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(PIDDAC)","award":["LA\/P\/0006\/2020"],"award-info":[{"award-number":["LA\/P\/0006\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>L-Carnitine, a natural antioxidant found in mammals, plays a crucial role in the transport of long-chain fatty acids across the inner mitochondrial membrane. It is used as a nutritional supplement by professional athletes, improving performance and post-exercise recovery. Additionally, its therapeutic applications, including those in male infertility, have been investigated, as it may act as a defense mechanism against the excessive production of reactive oxygen species (ROS) in the testis, a process that can lead to sperm damage. This effect is achieved by enhancing the expression and activity of enzymes with antioxidant properties. Nevertheless, the mechanisms underlying the benefits of L-Carnitine remain unknown. This review aims to consolidate the current knowledge about the potential benefits of L-Carnitine and its role in male (in)fertility. Considering in vitro studies with Sertoli cells, pre-clinical studies, and investigations involving infertile men, a comprehensive understanding of the effects of L-Carnitine has been established. In vitro studies suggest that L-Carnitine has a direct influence on somatic Sertoli cells, improving the development of germ cells. Overall, evidence supports that L-Carnitine can positively impact male fertility, even at a relatively low dose of 2 g\/day. This supplementation enhances sperm parameters, regulates hormone levels, reduces ROS levels, and subsequently improves fertility rates. However, further research is needed to elucidate the underlying mechanisms and establish optimal doses. In conclusion, the role of L-Carnitine in the field of male reproductive health is highlighted, with the potential to improve sperm quality and fertility.<\/jats:p>","DOI":"10.3390\/jcm12185796","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:23:42Z","timestamp":1693995822000},"page":"5796","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["L-Carnitine and Male Fertility: Is Supplementation Beneficial?"],"prefix":"10.3390","volume":"12","author":[{"given":"Filipa G.","family":"Mateus","sequence":"first","affiliation":[{"name":"Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-4486","authenticated-orcid":false,"given":"Silvia","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-9596","authenticated-orcid":false,"given":"Ana D.","family":"Martins","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-783X","authenticated-orcid":false,"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"iBiMED-Institute of Biomedicine, Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7869","authenticated-orcid":false,"given":"Maria de Lourdes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, December 09). Infertility. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/infertility."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/IJGM.S241099","article-title":"Some of the Factors Involved in Male Infertility: A Prospective Review","volume":"13","author":"Babakhanzadeh","year":"2020","journal-title":"Int. J. Gen. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.2047-2927.2013.00107.x","article-title":"Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: A meta-analysis","volume":"1","author":"Chua","year":"2013","journal-title":"Andrology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1210\/clinem\/dgaa781","article-title":"Male infertility due to testicular disorders","volume":"106","author":"Sharma","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","unstructured":"Gilbert, S.F. (2023, July 07). Spermatogenesis, Developmental Biology, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10095\/."},{"key":"ref_6","unstructured":"Cole, L.A. (2018). Human Male Spermatogenesis in Encyclopedia of Reproduction, Academic Press. [2nd ed.]. Biology of Life."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrurol.2012.77","article-title":"Metabolic regulation is important for spermatogenesis","volume":"9","author":"Rato","year":"2012","journal-title":"Nat. Rev. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/abbi.2000.1880","article-title":"Mammalian Sperm Acrosome: Formation, Contents, and Function","volume":"379","author":"Tulsiani","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1098\/rstb.2010.0024","article-title":"The biology of spermatogenesis: The past, present and future","volume":"365","author":"Cheng","year":"2010","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/dmn004","article-title":"Oxidative stress and male infertility\u2014A clinical perspective","volume":"14","author":"Tremellen","year":"2008","journal-title":"Hum. Reprod. Updat."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Martin-Hidalgo, D., Bragado, M.J., Batista, A.R., Oliveira, P.F., and Alves, M.G. (2019). Antioxidants and Male Fertility: From Molecular Studies to Clinical Evidence. Antioxidants, 8.","DOI":"10.3390\/antiox8040089"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.rbmo.2014.02.004","article-title":"Sperm DNA damage caused by oxidative stress: Modifiable clinical, lifestyle and nutritional factors in male infertility","volume":"28","author":"Wright","year":"2014","journal-title":"Reprod. Biomed. Online"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0891-5849(02)00793-1","article-title":"Causes and consequences of oxidative stress in Alzheimer\u2019s disease","volume":"32","author":"Smith","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.nu.16.070196.000341","article-title":"Antioxidants in human health and disease","volume":"16","author":"Halliwell","year":"1996","journal-title":"Annu. Rev. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.yjmcc.2014.01.018","article-title":"An overview of mechanisms of redox signaling","volume":"73","author":"Forman","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1530\/ror.0.0040031","article-title":"Origin of DNA damage in ejaculated human spermatozoa","volume":"4","author":"Sakkas","year":"1999","journal-title":"Rev. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dutta, S., Sengupta, P., Slama, P., and Roychoudhury, S. (2021). Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810043"},{"key":"ref_18","first-page":"525","article-title":"Oxidative Stress Induced Sperm DNA Damage, a Possible Reason for Male Infertility","volume":"13","author":"Hosen","year":"2015","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2605.1998.00106.x","article-title":"Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: Relationships with semen quality and sperm function","volume":"21","author":"Gomez","year":"1998","journal-title":"Int. J. Androl."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cilio, S., Rienzo, M., Villano, G., Mirto, B.F., Giampaglia, G., Capone, F., Ferretti, G., Di Zazzo, E., and Crocetto, F. (2022). Beneficial Effects of Antioxidants in Male Infertility Management: A Narrative Review. Oxygen, 2.","DOI":"10.3390\/oxygen2010001"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12288-015-0569-3","article-title":"l-carnitine as a Potential Additive in Blood Storage Solutions: A Study on Erythrocytes","volume":"32","author":"Soumya","year":"2016","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.29252\/ijrm.14.12.729","article-title":"Antioxidant supplements and semen parameters: An evidence based review","volume":"14","author":"Ahmadi","year":"2016","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.18565\/urology.2019.4.61-68","article-title":"Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin\u00ae forte) for treatment of male infertility","volume":"2019","author":"Gamidov","year":"2019","journal-title":"Urologiia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","article-title":"Carnitine transport and fatty acid oxidation","volume":"1863","author":"Longo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/138920011796504536","article-title":"L-Carnitine\u2014Metabolic Functions and Meaning in Humans Life","volume":"12","author":"Pekala","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.nut.2004.04.003","article-title":"Supplementation of L-Carnitine in athletes: Does it make sense?","volume":"20","author":"Karlic","year":"2004","journal-title":"Nutrition"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/iub.1646","article-title":"Significance of L-Carnitine for Human Health","volume":"69","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.fertnstert.2003.10.034","article-title":"A placebo-controlled double-blind randomized trial of the use of combined L-Carnitine and L-acetyl-carnitine treatment in men with asthenozoospermia","volume":"81","author":"Lenzi","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/2.2.87","article-title":"Role of free L-Carnitine and acetyl-L-Carnitine in post-gonadal maturation of mammalian spermatozoa","volume":"2","author":"Jeulin","year":"1996","journal-title":"Hum. Reprod. Update"},{"key":"ref_30","first-page":"26","article-title":"Seminal L-Carnitine In Infertile Oligoasthenoteratozoospermic Men with Varicocele","volume":"23","author":"Mostafa","year":"2022","journal-title":"J. Reprod. Infertil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0015-0282(16)41589-X","article-title":"Epididymis and seminal vesicle as sources of carnitine in human seminal fluid: The clinical significance of the carnitine concentration in human seminal fluid","volume":"27","author":"Lewin","year":"1976","journal-title":"Fertil. Steril."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0015-0282(16)48024-6","article-title":"Free L-Carnitine in human semen: Its variability in different andrologic pathologies","volume":"42","author":"Canale","year":"1984","journal-title":"Fertil. Steril."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s12011-019-02016-7","article-title":"Selenium and L-Carnitine Ameliorate Reproductive Toxicity Induced by Cadmium in Male Mice","volume":"197","author":"Alharthi","year":"2020","journal-title":"Biol. Trace Element Res."},{"key":"ref_34","first-page":"77","article-title":"Effects of L-Carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality","volume":"10","author":"Aliabadi","year":"2012","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/andr.12426","article-title":"Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin-treated rats","volume":"6","author":"Cabral","year":"2018","journal-title":"Andrology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10522-008-9159-1","article-title":"L-Carnitine mediates protection against DNA damage in lymphocytes of aged rats","volume":"10","author":"Thangasamy","year":"2009","journal-title":"Biogerontology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.3382\/ps\/pez201","article-title":"The capability of L-Carnitine-mediated antioxidant on cock during aging: Evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1\/2","volume":"98","author":"Elokil","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/bcpt.12679","article-title":"The Effects of L-Carnitine against Cyclophosphamide-Induced Injuries in Mouse Testis","volume":"120","author":"Cao","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_39","first-page":"4698","article-title":"Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: A randomized controlled trial","volume":"26","author":"Ma","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_40","first-page":"420","article-title":"L-Carnitine: Safe and effective for asthenozoospermia","volume":"16","author":"Wang","year":"2010","journal-title":"Zhonghua Nan Ke Xue = Natl. J. Androl."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1111\/andr.12805","article-title":"Dietary supplementation with a novel L-Carnitine multi-micronutrient in idiopathic male subfertility involving oligo-, astheno-, teratozoospermia: A randomized clinical study","volume":"8","author":"Kopets","year":"2020","journal-title":"Andrology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5534\/wjmh.2014.32.1.1","article-title":"Effect of Oxidative Stress on Male Reproduction","volume":"32","author":"Agarwal","year":"2014","journal-title":"World J. Men\u2019s Health"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fielding, R., Riede, L., Lugo, J.P., and Bellamine, A. (2018). l-Carnitine Supplementation in Recovery after Exercise. Nutrients, 10.","DOI":"10.3390\/nu10030349"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/mus.880140703","article-title":"Carnitine in muscle, serum, and urine of nonprofessional athletes: Effects of physical exercise, training, and L-Carnitine administration","volume":"14","author":"Arenas","year":"1991","journal-title":"Muscle Nerve"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1123\/ijsnem.18.6.567","article-title":"Carbohydrate, protein, and fat metabolism during exercise after oral carnitine supplementation in humans","volume":"18","author":"Broad","year":"2008","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_46","first-page":"129","article-title":"Studies concerning the ergogenic value of Cantamega-2000\u00ae supply in top junior cyclists","volume":"25","author":"Dragan","year":"1988","journal-title":"Physiologie"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1055\/s-2007-972854","article-title":"Effects of prolonged L-Carnitine administration on delayed muscle pain and CK release after eccentric effort","volume":"17","author":"Giamberardino","year":"1996","journal-title":"Int. J. Sports Med."},{"key":"ref_48","first-page":"111","article-title":"Studies concerning chronic and acute effects of L-Carnitina in elite athletes","volume":"26","author":"Vasiliu","year":"1989","journal-title":"Rev. Roum. Morphol. Physiol.-Ser. Physiol."},{"key":"ref_49","first-page":"123","article-title":"The effect of two-week L-Carnitine supplementation on exercise\u2014Induced oxidative stress and muscle damage","volume":"5","author":"Parandak","year":"2014","journal-title":"Asian J. Sports Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2165\/00002512-200320100-00004","article-title":"Levocarnitine administration in elderly subjects with rapid muscle fatigue: Effect on body composition, lipid profile and fatigue","volume":"20","author":"Pistone","year":"2003","journal-title":"Drugs Aging"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system: From concept to molecular analysis","volume":"244","author":"McGarry","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20023","DOI":"10.1074\/jbc.R115.663260","article-title":"Physiological consequences of compartmentalized acyl-CoA metabolism","volume":"290","author":"Cooper","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30087","article-title":"Disorders of carnitine transport and the carnitine cycle","volume":"142C","author":"Longo","year":"2006","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.mam.2012.07.010","article-title":"SLC27 fatty acid transport proteins","volume":"34","author":"Anderson","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12291-014-0437-1","article-title":"Effect of L-Carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction","volume":"30","author":"Jain","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1203\/01.PDR.0000057988.62605.13","article-title":"Effect of L-Carnitine supplementation on cardiac carnitine palmitoyltransferase activities and plasma carnitine concentrations in adriamycin-treated rats","volume":"53","author":"Yoon","year":"2003","journal-title":"Pediatr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.2002.tb04278.x","article-title":"Regulation of fat metabolism in skeletal muscle","volume":"967","author":"Jeukendrup","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_58","unstructured":"The Role of Carnitine in Enhancing Physical Performance, and Marriott, B.M. (2023, March 30). Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK209052\/."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-4165(90)90147-O","article-title":"Metabolic changes induced by maximal exercise in human subjects following L-Carnitine administration","volume":"1034","author":"Siliprandi","year":"1990","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.12997\/jla.2020.9.3.313","article-title":"Mitochondrial Fatty Acid Oxidation Disorders: Laboratory Diagnosis, Pathogenesis, and the Complicated Route to Treatment","volume":"9","author":"Wanders","year":"2020","journal-title":"J. Lipid Atheroscler."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Virmani, M.A., and Cirulli, M. (2022). The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052717"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.mam.2004.06.003","article-title":"Role of carnitine esters in brain neuropathology","volume":"25","author":"Virmani","year":"2004","journal-title":"Mol. Asp. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0167-4889(85)90153-3","article-title":"Protection by acyl-carnitines and phenylmethylsulfonyl fluoride of rat heart subjected to ischemia and reperfusion","volume":"847","author":"Dubelaar","year":"1985","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Cell Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"C802","DOI":"10.1152\/ajpcell.00046.2002","article-title":"L-Carnitine: A potential treatment for blocking apoptosis and preventing skeletal muscle myopathy in heart failure","volume":"283","author":"Vescovo","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2017.02.007","article-title":"Acetyl-L-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson\u2019s disease in the rat","volume":"89","author":"Bashiri","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.fertnstert.2007.11.067","article-title":"L-Carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos","volume":"91","author":"Abdelrazik","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_67","first-page":"529","article-title":"The role of apoptosis and protective effect of carnitine in contralateral testicular injury in experimental unilateral testicular torsion","volume":"15","author":"Cankorkmaz","year":"2009","journal-title":"Turk. J. Trauma Emerg. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/88815","article-title":"Mouse models of cell death","volume":"28","author":"Ranger","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5653\/cerm.2019.03440","article-title":"Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax","volume":"47","author":"Vardiyan","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/cpr.12080","article-title":"Protective effect of acetyl-l-carnitine against cisplatin ototoxicity: Role of apoptosis-related genes and pro-inflammatory cytokines","volume":"47","author":"Altun","year":"2014","journal-title":"Cell Prolif."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-5793(00)01817-2","article-title":"Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine","volume":"478","author":"Mutomba","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopha.2014.12.030","article-title":"Role of NF-E2-related factor 2 in neuroprotective effect of L-Carnitine against high glucose-induced oxidative stress in the retinal ganglion cells","volume":"69","author":"Cao","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI77632","article-title":"Sirtuin 3\u2013dependent mitochondrial dynamic improvements protect against acute kidney injury","volume":"125","author":"Morigi","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.119.315767","article-title":"Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress","volume":"126","author":"Dikalova","year":"2020","journal-title":"Circ. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110928","DOI":"10.1016\/j.biopha.2020.110928","article-title":"Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson\u2019s disease","volume":"132","author":"Shen","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"105432","DOI":"10.1016\/j.phrs.2021.105432","article-title":"SIRT3 as a potential therapeutic target for heart failure","volume":"165","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.fsi.2019.08.041","article-title":"L-Carnitine regulated Nrf2\/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-\u03baB signaling pathway in Rhynchocypris lagowski Dybowski","volume":"93","author":"Zhang","year":"2019","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/19396368.2021.1972359","article-title":"Relationship between functional Nrf2 gene promoter polymorphism and sperm DNA damage in male infertility","volume":"67","author":"Aydos","year":"2021","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2022.10.314","article-title":"Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice","volume":"193","author":"Han","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lfs.2017.12.015","article-title":"L-Carnitine and heart disease","volume":"194","author":"Wang","year":"2018","journal-title":"Life Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s11064-017-2288-7","article-title":"L-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain","volume":"42","author":"Ferreira","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1155\/S0962935193000742","article-title":"Regulation of normal human polyrnorphonuclear leucocytes by carnitine","volume":"2","author":"Fattorossi","year":"1993","journal-title":"Mediat. Inflamm."},{"key":"ref_85","first-page":"236","article-title":"L-Carnitine levels in the seminal plasma of fertile and infertile men: Correlation with sperm quality","volume":"45","author":"Matalliotakis","year":"2000","journal-title":"Int. J. Fertil. Women\u2019s Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/humrep\/16.11.2338","article-title":"Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis","volume":"16","author":"Vicari","year":"2001","journal-title":"Hum. Reprod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0005-2760(72)90134-8","article-title":"The distribution of carnitine in male reproductive tissues and its effect on palmitate oxidation by spermatozoal particles","volume":"280","author":"Casillas","year":"1972","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Lipids Lipid Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/jrf.0.0560439","article-title":"The distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation","volume":"56","author":"Casillas","year":"1979","journal-title":"Reproduction"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/jrf.0.0610059","article-title":"Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis","volume":"61","author":"Hinton","year":"1981","journal-title":"J. Reprod. Fertil."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-2007-978596","article-title":"Metabolic effects of L-Carnitine on prepubertal rat Sertoli cells","volume":"32","author":"Palmero","year":"2000","journal-title":"Horm. Metab. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-2004-814451","article-title":"Effects of Carnitines on Rat Sertoli Cell Protein Metabolism","volume":"36","author":"Caviglia","year":"2004","journal-title":"Horm. Metab. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1530\/rep.1.00507","article-title":"OCTN2-mediated transport of carnitine in isolated Sertoli cells","volume":"129","author":"Kobayashi","year":"2005","journal-title":"Reproduction"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s11356-017-0624-8","article-title":"Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: Ameliorative potentials of L-Carnitine","volume":"25","author":"Khushboo","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"124","DOI":"10.25122\/jml-2021-0213","article-title":"L-Carnitine effect on induced hyperlipidemia on premature rats: Fertility profile","volume":"15","author":"Karam","year":"2022","journal-title":"J. Med. Life"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/vms3.473","article-title":"Ameliorative effect of L-Carnitine on chronic lead-induced reproductive toxicity in male rats","volume":"7","author":"Ahmed","year":"2021","journal-title":"Vet. Med. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.theriogenology.2016.09.031","article-title":"Carnitine supplementation decreases capacitation-like changes of frozen-thawed buffalo spermatozoa","volume":"88","author":"Longobardi","year":"2017","journal-title":"Theriogenology"},{"key":"ref_97","first-page":"1059","article-title":"L-Carnitine protects the motion parameters and mitochondrial function of human sperm in cryopreservation","volume":"24","author":"Fu","year":"2018","journal-title":"Zhonghua Nan Ke Xue = Natl. J. Androl."},{"key":"ref_98","first-page":"e12806","article-title":"Protective effect of L-Carnitine and L-Arginine against busulfan-induced oligospermia in adult rat","volume":"50","year":"2017","journal-title":"Andrologia"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10815-005-7204-4","article-title":"The effects of L-Carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities","volume":"22","author":"Khademi","year":"2005","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_100","first-page":"1064","article-title":"L-Carnitine improves sperm acrosin activity in male infertility patients","volume":"24","author":"Sun","year":"2018","journal-title":"Zhonghua Nan Ke Xue = Natl. J. Androl."},{"key":"ref_101","first-page":"330","article-title":"The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, before and after Freezing in Oligospermia Men","volume":"18","author":"Nezhad","year":"2021","journal-title":"Urol. J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e12927","DOI":"10.1111\/and.12927","article-title":"Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study","volume":"50","author":"Busetto","year":"2018","journal-title":"Andrologia"},{"key":"ref_103","unstructured":"Shils, M.E., Olson, J.A., Shike, M., and Ross, A.C. (1999). Modern Nutrition in Health and Disease, Lippincott Williams & Wilkins. [9th ed.]."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"ix","DOI":"10.1196\/annals.1320.019","article-title":"Carnitine: Lessons from one hundred years of research","volume":"1033","author":"Alesci","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e13155","DOI":"10.1111\/aji.13155","article-title":"In vitro antioxidation effect of Quercetin on sperm function from the infertile patients with leukocytospermia","volume":"82","author":"Diao","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Pasquariello, R., Verdile, N., Brevini, T.A.L., Gandolfi, F., Boiti, C., Zerani, M., and Maranesi, M. (2020). The Role of Resveratrol in Mammalian Reproduction. Molecules, 25.","DOI":"10.20944\/preprints202009.0003.v1"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e13267","DOI":"10.1111\/and.13267","article-title":"Double-blind, randomised, placebo-controlled trial on the effect of L-Carnitine and L-Acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia","volume":"51","author":"Micic","year":"2019","journal-title":"Andrologia"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/18\/5796\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:45:53Z","timestamp":1760129153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/18\/5796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":107,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jcm12185796"],"URL":"https:\/\/doi.org\/10.3390\/jcm12185796","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}