{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:34:54Z","timestamp":1773873294444,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese National Funds","award":["2020.07476.BD"],"award-info":[{"award-number":["2020.07476.BD"]}]},{"name":"Portuguese National Funds","award":["DL57\/2016\/CP1361\/CT0006"],"award-info":[{"award-number":["DL57\/2016\/CP1361\/CT0006"]}]},{"name":"Portuguese National Funds","award":["EXPL\/BTM-TEC\/0990\/2021"],"award-info":[{"award-number":["EXPL\/BTM-TEC\/0990\/2021"]}]},{"name":"Portuguese National Funds","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Portuguese National Funds","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"Portuguese National Funds","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"Portuguese National Funds","award":["41\/ALG\/2020"],"award-info":[{"award-number":["41\/ALG\/2020"]}]},{"name":"Portuguese National Funds","award":["072583"],"award-info":[{"award-number":["072583"]}]},{"name":"Portuguese National Funds","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"AAC","award":["2020.07476.BD"],"award-info":[{"award-number":["2020.07476.BD"]}]},{"name":"AAC","award":["DL57\/2016\/CP1361\/CT0006"],"award-info":[{"award-number":["DL57\/2016\/CP1361\/CT0006"]}]},{"name":"AAC","award":["EXPL\/BTM-TEC\/0990\/2021"],"award-info":[{"award-number":["EXPL\/BTM-TEC\/0990\/2021"]}]},{"name":"AAC","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"AAC","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"AAC","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"AAC","award":["41\/ALG\/2020"],"award-info":[{"award-number":["41\/ALG\/2020"]}]},{"name":"AAC","award":["072583"],"award-info":[{"award-number":["072583"]}]},{"name":"AAC","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["2020.07476.BD"],"award-info":[{"award-number":["2020.07476.BD"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["DL57\/2016\/CP1361\/CT0006"],"award-info":[{"award-number":["DL57\/2016\/CP1361\/CT0006"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["EXPL\/BTM-TEC\/0990\/2021"],"award-info":[{"award-number":["EXPL\/BTM-TEC\/0990\/2021"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["41\/ALG\/2020"],"award-info":[{"award-number":["41\/ALG\/2020"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["072583"],"award-info":[{"award-number":["072583"]}]},{"name":"Portuguese Society of Nephrology (SPN)","award":["2019"],"award-info":[{"award-number":["2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Vascular calcification (VC) is a crucial risk factor for cardiovascular diseases (CVD), particularly in chronic kidney disease (CKD) populations. However, the specific relationship between VC and end-stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD) remains to be fully understood. The identification of new biomarkers to improve VC diagnosis and monitoring would significantly impact cardiovascular risk management in these high-risk patients. Gla-rich protein (GRP) is a VC inhibitor and an anti-inflammatory agent and thus is a potential VC marker in CKD. Here we explored the potential role of GRP as a marker for CVD and investigated the impact of VC in 101 PD patients. Methods: Circulating total Gla-rich protein (tGRP) was quantified in serum and in 24 h dialysate samples. VC score (VCS) was determined using the Adrag\u00e3o method. Results: Serum tGRP was negatively associated with VCS, serum calcium (Ca), phosphate (P), and high-sensitivity C-reactive protein (hsCRP), while it was positively associated with magnesium (Mg). A total of 35.6% of PD patients presented with extensive calcifications (VCS \u2265 3), and the lowest tGRP serum levels were present in this group (419.4 \u00b1 198.5 pg\/mL). tGRP in the 24 h dialysate was also negatively associated with VCS and with serum Ca and P. Moreover, serum Ca, P, and VCS were identified as independent determinants of serum tGRP levels. Conclusions: The association of serum tGRP with VC, mineral, and inflammation markers reinforces its potential use as a novel VC biomarker in CKD patients undergoing PD.<\/jats:p>","DOI":"10.3390\/jcm13237429","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T03:44:47Z","timestamp":1733456687000},"page":"7429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gla-Rich Protein Is Associated with Vascular Calcification, Inflammation, and Mineral Markers in Peritoneal Dialysis Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Catarina","family":"Marreiros","sequence":"first","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal"}]},{"given":"Carla","family":"Viegas","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"GenoGla Diagnostics, CCMAR, Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"given":"Anabela Malho","family":"Guedes","sequence":"additional","affiliation":[{"name":"Unidade local de Sa\u00fade do Algarve, Centro Hospitalar Universit\u00e1rio do Algarve (CHUA), 8000-386 Faro, Portugal"},{"name":"Faculdade de Medicina e Ci\u00eancias Biom\u00e9dicas, Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"given":"Ana Paula","family":"Silva","sequence":"additional","affiliation":[{"name":"Unidade local de Sa\u00fade do Algarve, Centro Hospitalar Universit\u00e1rio do Algarve (CHUA), 8000-386 Faro, Portugal"},{"name":"Faculdade de Medicina e Ci\u00eancias Biom\u00e9dicas, Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"given":"Ana Catarina","family":"\u00c1guas","sequence":"additional","affiliation":[{"name":"Servi\u00e7o Radiologia, Centro Hospitalar Universit\u00e1rio do Algarve (CHUA), 8000-386 Faro, Portugal"}]},{"given":"Mar\u00edlia","family":"Fa\u00edsca","sequence":"additional","affiliation":[{"name":"SYNLAB Algarve, 8000-307 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-6957","authenticated-orcid":false,"given":"Leon","family":"Schurgers","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cardiovascular, Maastricht University, 6229 HX Maastricht, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-4753","authenticated-orcid":false,"given":"Dina Costa","family":"Simes","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal"},{"name":"GenoGla Diagnostics, CCMAR, Universidade do Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular Disease in Chronic Kidney Disease","volume":"143","author":"Jankowski","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2310909","DOI":"10.1001\/jamanetworkopen.2023.10909","article-title":"Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw. 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Nephrol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:48:12Z","timestamp":1760114892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/23\/7429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,6]]},"references-count":46,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcm13237429"],"URL":"https:\/\/doi.org\/10.3390\/jcm13237429","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,6]]}}}