{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:40:50Z","timestamp":1772764850900,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: This study investigates the mediating role of moderate physical activity (MPA), vigorous physical activity (VPA), and self-rated health (SRH) in the association between depression and quality of life (QoL) in a large sample of Europeans aged 50 and over, differentiated by sex. Methods: Data from the 2017 Survey of Health, Ageing and Retirement in Europe were analyzed, including 11,986 individuals (6843 women) aged 50 and older. All information was collected through face-to-face interviews: sociodemographic data, SRH, physical activity levels, depression (EURO-D scale), and QoL (CASP-12). Results: Comparatively, women reported a higher prevalence of depression, a lower perception of QoL, and slightly lower levels of SRH, MPA, and VPA. Parallel mediation models revealed, for both sexes, that an increase in VPA levels was more effective in benefiting SRH; and MPA proved to be a better promoter of QoL. When comparing sexes, only the path depression \u2192 VPA \u2192 QoL showed a significant difference (p &lt; 0.001). Conclusions: These results provide valuable insights for developing physical activity interventions capable of improving mental health and promoting QoL in older European adults.<\/jats:p>","DOI":"10.3390\/jcm13226760","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:34:11Z","timestamp":1731324851000},"page":"6760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Mediating Role of Physical Activity and Self-Rated Health in the Association Between Depression and Quality of Life in Older Europeans: An Analysis Differentiated by Sex"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3577-3439","authenticated-orcid":false,"given":"Marcelo de Maio","family":"Nascimento","sequence":"first","affiliation":[{"name":"Department of Physical Education, Federal University of Vale do S\u00e3o Francisco, Petrolina 56304-917, Brazil"},{"name":"Swiss Center of Expertise in Life Course Research LIVES, 1227 Carouge, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-7771","authenticated-orcid":false,"given":"Adilson","family":"Marques","sequence":"additional","affiliation":[{"name":"CIPER, Faculty of Human Kinetics, University of Lisbon, 1649-004 Lisbon, Portugal"},{"name":"ISAMB, University of Lisbon, 1649-004 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-6576","authenticated-orcid":false,"given":"Gerson","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia 7500912, Chile"},{"name":"Escuela de Ciencias de la Actividad F\u00edsica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago 9170022, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-692X","authenticated-orcid":false,"given":"\u00c9lvio R\u00fabio","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Swiss Center of Expertise in Life Course Research LIVES, 1227 Carouge, Switzerland"},{"name":"Department of Physical Education and Sport, University of Madeira, 9000-072 Funchal, Portugal"},{"name":"Laboratory of Robotics and Engineering Systems (LARSYS), Interactive Technologies Institute, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-5190","authenticated-orcid":false,"given":"Andreas","family":"Ihle","sequence":"additional","affiliation":[{"name":"Swiss Center of Expertise in Life Course Research LIVES, 1227 Carouge, Switzerland"},{"name":"Center for the Interdisciplinary Study of Gerontology and Vulnerability, University of Geneva, 1227 Carouge, Switzerland"},{"name":"Department of Psychology, University of Geneva, 1227 Carouge, Switzerland"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,10]]},"reference":[{"key":"ref_1","unstructured":"WHO-World Hearth Organization (2024, September 20). Depressive Disorder (Depression), Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression."},{"key":"ref_2","unstructured":"WHO-World Health Organization (2024, September 28). Depression and Other Common Mental Disorders: Global Health Estimates, Available online: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/934574."},{"key":"ref_3","unstructured":"WHO-World Hearth Organization (2024, September 28). Global Health Estimates, Available online: https:\/\/www.who.int\/data\/global-health-estimates."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101805","DOI":"10.1016\/j.arr.2022.101805","article-title":"Major depression and the biological hallmarks of aging","volume":"83","author":"Lorenzo","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/NDT.S146098","article-title":"Functional impairment in patients with major depressive disorder: The 2-year PERFORM study","volume":"14","author":"Haro","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1080\/13607863.2018.1506742","article-title":"Social isolation, cognitive reserve, and cognition in older people with depression and anxiety","volume":"23","author":"Evans","year":"2019","journal-title":"Aging Ment. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jad.2006.10.010","article-title":"Subsyndromal depression: An impact on quality of life?","volume":"100","year":"2007","journal-title":"J. Affect. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s40273-016-0389-9","article-title":"Health, Health-Related Quality of Life, and Quality of Life: What is the Difference?","volume":"34","author":"Karimi","year":"2016","journal-title":"Pharmacoeconomics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/opn.12089","article-title":"Quality of life in old age\u2014A concept analysis","volume":"11","author":"Boggatz","year":"2016","journal-title":"Int. J. Older People Nurs."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2788.2005.00738.x","article-title":"Moving from the quality of life concept to a theory","volume":"49","author":"Cummins","year":"2005","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1352\/1944-7558-121.1.1","article-title":"Moving Us Toward a Theory of Individual Quality of Life","volume":"121","author":"Schalock","year":"2016","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/jech.2007.066787","article-title":"The welfare state: A glossary for public health","volume":"62","author":"Eikemo","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1017\/S0959259807002262","article-title":"Self-assessment of health and social care needs by older people","volume":"16","author":"Harris","year":"2006","journal-title":"Rev. Clin. Gerontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1590\/S0034-8910.2014048005243","article-title":"Dimensions of self-rated health in older adults","volume":"48","author":"Borim","year":"2014","journal-title":"Rev. Saude Publica"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jad.2018.08.044","article-title":"Relationship of depression, chronic disease, self-rated health, and gender with health care utilization among community-living elderly","volume":"241","author":"Han","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s40279-021-01468-z","article-title":"Is Physical Activity Associated with Less Depression and Anxiety During the COVID-19 Pandemic? A Rapid Systematic Review","volume":"51","author":"Wolf","year":"2021","journal-title":"Sport. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br. J. Sports Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.arr.2017.06.003","article-title":"Physical activity and healthy ageing: A systematic review and meta-analysis of longitudinal cohort studies","volume":"38","author":"Daskalopoulou","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/sms.13616","article-title":"Consequences of physical inactivity in older adults: A systematic review of reviews and meta-analyses","volume":"30","author":"Cunningham","year":"2020","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.arr.2017.05.007","article-title":"Role of physical exercise on cognitive function in healthy older adults: A systematic review of randomized clinical trials","volume":"37","author":"Izquierdo","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113738","DOI":"10.1016\/j.psychres.2021.113738","article-title":"Physical activity and depression in older adults: The knowns and unknowns","volume":"297","author":"Zhang","year":"2021","journal-title":"Psychiatry Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114791","DOI":"10.1016\/j.bbr.2023.114791","article-title":"Possible role of exercise therapy on depression: Effector neurotransmitters as key players","volume":"459","year":"2024","journal-title":"Behav. Brain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1007\/s11033-021-06330-z","article-title":"Molecular mechanisms of physical exercise on depression in the elderly: A systematic review","volume":"48","author":"Cassilhas","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Malm, C., Jakobsson, J., and Isaksson, A. (2019). Physical Activity and Sports\u2014Real Health Benefits: A Review with Insight into the Public Health of Sweden. Sports, 7.","DOI":"10.3390\/sports7050127"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Grasdalsmoen, M., Eriksen, H.R., L\u00f8nning, K.J., and Sivertsen, B. (2020). Physical exercise, mental health problems, and suicide attempts in university students. BMC Psychiatry, 20.","DOI":"10.1186\/s12888-020-02583-3"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114024","DOI":"10.1016\/j.socscimed.2021.114024","article-title":"Associations between self-rated health and depressive symptoms among older adults: Does age matter?","volume":"280","author":"Peleg","year":"2021","journal-title":"Soc. Sci. Med."},{"key":"ref_27","first-page":"1","article-title":"Different levels of physical activity and depression symptoms among older adults from 18 countries: A population-based study from the Survey of Health, Ageing and Retirement in Europe (SHARE)","volume":"21","author":"Marques","year":"2020","journal-title":"Eur. J. Sport Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/tbm\/ibz198","article-title":"A systematic review of physical activity and quality of life and well-being","volume":"10","author":"Marquez","year":"2020","journal-title":"Transl. Behav. Med."},{"key":"ref_29","first-page":"450","article-title":"The Association Between Physical Activity and Self-Rated Health Among Older Adults","volume":"29","author":"Hita","year":"2021","journal-title":"J. Popul. Soc. Stud."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhao, L., Han, G., Zhao, Y., Jin, Y., Ge, T., Yang, W., Cui, R., Xu, S., and Li, B. (2020). Gender Differences in Depression: Evidence From Genetics. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.562316"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113354","DOI":"10.1016\/j.socscimed.2020.113354","article-title":"Depression in women and men, cumulative disadvantage and gender inequality in 29 European countries","volume":"267","author":"Bracke","year":"2020","journal-title":"Soc. Sci. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lee, K.H., Xu, H., and Wu, B. (2020). Gender differences in quality of life among community-dwelling older adults in low- and middle-income countries: Results from the Study on global AGEing and adult health (SAGE). BMC Public Health, 20.","DOI":"10.1186\/s12889-020-8212-0"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"B\u00f6rsch-Supan, A., Bristle, J., Andersen-Ranberg, K., Brugiavini, A., Jusot, F., Litwin, H., and Weber, G. (2019). Health and Socio-Economic Status over the Life Course, De Gruyter. Available online: https:\/\/www.degruyter.com\/document\/doi\/10.1515\/9783110617245\/html.","DOI":"10.1515\/9783110617245"},{"key":"ref_34","unstructured":"Borrat-Besson, C., Ryser, V.A., and Gon\u00e7alves, J. (2024, September 30). An evaluation of the CASP-12 scale used in the Survey of Health, Ageing and Retirement in Europe (SHARE) to measure Quality of Life among people aged 50. Lausanne FORS, Available online: www.share-project.org."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11205-007-9220-5","article-title":"The Evaluation of a Self-enumerated Scale of Quality of Life (CASP-19) in the Context of Research on Ageing: A Combination of Exploratory and Confirmatory Approaches","volume":"89","author":"Wiggins","year":"2008","journal-title":"Soc. Indic. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1192\/bjp.174.4.330","article-title":"Development of the EURO-D scale\u2014A European, Union initiative to compare symptoms of depression in 14 European centres","volume":"174","author":"Prince","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00038-016-0919-4","article-title":"Cross-sectional and prospective relationship between physical activity and chronic diseases in European older adults","volume":"62","author":"Marques","year":"2017","journal-title":"Int. J. Public Health"},{"key":"ref_38","unstructured":"WHO-World Health Organization (2024, September 30). Overweight and Obesity, Available online: https:\/\/www.oecd-ilibrary.org\/social-issues-migration-health\/health-at-a-glance-asia-pacific-2020_a47d0cd2-en."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1108\/S0195-6310(2013)0000030017","article-title":"The International Standard Classification of Education 2011","volume":"Volume 30","author":"Schneider","year":"2013","journal-title":"Comparative Social Research"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hansen, H., Sch\u00e4fer, I., Sch\u00f6n, G., Riedel-Heller, S., Gensichen, J., Weyerer, S., Petersen, J.J., K\u00f6nig, H.-H., Bickel, H., and Fuchs, A. (2014). Agreement between self-reported and general practitioner-reported chronic conditions among multimorbid patients in primary care\u2014Results of the MultiCare Cohort Study. BMC Fam. Pract., 15.","DOI":"10.1186\/1471-2296-15-39"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., and Salvioli, S. (2018). The continuum of aging and age-related diseases: Common mechanisms but different rates. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00061"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3928\/00989134-20170223-03","article-title":"Definition, Determinants, and Outcomes of Social Connectedness for Older Adults: A Scoping Review","volume":"43","author":"Sidani","year":"2017","journal-title":"J. Gerontol. Nurs."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Aiken, L.S., West, S.G., and Pitts, S.C. (2003). Multiple Linear Regression. Handbook of Psychology, John Wiley & Sons, Inc.","DOI":"10.1002\/0471264385.wei0219"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3758\/BF03206553","article-title":"SPSS and SAS procedures for estimating indirect effects in simple mediation models","volume":"36","author":"Preacher","year":"2004","journal-title":"Behav. Res. Methods, Instruments, Comput."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00273170701341316","article-title":"Addressing Moderated Mediation Hypotheses: Theory, Methods, and Prescriptions","volume":"42","author":"Preacher","year":"2007","journal-title":"Multivariate Behav. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/01.ede.0000147107.76079.07","article-title":"The Mediation Proportion","volume":"16","author":"Ditlevsen","year":"2005","journal-title":"Epidemiology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1198\/000313001317097960","article-title":"On judging the significance of differences by examining the overlap between confidence intervals","volume":"55","author":"Schenker","year":"2001","journal-title":"Am. Stat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.eurpsy.2009.11.009","article-title":"Depression in middle-aged and older first generation migrants in Europe: Results from the Survey of Health, Ageing and Retirement in Europe (SHARE)","volume":"25","author":"Aichberger","year":"2010","journal-title":"Eur. Psychiatry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1017\/S0144686X18001149","article-title":"Assessing the impact of partial early retirement on self-perceived health, depression level and quality of life in Belgium: A longitudinal perspective using the Survey of Health, Ageing and Retirement in Europe (SHARE)","volume":"40","author":"Wels","year":"2020","journal-title":"Ageing Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.regg.2020.05.005","article-title":"Diferencias en funci\u00f3n de la edad y la autopercepci\u00f3n del envejecimiento en ansiedad, tristeza, soledad y sintomatolog\u00eda com\u00f3rbida ansioso-depresiva durante el confinamiento por la COVID-19","volume":"55","year":"2020","journal-title":"Rev. Esp. Geriatr. Gerontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s11482-013-9278-y","article-title":"Between Country Variations in Self-Rated-Health and Associations with the Quality of Life of Older People: Evidence from the Global Ageing Survey","volume":"9","author":"Khan","year":"2014","journal-title":"Appl. Res. Qual. Life"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/13607863.2021.2013434","article-title":"Sex differences in quality of life and depressive symptoms among middle-aged and elderly Europeans: Results from the SHARE survey","volume":"27","author":"Olsen","year":"2023","journal-title":"Aging Ment. Health"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ssresearch.2017.08.003","article-title":"Depression in later life: A closer look at the gender gap","volume":"68","author":"Acciai","year":"2017","journal-title":"Soc. Sci. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/1099800418776082","article-title":"Biological Sex Differences in Depression: A Systematic Review","volume":"20","author":"Labaka","year":"2018","journal-title":"Biol. Res. Nurs."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/07317115.2015.1132290","article-title":"Coping: Impact of Gender and Stressful Life Events in Middle and in Old Age","volume":"39","author":"Rubio","year":"2016","journal-title":"Clin. Gerontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jad.2010.11.033","article-title":"Age- and gender-specific prevalence of depression in latest-life\u2014Systematic review and meta-analysis","volume":"136","author":"Luppa","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2019.01.006","article-title":"Sex differences in depression: Insights from clinical and preclinical studies","volume":"176","author":"Eid","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Penninx, B.W.J.H., Milaneschi, Y., Lamers, F., and Vogelzangs, N. (2013). Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-129"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00406-017-0778-x","article-title":"Gender differences in subtypes of depression by first incidence and age of onset: A follow-up of the Lundby population","volume":"268","author":"Bogren","year":"2018","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1177\/070674371005501002","article-title":"Life Course Perspectives on the Epidemiology of Depression","volume":"55","author":"Colman","year":"2010","journal-title":"Can. J. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2023.11.065","article-title":"Exploring sex differences regarding the mediation of the relationship between depression and quality of life via moderate and vigorous physical activity in old age: A longitudinal study","volume":"347","author":"Marques","year":"2024","journal-title":"J. Affect. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcjd.2014.11.006","article-title":"Depression and Risk for Diabetes: A Meta-Analysis","volume":"39","author":"Yu","year":"2015","journal-title":"Can. J. Diabetes"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12966-020-01037-z","article-title":"2020 WHO guidelines on physical activity and sedentary behaviour for children and adolescents aged 5\u201317 years: Summary of the evidence","volume":"17","author":"Chaput","year":"2020","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1176\/appi.ajp.2018.17111194","article-title":"Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies","volume":"175","author":"Schuch","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/jamapsychiatry.2022.0609","article-title":"Association Between Physical Activity and Risk of Depression","volume":"79","author":"Pearce","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/bjsports-2022-106195","article-title":"Effectiveness of physical activity interventions for improving depression, anxiety and distress: An overview of systematic reviews","volume":"57","author":"Singh","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"ref_67","first-page":"235","article-title":"Self-rated health and physical activity in the European Union","volume":"49","author":"Robine","year":"2004","journal-title":"Soz. Praventivmed."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3424972","DOI":"10.1155\/2022\/3424972","article-title":"A Meta-Analysis to Detect Efficacy of Physical Activity Interventions to Enhance Effects Related to the Fragility among Older Adults","volume":"2022","author":"Xi","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jamapsychiatry.2018.4175","article-title":"Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults","volume":"76","author":"Choi","year":"2019","journal-title":"JAMA Psychiatry"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6760\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:29:42Z","timestamp":1760113782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/22\/6760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,10]]},"references-count":69,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["jcm13226760"],"URL":"https:\/\/doi.org\/10.3390\/jcm13226760","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,10]]}}}