{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:36:30Z","timestamp":1775165790145,"version":"3.50.1"},"reference-count":90,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04585\/2020"],"award-info":[{"award-number":["UIDB\/04585\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Subsurface enamel demineralization beneath an intact surface layer or white spots lesions (WSL) can and should be treated with non-invasive procedures to impede the development of a cavitated lesion. We aim to analyze if infiltrative resin improves enamel roughness, microhardness, shear bond strength, and penetration depth. MEDLINE [via Pubmed], Cochrane Central Register of Controlled Trials, Embase, Web of Science, Scholar, and LILACS were searched until May 2021. Methodological quality was assessed using the Joanna Briggs Institute Clinical Appraisal Checklist for Experimental Studies. Pairwise ratio of means (ROM) meta-analyses were carried out to compare the enamel properties after treatment with infiltrative resin on sound enamel and WSLs. From a total of 1604 articles, 48 studies were included. Enamel surface roughness decreased 35% in sound enamel (95%CI: 0.49\u20130.85, I2 = 98.2%) and 54% in WSLs (95%CI: 0.29\u20130.74, I2 = 98.5%). Microhardness reduced 24% in sound enamel (95%CI: 0.73\u20130.80, I2 = 99.1%) and increased by 68% in WSLs (95%CI: 1.51; 1.86, I2 = 99.8%). Shear bond strength reduced of 25% in sound enamel (95%CI: 0.60; 0.95, I2 = 96.9%) and increased by 89% in WSLs (95%CI: 1.28\u20132.79, I2 = 99.8%). Penetration depth was 65.39% of the WSLs (95%CI: 56.11\u201374.66, I2 = 100%). Infiltrative resins effectively promote evident changes in enamel properties in sound and WSLs. Future studies with long-term follow-ups are necessary to corroborate these results from experimental studies.<\/jats:p>","DOI":"10.3390\/jfb12030048","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T21:28:04Z","timestamp":1629149284000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effect of Resin Infiltration on Enamel: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Madalena","family":"Soveral","sequence":"first","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-260X","authenticated-orcid":false,"given":"Vanessa","family":"Machado","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"},{"name":"Evidence-Based Hub, Clinical Research Unit, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1019-8263","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Botelho","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"},{"name":"Evidence-Based Hub, Clinical Research Unit, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4077","authenticated-orcid":false,"given":"Jos\u00e9 Jo\u00e3o","family":"Mendes","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"}]},{"given":"Cristina","family":"Manso","sequence":"additional","affiliation":[{"name":"Clinical Research Unit (CRU), Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Egas Moniz\u2014Cooperativa de Ensino Superior, CRL, 2829-511 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dorri, M., Martinez-Zapata, M.J., Walsh, T., Marinho, V.C., Sheiham deceased, A., and Zaror, C. (2017). Atraumatic Restorative Treatment versus Conventional Restorative Treatment for Managing Dental Caries. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD008072.pub2"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global Burden of Untreated Caries: A Systematic Review and Metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1053\/j.sodo.2008.03.002","article-title":"White Spot Lesions: Formation, Prevention, and Treatment","volume":"14","author":"Bishara","year":"2008","journal-title":"Semin. Orthod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/jerd.12013","article-title":"A Contemporary Review of White Spot Lesions in Orthodontics: White Spot Lesions in Orthodontics","volume":"25","author":"Heymann","year":"2013","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2319\/071712-584.1","article-title":"Prevalence of White Spot Lesion Formation during Orthodontic Treatment","volume":"83","author":"Julien","year":"2013","journal-title":"Angle Orthod."},{"key":"ref_6","first-page":"2","article-title":"Iatrogenic Effects of Orthodontic Treatment\u2014Review on White Spot Lesions","volume":"2","author":"Sangamesh","year":"2011","journal-title":"Int. J. Sci. Eng. Res."},{"key":"ref_7","unstructured":"Black, G.V. (1908). Operative Dentistry: The Pathology of the Hard Tissues of the Teeth, Medico-Dnetal Publishing. [1st ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0002-9416(82)90032-X","article-title":"Incidence of White Spot Formation after Bonding and Banding","volume":"81","author":"Gorelick","year":"1982","journal-title":"Am. J. Orthod."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2319\/051710-262.1","article-title":"Prevalence of White Spot Lesions during Orthodontic Treatment with Fixed Appliances","volume":"81","author":"Tufekci","year":"2011","journal-title":"Angle Orthod."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"(2021, June 12). Prevalence of White-Spot Lesions before and during Orthodontic Treatment with Fixed Appliances | European Journal of Orthodontics | Oxford Academic. Available online: https:\/\/academic.oup.com\/ejo\/article\/35\/5\/664\/495801.","DOI":"10.1093\/ejo\/cjs070"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/2231-0762.167719","article-title":"Critical Evaluation of Incidence and Prevalence of White Spot Lesions during Fixed Orthodontic Appliance Treatment: A Meta-Analysis","volume":"5","author":"Sundararaj","year":"2015","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/0022034518800014","article-title":"Nonrestorative Treatments for Caries: Systematic Review and Network Meta-Analysis","volume":"98","author":"Urquhart","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0972-0707.92613","article-title":"Tooth Fragment Reattachment Technique on a Pluri Traumatized Tooth","volume":"15","author":"Giudice","year":"2012","journal-title":"J. Conserv. Dent. JCD"},{"key":"ref_14","first-page":"107","article-title":"Restorative Treatment Decisions in Posterior Teeth: A Systematic Review","volume":"15","author":"Henz","year":"2017","journal-title":"Oral Health Prev. Dent."},{"key":"ref_15","first-page":"197","article-title":"Minimally Invasive Treatment of White Spot Lesions\u2014A Systematic Review","volume":"14","author":"Abdullah","year":"2016","journal-title":"Oral Health Prev. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/JISPPD.JISPPD_187_16","article-title":"Assessment of Maternal Risk Factors and Its Relationship with Early Childhood Caries among Preschool Children in Mangaluru City","volume":"35","author":"Bhat","year":"2017","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000371709","article-title":"Resin Infiltration of Non-Cavitated Caries Lesions: A Systematic Review","volume":"24","author":"Ducamp","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000099323","article-title":"Surface Layer Erosion of Natural Caries Lesions with Phosphoric and Hydrochloric Acid Gels in Preparation for Resin Infiltration","volume":"41","author":"Paris","year":"2007","journal-title":"Caries Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Dorri, M., Dunne, S.M., Walsh, T., and Schwendicke, F. (2015). Micro-Invasive Interventions for Managing Proximal Dental Decay in Primary and Permanent Teeth. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD010431.pub2"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101405","DOI":"10.1016\/j.jebdp.2020.101405","article-title":"Effect of Resin Infiltration Technique on Improving Surface Hardness of Enamel Lesions: A Systematic Review and Meta-Analysis","volume":"20","author":"Zakizade","year":"2020","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jdent.2016.10.010","article-title":"Is Resin Infiltration an Effective Esthetic Treatment for Enamel Development Defects and White Spot Lesions? A Systematic Review","volume":"56","author":"Borges","year":"2017","journal-title":"J. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/iej.12410","article-title":"Master Apical File Size\u2014Smaller or Larger: A Systematic Review of Microbial Reduction","volume":"48","author":"Aminoshariae","year":"2015","journal-title":"Int. Endod. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00784-020-03690-x","article-title":"Comparison between Immediate and Delayed Post Space Preparations: A Systematic Review and Meta-Analysis","volume":"25","author":"Abreu","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.joen.2015.06.006","article-title":"Ultrasonically Activated Irrigation to Remove Calcium Hydroxide from Apical Third of Human Root Canal System: A Systematic Review of In Vitro Studies","volume":"41","author":"Kececi","year":"2015","journal-title":"J. Endod."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hozo, S.P., Djulbegovic, B., and Hozo, I. (2005). Estimating the Mean and Variance from the Median, Range, and the Size of a Sample. BMC Med. Res. Methodol., 5.","DOI":"10.1186\/1471-2288-5-13"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s Tool for Assessing Risk of Bias in Randomised Trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.21608\/ajdsm.2020.71479","article-title":"The Effect of Caries Infiltration Technique (Icons) on Surface Roughness and Microhardness of Enamel White Spot Lesions","volume":"21","author":"Atta","year":"2018","journal-title":"Al-Azhar J. Dent. Sci."},{"key":"ref_28","first-page":"3735","article-title":"Microhardness, sem and color change analysis of artificial enamel lesions in primary teeth treated with resin infiltration, cpp-acp or fluoride gel: An in vitro study","volume":"62","author":"Metwalli","year":"2016","journal-title":"Egypt. Dent. J."},{"key":"ref_29","first-page":"120","article-title":"Effects of Resin Application on White Spot Lesions (Laboratory Study)","volume":"46","author":"Abdellatif","year":"2016","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_30","first-page":"784","article-title":"Novel Hydroxyapatite Nanorods Improve Anti-Caries Efficacy of Enamel Infiltrants","volume":"32","author":"Carvalho","year":"2016","journal-title":"Dent. Mater. Off. Publ. Acad. Dent. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4012\/dmj.2014-078","article-title":"Effect of Resin Infiltration on Enamel Surface Properties and Streptococcus Mutans Adhesion to Artificial Enamel Lesions","volume":"34","author":"Arslan","year":"2015","journal-title":"Dent. Mater. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2319\/012311-48.1","article-title":"Shear Bond Strength of Brackets to Demineralize Enamel after Different Pretreatment Methods","volume":"82","author":"Attin","year":"2012","journal-title":"Angle Orthod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.21608\/edj.2020.38417.1202","article-title":"Effect of Remineralizing Agents and Resin Infiltration on Resistance to Demineralization of Artificial Enamel Lesions","volume":"66","author":"Ayad","year":"2020","journal-title":"Egypt. Dent. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.19082\/3934","article-title":"Comparison of the Effect of Resin Infiltrant, Fluoride Varnish, and Nano-Hydroxy Apatite Paste on Surface Hardness and Streptococcus Mutans Adhesion to Artificial Enamel Lesions","volume":"9","author":"Aziznezhad","year":"2017","journal-title":"Electron. Physician"},{"key":"ref_35","first-page":"12","article-title":"Effect of Two Methods of Remineralization and Resin Infiltration on Surface Hardness of Artificially Induced Enamel Lesions","volume":"21","author":"Behrouzi","year":"2020","journal-title":"J. Dent. Shiraz Iran"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jds.2020.04.005","article-title":"Effect of Resin Infiltration Application on Early Proximal Caries Lesions in Vitro","volume":"16","author":"Alamoudi","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.21608\/edj.2018.77339","article-title":"Surface properties of resin-infiltrated incipient enamel lesions after aging under thermal stresses","volume":"64","author":"Enan","year":"2018","journal-title":"Egypt. Dent. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jerd.12279","article-title":"Evaluation of Surface Roughness Characteristics Using Atomic Force Microscopy and Inspection of Microhardness Following Resin Infiltration with Icon\u00ae","volume":"29","author":"Gurdogan","year":"2017","journal-title":"J. Esthet. Restor. Dent. Off. Publ. Am. Acad. Esthet. Dent. Al"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/jerd.12308","article-title":"Effect of Resin Infiltration on the Color and Microhardness of Bleached White-Spot Lesions in Bovine Enamel (an in vitro Study)","volume":"29","author":"Horuztepe","year":"2017","journal-title":"J. Esthet. Restor. Dent. Off. Publ. Am. Acad. Esthet. Dent. Al"},{"key":"ref_40","first-page":"ZC142","article-title":"Microhardness and Penetration of Artificial White Spot Lesions Treated with Resin or Colloidal Silica Infiltration","volume":"11","author":"Mandava","year":"2017","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40510-015-0080-2","article-title":"In Vitro Study of the Potential Protection of Sound Enamel against Demineralization","volume":"16","author":"Montasser","year":"2015","journal-title":"Prog. Orthod."},{"key":"ref_42","first-page":"94","article-title":"Study regarding the assessment of enamel microhardness in incipient carious lesions treated by icon method","volume":"3","author":"Pancu","year":"2011","journal-title":"Rom. J. Oral Rehabil."},{"key":"ref_43","unstructured":"Paris, S. (2021, March 10). Micro-Hardness and Mineral Loss of Enamel Lesions after Infiltration with Various Resins: Influence of Infiltrant Composition and Application Frequency in Vitro\u2014ScienceDirect. Available online: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0300571213000869."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5005\/jp-journals-10005-1445","article-title":"Effect of Resin Infiltration on Artificial Caries: An in Vitro Evaluation of Resin Penetration and Microhardness","volume":"10","author":"Prajapati","year":"2017","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_45","first-page":"1","article-title":"Assessement of White Spot Treated with (ICON) and Flouride Gel (An In Vitro Study)","volume":"3","author":"Qasim","year":"2014","journal-title":"Int. J. Enhanc. Res. Sci. Technol. Eng."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.21608\/adjalexu.2016.59167","article-title":"Penetration depth and enamel microhardness of resin infiltrant and traditional techniques for treatment of artificial enamel lesions","volume":"41","year":"2016","journal-title":"Alex. Dent. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.sdentj.2011.10.003","article-title":"The Influence of Resin Infiltration System on Enamel Microhardness and Surface Roughness: An in Vitro Study","volume":"24","author":"Taher","year":"2012","journal-title":"Saudi Dent. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2341\/11-070-L","article-title":"Effect of Caries Infiltration Technique and Fluoride Therapy on Microhardness of Enamel Carious Lesions","volume":"37","author":"Torres","year":"2012","journal-title":"Oper. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/00016357.2018.1437217","article-title":"Effect of Resin Infiltration and Microabrasion on the Microhardness, Surface Roughness and Morphology of Incipient Carious Lesions","volume":"76","author":"Yazkan","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4103\/1319-2442.261345","article-title":"An In-Vitro Evaluation of Resin Infiltration System and Conventional Pit and Fissure Sealant on Enamel Properties in White Spot Lesions","volume":"37","author":"Arora","year":"2019","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.5005\/jp-journals-10005-1692","article-title":"Resin Infiltration of Artificial Enamel Lesions: Evaluation of Penetration Depth, Surface Roughness and Color Stability","volume":"12","author":"Aswani","year":"2019","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2319\/041515-247.1","article-title":"Effects of Remineralization Procedures on Shear Bond Strengths of Brackets Bonded to Demineralized Enamel Surfaces with Self-Etch Systems","volume":"86","author":"Baka","year":"2016","journal-title":"Angle Orthod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/jerd.12471","article-title":"Resistance of Resin-Infiltrated Enamel to Surface Changes in Response to Acidic Challenge","volume":"31","author":"Enan","year":"2019","journal-title":"J. Esthet. Restor. Dent. Off. Publ. Am. Acad. Esthet. Dent. Al"},{"key":"ref_54","first-page":"95","article-title":"Differences in Enamel Surface Roughness Changes after Debonding Using Resin Infiltration System and Nano-Filled Resin Coating","volume":"12","author":"Khalid","year":"2019","journal-title":"J. Int. Dent. Med. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jdent.2018.03.010","article-title":"Modified Resin Infiltration of Non-, Micro- and Cavitated Proximal Caries Lesions in Vitro","volume":"74","author":"Askar","year":"2018","journal-title":"J. Dent."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2341\/13-202-L","article-title":"In Vitro Progression of Artificial White Spot Lesions Sealed with an Infiltrant Resin","volume":"39","author":"Gelani","year":"2014","journal-title":"Oper. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000366082","article-title":"Resin Infiltration of Fissure Caries with Various Techniques of Pretreatment in Vitro","volume":"49","author":"Lausch","year":"2015","journal-title":"Caries Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1590\/0103-6440201902329","article-title":"Effect of Conditioning Protocols and Ultrasonic Application of an Infiltrant Resin in White Spot Lesions","volume":"30","author":"Dominguez","year":"2019","journal-title":"Braz. Dent. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jdent.2011.04.003","article-title":"Influence of Application Time on Penetration of an Infiltrant into Natural Enamel Caries","volume":"39","author":"Chatzidakis","year":"2011","journal-title":"J. Dent."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jdent.2015.03.006","article-title":"Evaluation of Penetration Effect of Resin Infiltrant Using Optical Coherence Tomography","volume":"43","author":"Min","year":"2015","journal-title":"J. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00784-012-0909-8","article-title":"Pretreatment of Natural Caries Lesions Affects Penetration Depth of Infiltrants in Vitro","volume":"17","author":"Paris","year":"2013","journal-title":"Clin. Oral Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1600-0722.2011.00807.x","article-title":"Resin Infiltration of Proximal Caries Lesions Differing in ICDAS Codes","volume":"119","author":"Paris","year":"2011","journal-title":"Eur. J. Oral Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jdent.2014.01.006","article-title":"Comparison of Sealant and Infiltrant Penetration into Pit and Fissure Caries Lesions in Vitro","volume":"42","author":"Paris","year":"2014","journal-title":"J. Dent."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-263X.2011.01204.x","article-title":"Penetration Depths of an Infiltrant into Proximal Caries Lesions in Primary Molars after Different Application Times in Vitro","volume":"22","author":"Paris","year":"2011","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.37358\/RC.17.11.5934","article-title":"Low Viscosity Resin Penetration Degree in Incipient Caries Lesions","volume":"68","author":"Podariu","year":"2017","journal-title":"Rev. Chim."},{"key":"ref_66","first-page":"265","article-title":"Masking and Penetration Ability of Various Sealants and ICON in Artificial Initial Caries Lesions In Vitro","volume":"21","author":"Theodory","year":"2019","journal-title":"J. Adhes. Dent."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"104146","DOI":"10.1016\/j.jmbbm.2020.104146","article-title":"Experimental Self-Etching Resin Infiltrants on the Treatment of Simulated Carious White Spot Lesions","volume":"113","author":"Wang","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.12688\/f1000research.20523.1","article-title":"Adhesive Systems Effect over Bond Strength of Resin-Infiltrated and de\/Remineralized Enamel","volume":"8","author":"Borges","year":"2019","journal-title":"F1000Research"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jopr.12230","article-title":"Effects of Different Demineralization-Inhibiting Methods on the Shear Bond Strength of Glass-Ceramics","volume":"24","author":"Dilber","year":"2015","journal-title":"J. Prosthodont. Off. J. Am. Coll. Prosthodont."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4041\/kjod.2012.42.1.17","article-title":"Effects of Demineralizaton-Inhibition Procedures on the Bond Strength of Brackets Bonded to Demineralized Enamel Surface","volume":"42","author":"Ekizer","year":"2012","journal-title":"Korean J. Orthod."},{"key":"ref_71","unstructured":"Gulec, A. (2021, March 11). Assessment of the Resin Infiltration and CPP-ACP Applications before Orthodontic Brackets Bonding\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/31434834\/."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00016357.2014.982703","article-title":"Effects of Different Pre-Treatment Methods on the Shear Bond Strength of Orthodontic Brackets to Demineralized Enamel","volume":"74","author":"Akin","year":"2016","journal-title":"Acta Odontol. Scand."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/2177-6709.21.2.039-044.oar","article-title":"Bonding Brackets on White Spot Lesions Pretreated by Means of Two Methods","volume":"21","author":"Vianna","year":"2016","journal-title":"Dent. Press J. Orthod."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1016\/j.jdent.2013.04.003","article-title":"Masking of White Spot Lesions by Resin Infiltration in Vitro","volume":"41","author":"Paris","year":"2013","journal-title":"J. Dent."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Perdig\u00e3o, J. (2016). Resin Infiltration after Enamel Etching. Tooth Whitening, Springer International Publishing.","DOI":"10.1007\/978-3-319-38849-6"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.sdentj.2017.12.001","article-title":"In Vitro Study of White Spot Lesion: Maxilla and Mandibular Teeth","volume":"30","author":"Mohamed","year":"2018","journal-title":"Saudi Dent. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.21608\/edj.2018.77340","article-title":"Effect of PH Challenge on the Micro-Hardness of Artificially Induced de-Mineralized Enamel Treated with Resin Infiltrant and Fluoride Varnish","volume":"64","author":"Attia","year":"2018","journal-title":"Egypt. Dent. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.yapd.2017.03.011","article-title":"Dental Caries","volume":"64","author":"Wong","year":"2017","journal-title":"Adv. Pediatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.2147\/IJN.S107624","article-title":"Demineralization\u2013Remineralization Dynamics in Teeth and Bone","volume":"11","author":"Aljabo","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/10454411910020030101","article-title":"Mechanistic Aspects of the Interactions Between Fluoride and Dental Enamel","volume":"2","author":"Featherstone","year":"1991","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2341\/16-144-L","article-title":"Microhardness and Roughness of Infiltrated White Spot Lesions Submitted to Different Challenges","volume":"42","author":"Neres","year":"2017","journal-title":"Oper. Dent."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0143-7496(95)00029-1","article-title":"Analysis of Dental Shear Bond Strength Tests, Shear or Tensile?","volume":"16","author":"Rasmussen","year":"1996","journal-title":"Int. J. Adhes. Adhes."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1708-8240.1991.tb00985.x","article-title":"Hybrid Layer as a Dentin-Bonding Mechanism","volume":"3","author":"Nakabayashi","year":"1991","journal-title":"J. Esthet. Dent."},{"key":"ref_84","first-page":"317","article-title":"Resin Infiltration of Enamel White Spot Lesions: An Ultramorphological Analysis","volume":"32","year":"2020","journal-title":"J. Esthet. Restor. Dent. Off. Publ. Am. Acad. Esthet. Dent. Al"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2334\/josnusd.53.273","article-title":"Bovine Teeth as Substitute for Human Teeth in Dental Research: A Review of Literature","volume":"53","author":"Yassen","year":"2011","journal-title":"J. Oral Sci."},{"key":"ref_86","first-page":"161","article-title":"Crystallites Dimensions of Enamel","volume":"6","author":"Arends","year":"1978","journal-title":"J. Biol. Buccale"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1177\/002203459207100S25","article-title":"Hard-Tissue Substrates for Evaluation of Cariogenic and Anti-Cariogenic Activity in Situ","volume":"71","author":"Mellberg","year":"1992","journal-title":"J. Dent. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/0003-9969(69)90258-1","article-title":"The Characterization of Enamel Surface Demineralization, Remineralization, and Associated Hardness Changes in Human and Bovine Material","volume":"14","author":"Feagin","year":"1969","journal-title":"Arch. Oral Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000072165","article-title":"Caries Progression and Inhibition in Human and Bovine Root Dentine in Situ","volume":"37","author":"Hara","year":"2003","journal-title":"Caries Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"R\u00fcttermann, S., Braun, A., and Janda, R. (2013). Shear Bond Strength and Fracture Analysis of Human vs. Bovine Teeth. 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