{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:40:44Z","timestamp":1760060444125,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia, I.P., within CINTESIS, R&amp;D Unit","award":["UIDB\/4255\/2020","LA\/P\/0053\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020","LA\/P\/0053\/2020"]}]},{"name":"the scope of the project RISE, Associated Laboratory","award":["UIDB\/4255\/2020","LA\/P\/0053\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020","LA\/P\/0053\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Anorexia\u2013Cachexia Syndrome (ACS) is a multifactorial condition common in advanced chronic illnesses, leading to significant impacts on prognosis and quality of life. This retrospective cohort study aimed to evaluate the prevalence, management strategies, and clinical and patient-centered outcomes of ACS in a home-based palliative care team. Methods: Clinical records of 128 adult patients followed between 2021 and 2024 were analyzed. Data collected included sociodemographic variables, clinical diagnosis, nutritional parameters (Palliative Performance Scale (PPS), Mini Nutritional Assessment (MNA)), symptoms (anorexia, fatigue), interventions (enteral nutrition, psychological and rehabilitative support), and relevant medications. Statistical analysis included descriptive, inferential, and multivariable proportional hazard regression analysis to identify independent predictors of weight loss and anorexia. Results: Manifestations of ACS were observed across both oncologic and non-oncologic conditions. The prevalence of weight loss and anorexia were interrelated and were not different between diagnostic groups. Using multivariable analysis, higher baseline MNA scores (HR = 3.797, p = 0.006) and the use of enteral nutrition (HR = 7.418, p = 0.014) were independently associated with an increased risk of significant weight loss. Lower baseline PPS scores (HR = 0.069), use of enteral nutrition (HR = \u22120.890), and the presence of psychological support were protective for subsequent anorexia. Dexamethasone use was associated with greater nutritional decline in univariate models. Conclusions: The management of ACS in home palliative care requires the early identification of symptoms, multidisciplinary intervention, and personalized strategies beyond disease etiology. Risk of weight loss is associated with higher MNA scores, and these are best managed in the first week. In anorexia cases, psychological support is protective.<\/jats:p>","DOI":"10.3390\/jcm14176167","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T13:01:13Z","timestamp":1756818073000},"page":"6167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Anorexia\u2013Cachexia Syndrome in a Community Palliative Care Support Team"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4296-2885","authenticated-orcid":false,"given":"In\u00eas","family":"Saura","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Health Family Unit Aldeias do Xisto, Local Health Unit of Coimbra, 3004-561 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7538-0158","authenticated-orcid":false,"given":"Joana Brand\u00e3o","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Abel Salazar Institute of Biomedical Sciences, 4050-313 Porto, Portugal"},{"name":"Health Family Unit Marco, Local Health Unit T\u00e2mega-Sousa, 4564-007 Penafiel, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-3621","authenticated-orcid":false,"given":"Daniela","family":"Cunha","sequence":"additional","affiliation":[{"name":"Northern School of Health of the Portuguese Red Cross, 3720-126 Aveiro, Portugal"}]},{"given":"Iliana","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"Community Palliative Care Team Gaia, Local Health Unit Gaia and Espinho, 4434-502 Vila Nova de Gaia, Portugal"}]},{"given":"Val\u00e9ria","family":"Semedo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"Palliative Care Unit, University Hospital Agostinho Neto, Cidade da Praia 7600, Cape Verde"},{"name":"Faculty of Science and Technology, University of Cape Verde, Praia 7943, Cape Verde"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-200X","authenticated-orcid":false,"given":"Jos\u00e9 Paulo","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"RISE-Health, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Mar\u00edlia","family":"Dourado","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research, 3000-548 Coimbra, Portugal"}]},{"given":"Hugo","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Department of Biomedicine, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal"},{"name":"Community Palliative Care Team Gaia, Local Health Unit Gaia and Espinho, 4434-502 Vila Nova de Gaia, Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research, 3000-548 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clnu.2016.09.004","article-title":"ESPEN guidelines on definitions and terminology of clinical nutrition","volume":"36","author":"Cederholm","year":"2017","journal-title":"Clin. 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