{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:38:16Z","timestamp":1764092296070,"version":"3.45.0"},"reference-count":26,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Funds through FCT\u2014Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/4255\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pericarotid adipose tissue (PCAT) characteristics and systemic inflammation may play an important role in carotid endarterectomy (CEA) outcomes. This study explores the association between PCAT Hounsfield Unit (HU) ranges, radiomic features, and systemic inflammatory markers in patients undergoing carotid endarterectomy (CEA). Methods: Twenty patients undergoing CEA were included in this cross-sectional study. PCAT was analyzed using preoperative computed tomography angiography (CTA) images, with regions of interest defined around the carotid arteries. PCAT was categorized into three HU ranges: \u2212190 to \u2212120, \u2212119 to \u221270, and \u221269 to \u221230. Radiomics features were extracted using PyRadiomics. The primary outcome was the correlation of PCAT imaging with preoperative neutrophil-to-lymphocyte ratios (NLRs). The secondary outcome was the association of PCAT imaging with the red cell distribution width (RDW-CV). Linear regression was used to evaluate associations between PCAT characteristics and inflammatory markers. Results: Distinct HU ranges in PCAT imaging showed strong correlations with the preoperative NLR. The \u2212190 to \u2212120 HU range demonstrated a negative association (\u03b2 = \u22123.809, p &lt; 0.001), whereas the \u2212119 to \u221270 HU range showed a positive correlation (\u03b2 = 3.814, p &lt; 0.001). PCAT uniformity was positively associated with RDW-CV (\u03b2 = 0.494, p = 0.027). Other radiomics features, such as contrast, showed trends but did not reach statistical significance. A larger outer area of PCAT was inversely associated with the NLR (\u03b2 = \u22120.677, p &lt; 0.001). Conclusions: Specific PCAT HU ranges and radiomics features are significantly associated with systemic inflammatory markers in CEA patients. These findings suggest that HU-based segmentation and radiomics analysis of PCAT may offer valuable insights into the relationship between local adipose tissue characteristics and systemic inflammation.<\/jats:p>","DOI":"10.3390\/jcm14238342","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:31:34Z","timestamp":1764091894000},"page":"8342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Radiomics and Pericarotid Adipose Tissue Characteristics with Systemic Inflammation in Patients Undergoing Carotid Endarterectomy"],"prefix":"10.3390","volume":"14","author":[{"given":"Diogo","family":"Santos-Teixeira","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-429X","authenticated-orcid":false,"given":"Piotr","family":"Myrcha","sequence":"additional","affiliation":[{"name":"1st Chair and Department of General and Vascular Surgery, Faculty of Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Department of General, Vascular and Oncological Surgery, Masovian Brodnowski Hospital, 03-242 Warsaw, Poland"}]},{"given":"Vasco","family":"Trigo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Anatomy, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"RISE@Health, Departamento de Biomedicina, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monterio, 4200-319 Porto, Portugal"}]},{"given":"Hugo","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"RISE@Health, Departamento de Biomedicina, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monterio, 4200-319 Porto, Portugal"},{"name":"Community Palliative Care Support Team Gaia, 4400-129 Vila Nova de Gaia, Portugal"},{"name":"Departamento of Medicina da Comunidade, Informa\u00e7\u00e3o e Decis\u00e3o em Sa\u00fade, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Centre for Innovative Biomedicine and Biotechnology, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-816X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Barbosa-Breda","sequence":"additional","affiliation":[{"name":"RISE@Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Ophthalmology, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o, 4200-319 Porto, Portugal"},{"name":"Research Group Ophthalmology, Department of Neurosciences, KULeuven, 3000 Leuven, Belgium"}]},{"given":"Marina","family":"Dias-Neto","sequence":"additional","affiliation":[{"name":"Angiology and Vascular Surgery, Unidade Local de Sa\u00fade de S\u00e3o Jo\u00e3o, 4200-319 Porto, Portugal"},{"name":"Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-8935","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rocha-Neves","sequence":"additional","affiliation":[{"name":"RISE@Health, Departamento de Biomedicina, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monterio, 4200-319 Porto, Portugal"},{"name":"Angiology and Vascular Surgery, Unidade Local de Sa\u00fade de S\u00e3o Jo\u00e3o, 4200-319 Porto, Portugal"},{"name":"Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Department of Vascular Surgery, Unidade Local de Sa\u00fade do Alto Ave, EPE, 4835-044 Guimar\u00e3es, Portugal"}]},{"given":"Peter","family":"Gloviczki","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Gonda Vascular Center, Mayo Clinic, Rochester, MN 55901, USA"},{"name":"Faculty of Medicine, Semmelweis University, 1085 Budapest, Hungary"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, Y., Qin, Z., Wang, Y., Li, X., Zheng, Y., and Liu, Y. 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