{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:46:11Z","timestamp":1760147171145,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Clinical and Biomedical Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Compos. Sci."],"abstract":"<jats:p>This study aimed to evaluate and compare the microleakage of composite resin restorations under a total-etch adhesive system applied with two different techniques, with and without cure. Cavities were made on the buccal surface of twenty-six intact teeth and subsequently restored with bulk-fill flow composite resin (SDR\u00ae\u00ae flow+) and conventional resin (Spectra\u2122 ST HV). Two experimental groups were created, one where the total-etch adhesive (Prime &amp; Bond Active\u00ae) was cured and another where the adhesive was not cured before placing the flowable resin. Two control groups were also created, negative and positive. After the restorations were finished the, teeth were submerged in a solution of sodium pertechnetate (99mTcNaO4) for 3 h to evaluate the microleakage. The results showed more infiltration of radioisotopes characterized by the highest total count values of microleakage in group 1 (cured adhesive) and in the positive control. Group 2 (noncured adhesive) and the negative control showed lower values. We therefore considered that these groups were similar since their p-value was less than 0.05, with no statistically significant difference. Group 4 showed a statistically significant increase in relation to group 3 (p = 0.027). We concluded that the method of bulk-fill composite resins with noncured adhesive agents can have a positive effect on the longevity of bond strengths, with reduced microleakage.<\/jats:p>","DOI":"10.3390\/jcs7010040","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:29:57Z","timestamp":1673576997000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microleakage Study of a Bulk Fill over an Uncured Adhesive System"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-7125","authenticated-orcid":false,"given":"Mariana Vaz","family":"Pinto","sequence":"first","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Salom\u00e9","family":"Pires","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-5417","authenticated-orcid":false,"given":"Carlos Miguel","family":"Marto","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"},{"name":"Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"}]},{"given":"In\u00eas","family":"Amaro","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-7926","authenticated-orcid":false,"given":"Ana","family":"Coelho","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"given":"Jos\u00e9","family":"Sousa","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"}]},{"given":"Manuel Marques","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"},{"name":"Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-5557","authenticated-orcid":false,"given":"Eunice","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-7871","authenticated-orcid":false,"given":"Ana Margarida","family":"Abrantes","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-4173","authenticated-orcid":false,"given":"Anabela Baptista","family":"Paula","sequence":"additional","affiliation":[{"name":"Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.dental.2017.11.005","article-title":"Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications","volume":"34","author":"Breschi","year":"2018","journal-title":"Dent. 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