{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:16:07Z","timestamp":1760058967808,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\/MCTES","award":["10.54499\/UIDB\/04585\/2020"],"award-info":[{"award-number":["10.54499\/UIDB\/04585\/2020"]}]},{"name":"national funds","award":["10.54499\/UIDB\/04585\/2020"],"award-info":[{"award-number":["10.54499\/UIDB\/04585\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Oral cancer is a significant global public health concern. Understanding the prevalence and associated risk factors of oral lesions is essential for developing effective preventive strategies. This study aimed to assess the prevalence and risk factors of oral lesions submitted for biopsy in a Portuguese subpopulation. A retrospective cross-sectional analysis was conducted using data from patients who sought dental care at the Egas Moniz Dental Clinic (EMDC) in the Lisbon metropolitan area. Methods: Data analysis was performed on a sample of 264 patients who attended the EMDC between October 2016 and December 2019 to ascertain the presence of oral lesions, their different types, and their correlation with potential risk factors. The analysis included all patients who underwent biopsy, and their pathology reports were reviewed. Results: The prevalence of oral lesions was 10.3%, affecting 58.7% females and 41.3% males, with a mean age of 55 years. The most frequently biopsied site was the buccal mucosa (23.5%). Non-neoplastic lesions accounted for 75.0% of cases, while mesenchymal lesions were the most common neoplastic category (58.5%). The most prevalent diagnosis was fibroepithelial hyperplasia (36.7%). A statistically significant association was observed between neoplastic lesions and statin use, as well as between both neoplastic and non-neoplastic lesions and the use of antidiabetic medications. Conclusions: Oral lesions are prevalent, with non-neoplastic lesions being the most frequent. Understanding their nature, prevalence, and associated risk factors is crucial for early and accurate diagnosis, aiding in disease prevention and management.<\/jats:p>","DOI":"10.3390\/jcm14103294","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T04:13:44Z","timestamp":1746764024000},"page":"3294","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Risk Factors of Oral Lesions in a Portuguese Subpopulation: A Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Carolina","family":"Doroteia","sequence":"first","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-514X","authenticated-orcid":false,"given":"Gon\u00e7alo Martins","family":"Pereira","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-5936","authenticated-orcid":false,"given":"Lu\u00eds","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4077","authenticated-orcid":false,"given":"Jos\u00e9 Jo\u00e3o","family":"Mendes","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-9646","authenticated-orcid":false,"given":"Maria Alzira","family":"Cavacas","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.det.2020.05.003","article-title":"Oral Biopsy Techniques","volume":"38","author":"Shanti","year":"2020","journal-title":"Dermatol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101673","DOI":"10.1016\/j.eclinm.2022.101673","article-title":"Stark Differences in Cancer Epidemiological Data Between GLOBOCAN and GBD: Emphasis on Oral Cancer and Wider Implications","volume":"54","author":"Fan","year":"2022","journal-title":"EClinicalMedicine"},{"key":"ref_4","unstructured":"International Agency for Research on Cancer (IARC)\/World Health Organization (WHO) (2025, March 05). Global Cancer Observatory: Cancer Today. Portugal. Available online: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/620-portugal-fact-sheet.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/jop.12264","article-title":"Prevalence and distribution of oral mucosal lesions: A cross-sectional study in Shanghai, China","volume":"44","author":"Feng","year":"2015","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_6","first-page":"4030134","article-title":"Prevalence and distribution of oral mucosal lesions by sex and age categories: A retrospective study of patients attending Lebanese School of Dentistry","volume":"2018","author":"Cassia","year":"2018","journal-title":"Int. J. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ertem, S.Y., and Uz, F. (2025). An assessment of the distribution and prevalence of benign intraoral pathologies. Diagnostics, 15.","DOI":"10.3390\/diagnostics15030350"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Abati, S., Bramati, C., Bondi, S., Lissoni, A., and Trimarchi, M. (2020). Oral cancer and precancer: A narrative review on the relevance of early diagnosis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17249160"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jop.12726","article-title":"Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis","volume":"47","author":"Mello","year":"2018","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_10","unstructured":"World Health Organization (2022). Global Oral Health Status Report: Towards Universal Health Coverage for Oral Health by 2030, WHO."},{"key":"ref_11","unstructured":"Business Council for Sustainable Development (2024, June 15). Objetivo 3: Sa\u00fade de Qualidade. Available online: https:\/\/ods.pt\/objectivos\/3-vida-saudavel\/."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.adaj.2016.10.001","article-title":"A New Definition for Oral Health Developed by the FDI World Dental Federation Opens the Door to a Universal Definition of Oral Health","volume":"147","author":"Glick","year":"2016","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.jfma.2021.10.018","article-title":"Oral Health: The First Step to Sustainable Development Goal 3","volume":"121","author":"Huang","year":"2022","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_14","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology (2024). Guidelines for ATC Classification and DDD Assignment 2025, Norwegian Institute of Public Health. [25th ed.]."},{"key":"ref_15","unstructured":"World Health Organization, Classification of Tumours Editorial Board (2023). Head and Neck Tumours, International Agency for Research on Cancer. [5th ed.]."},{"key":"ref_16","unstructured":"World Health Organization (2016). International Statistical Classification of Diseases and Related Health Problems, WHO. [10th ed.]."},{"key":"ref_17","unstructured":"\u00c1rea Metropolitana de Lisboa (2024, November 04). Munic\u00edpios AML. Available online: www.aml.pt\/index.php."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/idj.12258","article-title":"A Comparative Analysis of Oral and Maxillofacial Pathology Over a 16-Year Period, in the North of Portugal","volume":"67","author":"Monteiro","year":"2017","journal-title":"Int. Dent. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Oivio, U.M., Pesonen, P., Ylipalosaari, M., Kullaa, A., and Salo, T. (2020). Prevalence of Oral Mucosal Normal Variations and Lesions in a Middle-Aged Population: A Northern Finland Birth Cohort 1966 Study. BMC Oral. Health, 20.","DOI":"10.1186\/s12903-020-01351-9"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0970-9290.29877","article-title":"Prevalence of Oral Lesions in Relation to Habits: Cross-Sectional Study in South India","volume":"17","author":"Saraswathi","year":"2006","journal-title":"Indian J. Dent. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/0256-4947.55166","article-title":"Prevalence of oral lesions among Saudi dental patients","volume":"29","author":"AlDosari","year":"2009","journal-title":"Ann. Saudi Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1601-0825.2006.01235.x","article-title":"Prevalence of oral lesions in 13- to 16-year-old students in Duzce, Turkey","volume":"12","author":"Parlak","year":"2006","journal-title":"Oral. Dis."},{"key":"ref_23","first-page":"504","article-title":"Prevalence of oral lesions in the dental office","volume":"57","author":"Demko","year":"2009","journal-title":"Gen. Dent."},{"key":"ref_24","first-page":"142","article-title":"Prevalence of oral lesions and normal variants of the oral mucosa in 12 to 15-year-old students in Tehran, Iran","volume":"15","author":"Jahanbani","year":"2012","journal-title":"Arch. Iran. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1016\/j.oooo.2017.05.344","article-title":"A retrospective study of the incidence of oral lesions of soft tissue referenced in a Brazilian town","volume":"124","author":"Blanco","year":"2017","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/2525-5711.20160002","article-title":"Prevalence of oral and maxillofacial diseases diagnosed in an Oral Medicine service during a 7-year period","volume":"1","author":"Amaral","year":"2016","journal-title":"J. Oral. Diagn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.4103\/jfmpc.jfmpc_344_19","article-title":"Prevalence and risk indicators of oral mucosal lesions in adult population visiting primary health centers and community health centers in Kodagu district","volume":"8","author":"Kumar","year":"2019","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.54589\/aol.34\/3\/249","article-title":"Prevalence of oral mucosal lesions in an adult population from eight communities in Santo Domingo, Dominican Republic","volume":"34","author":"Collins","year":"2021","journal-title":"Acta Odontol. Latinoam."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"362","DOI":"10.31729\/jnma.3283","article-title":"Prevalence of oral mucosal lesions in a tertiary care dental hospital of Kathmandu","volume":"56","author":"Bajracharya","year":"2017","journal-title":"JNMA J. Nepal. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/adj.12175","article-title":"A retrospective analysis of oral and maxillofacial pathology in an Australian adult population","volume":"59","author":"Kelloway","year":"2014","journal-title":"Aust. Dent. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1034\/j.1600-0714.2001.300104.x","article-title":"Oral mucosal lesions and risk habits among men in an Italian study population","volume":"30","author":"Campisi","year":"2001","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.14219\/jada.archive.2004.0403","article-title":"The prevalence of oral mucosal lesions in U.S. adults: Data from the Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"135","author":"Shulman","year":"2004","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_33","unstructured":"Institute of Health Metrics and Evaluation (2020). Global Burden of Disease 2019 (GBD 2019) Results, IHME. Available online: https:\/\/vizhub.healthdata.org\/gbd-results\/."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Gupta, A., Shrestha, P., Poudyal, S., Kumar, S., Lamichhane, R.S., Acharya, S.K., and Shivhare, P. (2023). Prevalence and distribution of oral mucosal lesions and normal variants among Nepalese population. Biomed. Res. Int., 2023.","DOI":"10.1155\/2023\/9375084"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.4317\/jced.3.e10","article-title":"The prevalence of oral mucosal lesions in the patients visiting a dental school in Northern India in relation to sex, site and distribution: A retrospective study","volume":"3","author":"Gambhir","year":"2011","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/odi.12488","article-title":"Prevalence and factors associated with oral potentially malignant disorders in Brazil\u2019s rural workers","volume":"22","author":"Ferreira","year":"2016","journal-title":"Oral. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1601-0825.2010.01712.x","article-title":"Prevalence and risk indicators of oral mucosal lesions in an urban population from South Brazil","volume":"17","author":"Carrard","year":"2011","journal-title":"Oral. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1601-0825.2007.01391.x","article-title":"The prevalence of oral mucosal lesions in adults from the Turin area","volume":"14","author":"Pentenero","year":"2008","journal-title":"Oral. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/2230-8229.108183","article-title":"Prevalence study of oral mucosal lesions, mucosal variants, and treatment required for patients reporting to a dental school in North India: In accordance with WHO guidelines","volume":"20","author":"Bhatnagar","year":"2013","journal-title":"J. Fam. Community Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mehrotra, R., Thomas, S., Nair, P., Pandya, S., Singh, M., Nigam, N.S., and Shukla, P. (2010). Prevalence of oral soft tissue lesions in Vidisha. BMC Res. Notes, 3.","DOI":"10.1186\/1756-0500-3-23"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1600-0714.2005.00332.x","article-title":"Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan","volume":"34","author":"Chung","year":"2005","journal-title":"J. Oral. Pathol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.oooo.2018.03.011","article-title":"Clinical features and presentation of oral potentially malignant disorders","volume":"125","author":"Warnakulasuriya","year":"2018","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_43","first-page":"e16","article-title":"An analysis of oral biopsies extracted from 1995 to 2009, in an oral medicine and surgery unit in Galicia (Spain)","volume":"17","year":"2012","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/odi.13323","article-title":"Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1368-8375(03)00139-8","article-title":"Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: A follow-up study in an Italian population","volume":"40","author":"Gandolfo","year":"2004","journal-title":"Oral Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(16)00645-0","article-title":"Infantile haemangioma","volume":"390","author":"Harper","year":"2017","journal-title":"Lancet"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Chowdhury, R., and Satoskar, R. (2012). Surveillance for hepatocellular carcinoma. Primary Liver Cancer: Surveillance, Diagnosis and Treatment, Humana Press Inc.","DOI":"10.1007\/978-1-61779-863-4_2"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1177\/00220345010800052001","article-title":"Oral mucosal lesions in adult Chinese","volume":"80","author":"Lin","year":"2001","journal-title":"J. Dent. Res."},{"key":"ref_49","unstructured":"Instituto Nacional de Estat\u00edstica (2024, June 14). Censos 2021 Resultados Definitivos\u2014Portugal, Available online: https:\/\/www.sgeconomia.gov.pt\/noticias\/ine-censos-resultados-definitivos-2021.aspx."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104157","DOI":"10.1016\/j.jdent.2022.104157","article-title":"Comparing oral health behaviours of men and women in the United States","volume":"122","author":"Su","year":"2022","journal-title":"J. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1034\/j.1600-0714.2003.00031.x","article-title":"Prevalence of oral mucosal lesions in elderly people in Santiago, Chile","volume":"32","author":"Espinoza","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rumgay, H., Murphy, N., Ferrari, P., and Soerjomataram, I. (2021). Alcohol and cancer: Epidemiology and biological mechanisms. Nutrients, 13.","DOI":"10.3390\/nu13093173"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hed.23933","article-title":"Oropharyngeal cancer as a driver of racial outcome disparities in squamous cell carcinoma of the head and neck: 10-year experience at the University of Maryland Greenebaum Cancer Center","volume":"38","author":"Zandberg","year":"2016","journal-title":"Head Neck"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"S1806-83242015000100289","DOI":"10.1590\/1807-3107BOR-2015.vol29.0093","article-title":"Oral mucosal lesions and their association with sociodemographic, behavioral, and health status factors","volume":"29","author":"Gheno","year":"2015","journal-title":"Braz. Oral Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/abd1806-4841.20153089","article-title":"Prevalence of oral mucosal lesions among patients with diabetes mellitus types 1 and 2","volume":"90","author":"Silva","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1808-8694(15)30578-4","article-title":"Prevalence of oral mucosa lesions in diabetic patients: A preliminary study","volume":"74","author":"Vasconcelos","year":"2008","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1067\/moe.2000.104477","article-title":"Insulin-dependent diabetes mellitus and oral soft tissue pathologies: II. Prevalence and characteristics of Candida and candidal lesions","volume":"89","author":"Guggenheimer","year":"2000","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/ijc.30526","article-title":"Effects of statins on cancer mortality and progression: A systematic review and meta-analysis of 95 cohorts including 1,111,407 individuals","volume":"140","author":"Mei","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejca.2020.10.031","article-title":"High-intensity statins are associated with improved clinical activity of PD-1 inhibitors in malignant pleural mesothelioma and advanced non-small cell lung cancer patients","volume":"144","author":"Cantini","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jdent.2017.08.011","article-title":"The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-a systematic review and meta-analysis","volume":"67","author":"Bertl","year":"2017","journal-title":"J. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rakhmatia, Y.D., Ayukawa, Y., Furuhashi, A., and Koyano, K. (2018). Carbonate apatite containing statin enhances bone formation in healing incisal extraction sockets in rats. Materials, 11.","DOI":"10.3390\/ma11071201"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1902\/jop.2016.160536","article-title":"Fluvastatin inhibits osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone erosion in mice","volume":"88","author":"Pokhrel","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ijom.2017.12.009","article-title":"The ability of topical and systemic statins to increase osteogenesis around dental implants: A systematic review of histomorphometric outcomes in animal studies","volume":"47","author":"Moraschini","year":"2018","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.joen.2012.12.036","article-title":"Effect of statins with \u03b1-tricalcium phosphate on proliferation, differentiation, and mineralization of human dental pulp cells","volume":"39","author":"Varalakshmi","year":"2013","journal-title":"J. Endod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15171\/joddd.2016.001","article-title":"Evaluation of the effects of subgingival injection of simvastatin on space re-opening after orthodontic space closure in adults","volume":"10","author":"Jahanbin","year":"2016","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/00016357.2017.1403648","article-title":"Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure","volume":"76","author":"Madi","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.2147\/DDDT.S105809","article-title":"Simvastatin attenuates radiation-induced salivary gland dysfunction in mice","volume":"10","author":"Xu","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e147096","DOI":"10.1172\/jci.insight.147096","article-title":"Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions","volume":"6","author":"Gutkind","year":"2021","journal-title":"JCI Insight"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wei, J., Huang, J., Kuang, Y., Li, Y., Zhong, D., and Song, J. (2021). Metformin inhibits proliferation of oral squamous cell carcinoma cells by suppressing proteolysis of nerve growth factor receptor. Arch. Oral Biol., 121.","DOI":"10.1016\/j.archoralbio.2020.104971"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3294\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:29:49Z","timestamp":1760030989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14103294"],"URL":"https:\/\/doi.org\/10.3390\/jcm14103294","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,5,9]]}}}