESDs were \u201cnon-curative\u201d. Among them, 209 were LocRR: 133 high-grade dysplasia and 76 low-grade dysplasia. Ten cases were excluded due to missing data. A total of 146 consecutive curative resections were retrieved for comparison. Compared to the \u201ccurative group\u201d, LocRRs were observed in lengthier procedures, with larger lesions, and in non-granular LSTs. Recurrence was higher in the LocRR group (16\/199, 8% vs. 1\/146, 0.7%; p = 0.002). However, statistical significance was lost when considering only en bloc resections with positive horizontal margins (p = 0.068). In conclusion, a higher rate of residual lesion was found after a piecemeal ESD resection, but not after an en bloc resection with positive horizontal margins.<\/jats:p>","DOI":"10.3390\/jcm12165356","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:47:02Z","timestamp":1692269222000},"page":"5356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0576","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Santos-Antunes","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, 4200-319 Porto, Portugal"},{"name":"Ipatimup\/i3S (Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto), 4200-135 Porto, Portugal"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Edouard Herriot Hospital, 69003 Lyon, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-1231","authenticated-orcid":false,"given":"Felipe","family":"Ramos-Zabala","sequence":"additional","affiliation":[{"name":"Servicio de Gastroenterolog\u00eda, Departamento de Ciencias M\u00e9dicas Cl\u00ednicas, Hospital Universitario HM Montepr\u00edncipe, HM Hospitales, 28660 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-5952","authenticated-orcid":false,"given":"Paolo","family":"Cecinato","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL\u2014IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}]},{"given":"Francisco","family":"Gallego","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Poniente, 04700 Almer\u00eda, Spain"}]},{"given":"Pedro","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar Lisboa Ocidental EPE, 1169-050 Lisbon, Portugal"},{"name":"Lisbon Advanced Endoscopic Center, Hospital Lus\u00edadas, 2724-002 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-6569","authenticated-orcid":false,"given":"Andr\u00e9","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar Lisboa Ocidental EPE, 1169-050 Lisbon, Portugal"}]},{"given":"Sandro","family":"Sferrazza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, 38123 Trento, Italy"}]},{"given":"Frieder","family":"Berr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}]},{"given":"Andrej","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria"}]},{"given":"Arnaud","family":"Lemmers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}]},{"given":"Mariana Figueiredo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), 1000 Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-3746","authenticated-orcid":false,"given":"Eduardo","family":"Alb\u00e9niz","sequence":"additional","affiliation":[{"name":"Complejo Hospitalario de Navarra, Navarrabiomed Research Institute, Public University of Navarra, IdiSNA, 31006 Pamplona, Spain"}]},{"given":"Hugo","family":"Uchima","sequence":"additional","affiliation":[{"name":"Servicio de Endoscopia Digestiva Centro M\u00e9dico Teknon, 08022 Barcelona, Spain"},{"name":"Servicio de Gastroenterolog\u00eda Hospital Universitario Germans Trias i Pujol, 08916 Barcelona, Spain"}]},{"given":"Ricardo","family":"K\u00fcttner-Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, 4099-001 Porto, Portugal"}]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, 4400-129 Vila Nova de Gaia, Portugal"}]},{"given":"Rui","family":"Morais","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-8304","authenticated-orcid":false,"given":"Sunil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney 2145, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-6364","authenticated-orcid":false,"given":"Daniel","family":"Martinho-Dias","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Information and Decision in Health, Faculty of Medicine, University of Porto, 4169-007 Porto, Portugal"}]},{"given":"Isabel","family":"Faria-Ramos","sequence":"additional","affiliation":[{"name":"Ipatimup\/i3S (Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto), 4200-135 Porto, Portugal"}]},{"given":"Margarida","family":"Marques","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"given":"Michael J.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney 2145, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-9872","authenticated-orcid":false,"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.gie.2017.02.024","article-title":"Clinical outcomes after endoscopic submucosal dissection for colorectal neoplasia: A systematic review and meta-analysis","volume":"86","author":"Fuccio","year":"2017","journal-title":"Gastrointest. 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