{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:38:13Z","timestamp":1778701093907,"version":"3.51.4"},"reference-count":174,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Polydimethylsiloxane (PDMS) is an elastomer with excellent optical, electrical and mechanical properties, which makes it well-suited for several engineering applications. Due to its biocompatibility, PDMS is widely used for biomedical purposes. This widespread use has also led to the massification of the soft-lithography technique, introduced for facilitating the rapid prototyping of micro and nanostructures using elastomeric materials, most notably PDMS. This technique has allowed advances in microfluidic, electronic and biomedical fields. In this review, an overview of the properties of PDMS and some of its commonly used treatments, aiming at the suitability to those fields\u2019 needs, are presented. Applications such as microchips in the biomedical field, replication of cardiovascular flow and medical implants are also reviewed.<\/jats:p>","DOI":"10.3390\/jfb13010002","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T09:50:43Z","timestamp":1640080243000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":691,"title":["Properties and Applications of PDMS for Biomedical Engineering: A Review"],"prefix":"10.3390","volume":"13","author":[{"given":"In\u00eas","family":"Miranda","sequence":"first","affiliation":[{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimaraes, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-073X","authenticated-orcid":false,"given":"Andrews","family":"Souza","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimaraes, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-808X","authenticated-orcid":false,"given":"Paulo","family":"Sousa","sequence":"additional","affiliation":[{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimaraes, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-148X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Campus de Santa Apol\u00f3nia, Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-253 Braganca, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5829-6081","authenticated-orcid":false,"given":"Elisabete M. S.","family":"Castanheira","sequence":"additional","affiliation":[{"name":"Centre of Physics of Minho and Porto Universities (CF-UM-UP), Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-637X","authenticated-orcid":false,"given":"Rui","family":"Lima","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimaraes, Portugal"},{"name":"CEFT, Faculdade de Engenharia da Universidade do Porto (FEUP), Rua Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-0556","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Minas","sequence":"additional","affiliation":[{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimaraes, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1002\/anie.200702286","article-title":"A Self-assembly approach to chemical micropatterning of Poly(dimethylsiloxane)","volume":"46","author":"Poll","year":"2007","journal-title":"Angew. 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