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Here, we report a method to fabricate electrospun drug-loaded organic\/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT\/DOX\/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT\/DOX\/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT\/DOX\/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT\/DOX\/PLGA nanofibers, the designed organic\u2013inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications.<\/jats:p>","DOI":"10.3390\/jfb13020055","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:31:55Z","timestamp":1652171515000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite\u2013Poly(lactic-co-glycolic acid) Composite Nanofibers"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhe","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, China"},{"name":"Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5187-0450","authenticated-orcid":false,"given":"Yili","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}]},{"given":"Mingwu","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-2041","authenticated-orcid":false,"given":"Helena","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-7591","authenticated-orcid":false,"given":"Benqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-6645","authenticated-orcid":false,"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China"},{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1002\/anie.200604646","article-title":"Electrospinning: A fascinating method for the preparation of ultrathin fibers","volume":"46","author":"Greiner","year":"2007","journal-title":"Angew. 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