{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T20:58:07Z","timestamp":1775941087684,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA18216"],"award-info":[{"award-number":["CA18216"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with adverse CV outcomes. Vascular aging (VA), which is defined as the progressive deterioration of arterial function and structure over a lifetime, is an independent predictor of both AF development and CV events. A timing identification and treatment of early VA has therefore the potential to reduce the risk of AF incidence and related CV events. A network of scientists and clinicians from the COST Action VascAgeNet identified five clinically and methodologically relevant questions regarding the relationship between AF and VA and conducted a narrative review of the literature to find potential answers. These are: (1) Are VA biomarkers associated with AF? (2) Does early VA predict AF occurrence better than chronological aging? (3) Is early VA a risk enhancer for the occurrence of CV events in AF patients? (4) Are devices measuring VA suitable to perform subclinical AF detection? (5) Does atrial-fibrillation-related rhythm irregularity have a negative impact on the measurement of vascular age? Results showed that VA is a powerful and independent predictor of AF incidence, however, its role as risk modifier for the occurrence of CV events in patients with AF is debatable. Limited and inconclusive data exist regarding the reliability of VA measurement in the presence of rhythm irregularities associated with AF. To date, no device is equipped with tools capable of detecting AF during VA measurements. This represents a missed opportunity to effectively perform CV prevention in people at high risk. Further advances are needed to fill knowledge gaps in this field.<\/jats:p>","DOI":"10.3390\/jcm13051207","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:50:07Z","timestamp":1708429807000},"page":"1207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions\u2014A Review from the VascAgeNet COST Action"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0180-859X","authenticated-orcid":false,"given":"Giacomo","family":"Pucci","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, Santa Maria University Hospital, 05100 Terni, Italy"},{"name":"Department of Medicine and Surgery, University of Perugia, 06125 Perugia, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-4991","authenticated-orcid":false,"given":"Andrea","family":"Grillo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-4398","authenticated-orcid":false,"given":"Kalliopi V.","family":"Dalakleidi","sequence":"additional","affiliation":[{"name":"Biomedical Simulations and Imaging (BIOSIM) Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-5067","authenticated-orcid":false,"given":"Emil","family":"Fraenkel","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Faculty of General Medicine, Pavol Jozef \u0160af\u00e1rik University, 04011 Ko\u0161ice, Slovakia"}]},{"given":"Eugenia","family":"Gkaliagkousi","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 54124 Thessaloniki, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-7660","authenticated-orcid":false,"given":"Spyretta","family":"Golemati","sequence":"additional","affiliation":[{"name":"Medical School, National and Kapodistrian University of Athens, 10675 Athens, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-8164","authenticated-orcid":false,"given":"Andrea","family":"Guala","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebr\u00f3n Research Institute (VHIR), 08035 Barcelona, Spain"},{"name":"CIBER CV, Instituto de Salud Carlos III, 28029 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-1019","authenticated-orcid":false,"given":"Bernhard","family":"Hametner","sequence":"additional","affiliation":[{"name":"AIT Austrian Institute of Technology, Center for Health & Bioresources, Medical Signal Analysis, 1210 Vienna, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7205-4644","authenticated-orcid":false,"given":"Antonios","family":"Lazaridis","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 54124 Thessaloniki, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-5481","authenticated-orcid":false,"given":"Christopher C.","family":"Mayer","sequence":"additional","affiliation":[{"name":"AIT Austrian Institute of Technology, Center for Health & Bioresources, Medical Signal Analysis, 1210 Vienna, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-7698","authenticated-orcid":false,"given":"Ioana","family":"Mozos","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences\u2014Pathophysiology, Center for Translational Research and Systems Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300173 Timisoara, Romania"}]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"H&TRC\u2014Health & Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, 3000-331 Coimbra, Portugal"},{"name":"Laboratory for Applied Research in Health (Labinsa\u00fade), Polytechnic University of Coimbra, 3000-331 Coimbra, Portugal"}]},{"given":"Dave","family":"Veerasingam","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Galway University Hospitals, H91 YR71 Galway, Ireland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-8263","authenticated-orcid":false,"given":"Dimitrios","family":"Terentes-Printzios","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-7133","authenticated-orcid":false,"given":"Davide","family":"Agnoletti","sequence":"additional","affiliation":[{"name":"Cardiovascular Internal Medicine, IRCCS Azienda Ospedaliero\u2014Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Cardiovascular Internal Medicine, Medical and Surgical Sciences Department, University of Bologna, 40138 Bologna, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1747493019897870","article-title":"Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge","volume":"16","author":"Lippi","year":"2020","journal-title":"Int. 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