{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:30:22Z","timestamp":1771500622901,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Acromegaly is caused by an excessive secretion of growth hormone and the secondary elevation of IGF-1 levels, leading to progressive changes in multiple body systems, including the craniofacial region and oral cavity. Dental manifestations such as mandibular overgrowth, macroglossia, malocclusion, periodontal disease, and prosthetic difficulties represent not only a clinical component of the disease but also a significant therapeutic and diagnostic challenge. The aim of this review is to present the current state of knowledge on the relationship between acromegaly and oral health and to analyze the role of interdisciplinary collaboration between endocrinologists and dentists in patient care. For this narrative review, a literature search was conducted in the PubMed, Scopus, and Web of Science databases covering the period from 2000 to 2025. Sixty-two peer-reviewed publications meeting the methodological and thematic criteria were included in the analysis, including original studies, meta-analyses, systematic reviews, and case reports. The results indicate significant correlations between disease activity and the severity of periodontal and microbiological changes, while effective endocrine treatment only results in the partial regression of morphological changes. Particular attention was given to the role of the dentist in recognizing the early symptoms of the disease, planning prosthetic and surgical treatment, and monitoring therapy-related complications. Interdisciplinary collaboration models, including integrated clinics and co-managed care, were also described as optimal systemic solutions for improving treatment quality. The conclusion drawn from the analysis are as follows: there is a need for the permanent integration of dentistry into the standard of interdisciplinary care for patients with acromegaly, in both diagnostic and therapeutic dimensions. Increasing awareness among dentists and developing integrated collaboration models may reduce the time to diagnosis, improve patients\u2019 quality of life, and enable the more effective management of craniofacial complications in the course of this rare disease.<\/jats:p>","DOI":"10.3390\/jcm14155511","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:44:32Z","timestamp":1754401472000},"page":"5511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Collaboration Between Endocrinologists and Dentists in the Care of Patients with Acromegaly\u2014A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Beata","family":"Wi\u015bniewska","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}]},{"given":"Kosma","family":"Piekarski","sequence":"additional","affiliation":[{"name":"Arbor Vitae Society of Ethics in Medicine, 103 Marymoncka Street, 01-813 Warsaw, Poland"}]},{"given":"Sandra","family":"Spycha\u0142a","sequence":"additional","affiliation":[{"name":"Arbor Vitae Society of Ethics in Medicine, 103 Marymoncka Street, 01-813 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-2670","authenticated-orcid":false,"given":"Ewelina","family":"Golusi\u0144ska-Kardach","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}]},{"given":"Maria","family":"Stelmachowska-Bana\u015b","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Centre of Postgraduade Medical Education, 99 Marymoncka Street, 01-813 Warsaw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-2277","authenticated-orcid":false,"given":"Marzena","family":"Wyganowska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1172\/JCI39375","article-title":"Acromegaly pathogenesis and treatment","volume":"119","author":"Melmed","year":"2009","journal-title":"J. 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