{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:33:06Z","timestamp":1760239986625,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13SDG17080033"],"award-info":[{"award-number":["13SDG17080033"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG028740","R01AG056769"],"award-info":[{"award-number":["P30AG028740","R01AG056769"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006937","name":"National Center for Medical Rehabilitation Research","doi-asserted-by":"publisher","award":["P2CHD086851, T32HD071866"],"award-info":[{"award-number":["P2CHD086851, T32HD071866"]}],"id":[{"id":"10.13039\/100006937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This pilot randomized controlled trial (RCT) was designed to provide the preliminary data necessary to conduct a full-scale trial to compare the efficacy of differing first-line antihypertensive medications in improving functional status in older adults, when combined with exercise. The primary objectives were to assess study feasibility, safety, and protocol integrity. Dependent outcomes included gait speed, exercise capacity, body composition, and systemic cardiometabolic biomarkers. Thirty-one physically inactive older adults (70.6 \u00b1 6.1 years) with hypertension and functional limitations were randomly assigned to (1) Perindopril (8 mg\/day n = 10), (2) Losartan (100 mg\/day; n = 13), or (3) Hydrochlorothiazide (HCTZ: 25 mg\/day; n = 8). Participants were also assigned to a 24-week multimodal exercise intervention, separated into an aerobic and concurrent (aerobic + resistance) phase to evaluate potential mode effects. Retention was 84% (26\/31), and compliance was &gt;90% and &gt;79% with medication and exercise, respectively. A total of 29 adverse events (Perindopril = 5; Losartan = 12; HCTZ = 11) and one unrelated serious adverse event were observed throughout the trial. Overall, this pilot RCT provided critical data and identified several challenges to ultimately designing and implementing a fully powered trial.<\/jats:p>","DOI":"10.3390\/jcm8020196","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T11:51:12Z","timestamp":1549453872000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-1839","authenticated-orcid":false,"given":"Liliana C.","family":"Baptista","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35205, USA"},{"name":"Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-2299","authenticated-orcid":false,"given":"Byron C.","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}]},{"given":"Stephen D.","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, College of Medicine, Division of Clinical Research, University of Florida, Gainesville, FL 32610, USA"}]},{"given":"Anthony A.","family":"Bavry","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, FL 32610, USA"},{"name":"North Florida\/South Georgia Veterans Health System, Gainesville, FL 32608, USA"}]},{"given":"Eileen M.","family":"Handberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, FL 32610, USA"}]},{"given":"Anna K.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, College of Medicine, Division of Clinical Research, University of Florida, Gainesville, FL 32610, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-179X","authenticated-orcid":false,"given":"Sara A.","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35205, USA"},{"name":"Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}]},{"given":"Lisa M.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35205, USA"},{"name":"Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}]},{"given":"Bhanuprasad","family":"Sandesara","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, College of Medicine, Division of Clinical Research, University of Florida, Gainesville, FL 32610, USA"}]},{"given":"Christy S.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35205, USA"},{"name":"Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}]},{"given":"Thomas W.","family":"Buford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35205, USA"},{"name":"Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1016\/j.archger.2010.11.011","article-title":"Independence of elderly patients with arterial hypertension in fulfilling their needs, in the aspect of functional assessment and quality of life (QoL)","volume":"52","author":"Muszalik","year":"2011","journal-title":"Arch. 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