{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:45:54Z","timestamp":1760233554640,"version":"build-2065373602"},"reference-count":88,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["480316\/2012-0"],"award-info":[{"award-number":["480316\/2012-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Apoio ao Desenvolvimento Cient\u00edfico (PADC)","award":["-"],"award-info":[{"award-number":["-"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/05853-1"],"award-info":[{"award-number":["2013\/05853-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Apoyo a Proyectos de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica-Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico (PAPIIT-DGAPA\/UNAM-MX)","award":["IN217418"],"award-info":[{"award-number":["IN217418"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Histoplasma capsulatum affects healthy and immunocompromised individuals, sometimes causing a severe disease. This fungus has two morphotypes, the mycelial (infective) and the yeast (parasitic) phases. MicroRNAs (miRNAs) are small RNAs involved in the regulation of several cellular processes, and their differential expression has been associated with many disease states. To investigate miRNA expression in host cells during H. capsulatum infection, we studied the changes in the miRNA profiles of differentiated human macrophages infected with yeasts from two fungal strains with different virulence, EH-315 (high virulence) and 60I (low virulence) grown in planktonic cultures, and EH-315 grown in biofilm form. MiRNA profiles were evaluated by means of reverse transcription-quantitative polymerase chain reaction using a commercial human miRNome panel. The target genes of the differentially expressed miRNAs and their corresponding signaling pathways were predicted using bioinformatics analyses. Here, we confirmed biofilm structures were present in the EH-315 culture whose conditions facilitated producing insoluble exopolysaccharide and intracellular polysaccharides. In infected macrophages, bioinformatics analyses revealed especially increased (hsa-miR-99b-3p) or decreased (hsa-miR-342-3p) miRNAs expression levels in response to infection with biofilms or both growth forms of H. capsulatum yeasts, respectively. The results of miRNAs suggested that infection by H. capsulatum can affect important biological pathways of the host cell, targeting two genes: one encoding a protein that is important in the cortical cytoskeleton; the other, a protein involved in the formation of stress granules. Expressed miRNAs in the host\u2019s response could be proposed as new therapeutic and\/or diagnostic tools for histoplasmosis.<\/jats:p>","DOI":"10.3390\/jof7010060","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T05:17:34Z","timestamp":1610947054000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential miRNA Expression in Human Macrophage-Like Cells Infected with Histoplasma capsulatum Yeasts Cultured in Planktonic and Biofilm Forms"],"prefix":"10.3390","volume":"7","author":[{"given":"Nayla de Souza","family":"Pitangui","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"},{"name":"Department of Cellular and Molecular Biology, Ribeir\u00e3o Preto School of Medicine, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14049-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-0657","authenticated-orcid":false,"given":"Junya","family":"de Lacorte Singulani","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}]},{"given":"Janaina de C\u00e1ssia Orlandi","family":"Sardi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul 79070-900, Brazil"}]},{"given":"Paula Carolina","family":"de Souza","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}]},{"given":"Gabriela","family":"Rodr\u00edguez-Arellanes","sequence":"additional","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, UNAM-Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}]},{"given":"Blanca Estela","family":"Garc\u00eda-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, IPN\u2013Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-8557","authenticated-orcid":false,"given":"Francisco Javier","family":"Enguita","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-3963","authenticated-orcid":false,"given":"Fernando R.","family":"Pavan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}]},{"given":"Maria Lucia","family":"Taylor","sequence":"additional","affiliation":[{"name":"Unidad de Micolog\u00eda, Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, UNAM-Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-0826","authenticated-orcid":false,"given":"Maria Jos\u00e9 Soares","family":"Mendes-Giannini","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}]},{"given":"Ana Marisa","family":"Fusco-Almeida","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1128\/JCM.37.5.1404-1408.1999","article-title":"Relatedness Analyses of Histoplasma capsulatum Isolates from Mexican Patients with AIDS-Associated Histoplasmosis by Using Histoplasmin Electrophoretic Profiles and Randomly Amplified Polymorphic DNA Patterns","volume":"37","author":"Valle","year":"1999","journal-title":"J. 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