{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:50:59Z","timestamp":1778028659389,"version":"3.51.4"},"reference-count":203,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.<\/jats:p>","DOI":"10.3390\/jcm9030746","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T12:22:51Z","timestamp":1584015771000},"page":"746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-9797","authenticated-orcid":false,"given":"Bahare","family":"Salehi","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-2724","authenticated-orcid":false,"given":"Mar\u00eda L.","family":"Del Prado-Audelo","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Circuito Exterior S\/N, Del. Coyoac\u00e1n, Mexico City 04510, Mexico"},{"name":"Laboratorio de Posgrado en Tecnolog\u00eda Farmac\u00e9utica, FES-Cuautitl\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuautitl\u00e1n Izcalli 54740, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-4109","authenticated-orcid":false,"given":"Hern\u00e1n","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Departamento de Gen\u00e9tica, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-1100","authenticated-orcid":false,"given":"Gerardo","family":"Leyva-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Circuito Exterior S\/N, Del. Coyoac\u00e1n, Mexico City 04510, Mexico"}]},{"given":"Zorica","family":"Stojanovi\u0107-Radi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biology and Ecology, Faculty of Science and Mathematics, University of Ni\u0161, 18000 Ni\u0161, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-2345","authenticated-orcid":false,"given":"Yengkhom Disco","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Post-Harvest Technology, College of Horticulture and Forestry, Central Agricultural University, Pasighat 791102, Arunachal Pradesh, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-4355","authenticated-orcid":false,"given":"Jayanta Kumar","family":"Patra","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology &amp; Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, Korea"}]},{"given":"Gitishree","family":"Das","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology &amp; Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, Korea"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile"},{"name":"Unidad de Desarrollo Tecnol\u00f3gico, Universidad de Concepci\u00f3n UDT, Concepcion 4070386, Chile"}]},{"given":"Marzieh","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Research Department of Agronomy and Plant Breeding, Agricultural Research Institute, University of Zabol, Zabol 3585698613, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1517\/14728222.10.1.87","article-title":"From traditional Ayurvedic medicine to modern medicine: Identification of therapeutic targets for suppression of inflammation and cancer","volume":"10","author":"Aggarwal","year":"2006","journal-title":"Expert Opin. 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