{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T01:25:17Z","timestamp":1775525117406,"version":"3.50.1"},"reference-count":121,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Among the major neurodegenerative disorders (NDDs), Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.<\/jats:p>","DOI":"10.3390\/jcm9041061","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T03:40:19Z","timestamp":1586403619000},"page":"1061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":219,"title":["Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics"],"prefix":"10.3390","volume":"9","author":[{"given":"Mehdi","family":"Sharifi-Rad","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran"}]},{"given":"Chintha","family":"Lankatillake","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, PO Box 71, VIC 3083, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-3178","authenticated-orcid":false,"given":"Daniel A.","family":"Dias","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, PO Box 71, VIC 3083, Australia"}]},{"given":"Anca Oana","family":"Docea","sequence":"additional","affiliation":[{"name":"Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-8666","authenticated-orcid":false,"given":"Mohamad Fawzi","family":"Mahomoodally","sequence":"additional","affiliation":[{"name":"Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam"},{"name":"Department of Health Sciences, Faculty of Science, University of Mauritius, R\u00e9duit 80837, Mauritius"}]},{"given":"Devina","family":"Lobine","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Science, University of Mauritius, R\u00e9duit 80837, Mauritius"}]},{"given":"Paul L.","family":"Chazot","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Durham University, Durham DH1 3LE, UK"}]},{"given":"Begum","family":"Kurt","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, Canakkale 17020, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-4867","authenticated-orcid":false,"given":"Tugba","family":"Boyunegmez Tumer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Science, Canakkale Onsekiz Mart University, Canakkale 17020, Turkey"}]},{"given":"Ana","family":"Catarina Moreira","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Hospital Garcia de Orta, EPE Almada, 2801-951 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-8887","authenticated-orcid":false,"given":"Farukh","family":"Sharopov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, Dushanbe 734003, Tajikistan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-7623","authenticated-orcid":false,"given":"Miquel","family":"Martorell","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile"},{"name":"Universidad de Concepci\u00f3n, Unidad de Desarrollo Tecnol\u00f3gico, UDT, Concepcion 4070386, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-5201","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-9116","authenticated-orcid":false,"given":"Daniela","family":"Calina","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a028035","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","volume":"9","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb. 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