{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:55:52Z","timestamp":1774115752399,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009032","name":"Pfizer","doi-asserted-by":"publisher","award":["59852013"],"award-info":[{"award-number":["59852013"]}],"id":[{"id":"10.13039\/100009032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Carpal tunnel syndrome (CTS) has emerged as an early indicator of cardiac amyloidosis (CA) caused by transthyretin-associated (ATTR) mutations, possibly linked to adverse cardiovascular outcomes. This case series examines the relationship between idiopathic CTS and CA imaging diagnosis. Methods: Twenty-two patients from the cross-sectional study CarPoS (NCT05409833) were included. These patients underwent physical evaluation, laboratory exams, electrocardiography, echocardiography, cardiac magnetic resonance (CMR) imaging, and scintigraphy with 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid. Results: Four of the twenty-two patients included had ATTR cardiomyopathy. These patients presented left-ventricle hypertrophy and signs of infiltrative cardiomyopathy in echocardiograms and late gadolinium enhancement in CMR images without having any cardiovascular symptoms. Conclusions: Our findings suggest a high prevalence of CA in patients with bilateral idiopathic CTS, highlighting the importance of screening for CA in patients with CTS. Early detection could significantly impact patient prognosis, underscoring the need for further research into diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.3390\/jcm14113710","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T04:49:52Z","timestamp":1748234992000},"page":"3710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Screening for Cardiac Amyloidosis When Conducting Carpal Tunnel Surgery"],"prefix":"10.3390","volume":"14","author":[{"given":"Sofia","family":"Pimenta","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7581-4074","authenticated-orcid":false,"given":"Ana","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-1848","authenticated-orcid":false,"given":"Janete","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7010-2104","authenticated-orcid":false,"given":"In\u00eas","family":"Fortuna","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-4128","authenticated-orcid":false,"given":"Barbara","family":"Pereira","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Mariana","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-009X","authenticated-orcid":false,"given":"Miguel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Micaela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Isabel","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Isabel","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Jorge","family":"Pereira","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"Teresa","family":"Faria","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"given":"L\u00facia","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-2953","authenticated-orcid":false,"given":"Elisabete","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Cardiology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E., 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.jacc.2015.09.075","article-title":"Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis","volume":"66","author":"Gertz","year":"2015","journal-title":"J. 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