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Group\/UM)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["\u201cTERM RES Hub \u2013 Scientific Infrastructure for Tissue Engineering and Regenerative Medicine\u201d, reference PINFRA\/22190\/2016 (Norte-01-0145-FEDER-022190)"],"award-info":[{"award-number":["\u201cTERM RES Hub \u2013 Scientific Infrastructure for Tissue Engineering and Regenerative Medicine\u201d, reference PINFRA\/22190\/2016 (Norte-01-0145-FEDER-022190)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maria Sklodowska-Curie grant","award":["SHIFT Project (funded by the European Union\u2019s Horizon 2020 Research and Innovation programme under the Maria Sklodowska-Curie grant agreement no. 101008041)"],"award-info":[{"award-number":["SHIFT Project (funded by the European Union\u2019s Horizon 2020 Research and Innovation programme under the Maria Sklodowska-Curie grant agreement no. 101008041)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JFB"],"abstract":"<jats:p>Bone is a calcified tissue composed of 60% inorganic compounds, 30% organic compounds, and 10% water. Bone exhibits an intrinsic regenerative capacity, enabling it to heal after fractures or adapt during growth. However, in cases of severe injury or extensive tissue loss, this regenerative capacity becomes insufficient, often necessitating bone graft surgeries using autografts or allografts. Conventional grafting approaches present several limitations, driving the development of alternative strategies in tissue engineering. The system of hydrogel\u2013nanoparticles (NPs) represents a new class of biomaterials designed to combine the advantages of both materials while mitigating their drawbacks. This review focuses on a combination of nature-based hydrogels with different types of nanoparticles and discusses their potential applications in bone regeneration.<\/jats:p>","DOI":"10.3390\/jfb16090317","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:39:01Z","timestamp":1756744741000},"page":"317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nature-Based Hydrogels Combined with Nanoparticles for Bone Regeneration"],"prefix":"10.3390","volume":"16","author":[{"given":"Margarida","family":"Fernandes","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Rua Ave 1, Edif\u00edcio 1 (Sede), Barco, 4805-694 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019S\u2014PT Government Associate Laboratory, Braga, 4805-694 Guimar\u00e3es, Portugal"},{"name":"RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), ESS, Polytechnic of Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8687-4811","authenticated-orcid":false,"given":"M\u00f3nica","family":"Vieira","sequence":"additional","affiliation":[{"name":"RISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), ESS, Polytechnic of Porto, R. Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"given":"Daniela","family":"Peixoto","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Rua Ave 1, Edif\u00edcio 1 (Sede), Barco, 4805-694 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019S\u2014PT Government Associate Laboratory, Braga, 4805-694 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-4091","authenticated-orcid":false,"given":"Nat\u00e1lia M.","family":"Alves","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Rua Ave 1, Edif\u00edcio 1 (Sede), Barco, 4805-694 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019S\u2014PT Government Associate Laboratory, Braga, 4805-694 Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref_1","first-page":"189","article-title":"Chemical and Biochemical Basis of Cell-Bone Matrix Interaction in Health and Disease","volume":"3","author":"Feng","year":"2009","journal-title":"Curr. 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