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Understanding the molecular basis of azole resistance in C. glabrata is crucial to designing more suitable therapeutic strategies. In this study, the role of the transcription factor encoded by ORF CAGL0B03421g, here denominated as CgMar1 (Multiple Azole Resistance 1), in azole susceptibility was explored. Using RNA-sequencing, CgMar1 was found to regulate 337 genes under fluconazole stress, including several related to lipid biosynthesis pathways. In this context, CgMar1 and its target CgRSB1, encoding a predicted sphingoid long-chain base efflux transporter, were found to contribute to plasma membrane sphingolipid incorporation and membrane permeability, decreasing fluconazole accumulation. CgMar1 was found to associate with the promoter of CgRSB1, which contains two instances of the CCCCTCC consensus, found to be required for CgRSB1 activation during fluconazole stress. Altogether, a regulatory pathway modulating azole susceptibility in C. glabrata is proposed, resulting from what appears to be a neofunctionalization of a Hap1-like transcription factor.<\/jats:p>","DOI":"10.3390\/jof8010061","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T03:46:27Z","timestamp":1641527187000},"page":"61","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of the Candida glabrata Transcription Factor CgMar1: Role in Azole Susceptibility"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-416X","authenticated-orcid":false,"given":"Pedro","family":"Pais","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"iBB\u2014Institute of Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"given":"M\u00f3nica","family":"Galocha","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"iBB\u2014Institute of Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-9621","authenticated-orcid":false,"given":"Raquel","family":"Calif\u00f3rnia","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"iBB\u2014Institute of Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"given":"Romeu","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"iBB\u2014Institute of Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"given":"Mihaela","family":"Ola","sequence":"additional","affiliation":[{"name":"School of Biomedical and Biomolecular Sciences, Conway Institute, University College Dublin, Dublin 4, Ireland"}]},{"given":"Michiyo","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center (MMRC), Chiba University, Chiba 263-8522, Japan"}]},{"given":"Hiroji","family":"Chibana","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center (MMRC), Chiba University, Chiba 263-8522, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-5301","authenticated-orcid":false,"given":"Geraldine","family":"Butler","sequence":"additional","affiliation":[{"name":"School of Biomedical and Biomolecular Sciences, Conway Institute, University College Dublin, Dublin 4, Ireland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-6174","authenticated-orcid":false,"given":"Miguel C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"},{"name":"iBB\u2014Institute of Bioengineering and Biosciences, Biological Sciences Research Group, Instituto Superior T\u00e9cnico, 1049-001 Lisboa, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.diagmicrobio.2012.06.012","article-title":"The PATH (Prospective Antifungal Therapy) Alliance\u00ae registry and invasive fungal infections: Update 2012","volume":"73","author":"Azie","year":"2012","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1086\/520192","article-title":"Nosocomial Bloodstream Infections in United States Hospitals: A Three-Year Analysis","volume":"29","author":"Edmond","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12539","article-title":"Global trends in the distribution of Candida species causing candidemia","volume":"20","author":"Guinea","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.cmi.2015.06.010","article-title":"Incidence and species distribution of candidaemia in Asia: A laboratory-based surveillance study","volume":"21","author":"Tan","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijantimicag.2007.03.009","article-title":"Recent advances in antifungal chemotherapy","volume":"30","author":"Petrikkos","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mib.2018.02.005","article-title":"Antifungal drug resistance: Evolution, mechanisms and impact","volume":"45","author":"Revie","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1128\/AAC.49.5.1745-1752.2005","article-title":"Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes","volume":"49","author":"MacPherson","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/EC.3.6.1391-1397.2004","article-title":"Role of Candida albicans Transcription Factor Upc2p in Drug Resistance and Sterol Metabolism","volume":"3","author":"Silver","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2443.2010.01470.x","article-title":"Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata","volume":"16","author":"Nagi","year":"2010","journal-title":"Genes Cells"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1128\/AAC.48.10.3773-3781.2004","article-title":"Azole Resistance in Candida glabrata: Coordinate Upregulation of Multidrug Transporters and Evidence for a Pdr1-Like Transcription Factor","volume":"48","author":"Vermitsky","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1128\/AAC.00811-12","article-title":"Candida glabrata Drug:H+Antiporter CgQdr2 Confers Imidazole Drug Resistance, Being Activated by Transcription Factor CgPdr1","volume":"57","author":"Costa","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1365-2958.2006.05235.x","article-title":"Pdr1 regulates multidrug resistance in Candida glabrata: Gene disruption and genome-wide expression studies","volume":"61","author":"Vermitsky","year":"2006","journal-title":"Mol. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/EC.00073-10","article-title":"Genomewide Expression Profile Analysis of the Candida glabrata Pdr1 Regulon","volume":"10","author":"Caudle","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1128\/AAC.50.4.1384-1392.2006","article-title":"Candida glabrata PDR1, a Transcriptional Regulator of a Pleiotropic Drug Resistance Network, Mediates Azole Resistance in Clinical Isolates and Petite Mutants","volume":"50","author":"Tsai","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/genetics.105.054767","article-title":"A Mutation in Tac1p, a Transcription Factor Regulating CDR1 and CDR2, Is Coupled With Loss of Heterozygosity at Chromosome 5 to Mediate Antifungal Resistance in Candida albicans","volume":"172","author":"Coste","year":"2006","journal-title":"Genetics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/EC.00151-07","article-title":"Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates","volume":"6","author":"Coste","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/EC.3.6.1639-1652.2004","article-title":"TAC1, Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2","volume":"3","author":"Coste","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Morschh\u00e4user, J., Barker, K.S., Liu, T.T., Bla\u00df-Warmuth, J., Homayouni, R., and Rogers, P.D. (2007). The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030164"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2958.2008.06309.x","article-title":"Mutations in the Multi-Drug Resistance Regulator MRR1, Followed by Loss of Heterozygosity, Are the Main Cause of MDR1 Overexpression in Fluconazole-Resistant Candida albicans Strains","volume":"69","author":"Dunkel","year":"2008","journal-title":"Mol. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2004.10.016","article-title":"Drag&Drop Cloning in Yeast","volume":"344","author":"Jansen","year":"2005","journal-title":"Gene"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e00154-18","DOI":"10.1128\/mSphere.00154-18","article-title":"New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi","volume":"3","author":"Vyas","year":"2018","journal-title":"mSphere"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1128\/EC.00414-06","article-title":"Development of a Highly Efficient Gene Targeting System Induced by Transient Repression of YKU80 Expression in Candida glabrata","volume":"6","author":"Ueno","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1080\/21505594.2020.1839231","article-title":"A New Regulator in the Crossroads of Oxidative Stress Resistance and Virulence in Candida glabrata: The Transcription Factor CgTog1","volume":"11","author":"Pais","year":"2020","journal-title":"Virulence"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cavalheiro, M., Rom\u00e3o, D., Santos, R., Mil-Homens, D., Pais, P., Costa, C., Galocha, M., Pereira, D., Takahashi-Nakaguchi, A., and Chibana, H. (2021). Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031376"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ueno, K., Matsumoto, Y., Uno, J., Sasamoto, K., Sekimizu, K., Kinjo, Y., and Chibana, H. (2011). Intestinal Resident Yeast Candida glabrata Requires Cyb2p-Mediated Lactate Assimilation to Adapt in Mouse Intestine. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024759"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e00554-20","DOI":"10.1128\/AAC.00554-20","article-title":"Candida Glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability","volume":"64","author":"Pais","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3389\/fmicb.2016.02045","article-title":"Membrane Proteomics Analysis of the Candida Glabrata Response to 5-Flucytosine: Unveiling the Role and Regulation of the Drug Efflux Transporters CgFlr1 and CgFlr2","volume":"7","author":"Pais","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1074\/mcp.M114.045344","article-title":"Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2","volume":"15","author":"Pais","year":"2016","journal-title":"Mol. Cell. Proteom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1534\/g3.113.006908","article-title":"Expression Plasmids for Use in Candida glabrata","volume":"3","author":"Zordan","year":"2013","journal-title":"G3 Genes|Genomes|Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/AAC.01237-06","article-title":"Role for Cell Density in Antifungal Drug Resistance in Candida albicans Biofilms","volume":"51","author":"Perumal","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jiang, H., Lei, R., Ding, S.-W., and Zhu, S. (2014). Skewer: A Fast and Accurate Adapter Trimmer for next-Generation Sequencing Paired-End Reads. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-182"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: Discovering Splice Junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential Expression Analysis for Sequence Count Data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA-Seq Data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fcimb.2017.00473","article-title":"A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1","volume":"7","author":"Cavalheiro","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1574-6968.1996.tb08000.x","article-title":"Intracellular Acidification Does Not Account for Inhibition of Saccharomyces Cerevisiae Growth in the Presence of Ethanol","volume":"135","author":"Rosa","year":"1996","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D597","DOI":"10.1093\/nar\/gkw817","article-title":"The PathoYeastract Database: An Information System for the Analysis of Gene and Genomic Transcription Regulation in Pathogenic Yeasts","volume":"45","author":"Monteiro","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/bioinformatics\/btr261","article-title":"DREME: Motif Discovery in Transcription Factor ChIP-Seq Data","volume":"27","author":"Bailey","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0076-6879(91)94030-G","article-title":"Preparation of High Molecular Weight RNA","volume":"194","author":"Domdey","year":"1991","journal-title":"Methods Enzymol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/mmi.12983","article-title":"Yap7 Is a Transcriptional Repressor of Nitric Oxide Oxidase in Yeasts, Which Arose from Neofunctionalization after Whole Genome Duplication","volume":"96","author":"Merhej","year":"2015","journal-title":"Mol. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/MCB.00687-10","article-title":"Domains of Tra1 Important for Activator Recruitment and Transcription Coactivator Functions of SAGA and NuA4 Complexes","volume":"31","author":"Knutson","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Proux-W\u00e9ra, E., Armis\u00e9n, D., Byrne, K.P., and Wolfe, K.H. (2012). A Pipeline for Automated Annotation of Yeast Genome Sequences by a Conserved-Synteny Approach. BMC Bioinform., 13.","DOI":"10.1186\/1471-2105-13-237"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/molbev\/mst042","article-title":"Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB","volume":"30","author":"Maguire","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/jac\/dki088","article-title":"Exposure of Candida Albicans to Antifungal Agents Affects Expression of SAP2 and SAP9 Secreted Proteinase Genes","volume":"55","author":"Copping","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"30048","DOI":"10.1074\/jbc.M203385200","article-title":"Identification and Characterization of a Saccharomyces cerevisiae Gene, RSB1, Involved in Sphingoid Long-Chain Base Release","volume":"277","author":"Kihara","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1091\/mbc.e04-06-0458","article-title":"Cross Talk between Sphingolipids and Glycerophospholipids in the Establishment of Plasma Membrane Asymmetry","volume":"15","author":"Kihara","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00018-008-8409-3","article-title":"RTA2 Is Involved in Calcineurin-Mediated Azole Resistance and Sphingoid Long-Chain Base Release in Candida albicans","volume":"66","author":"Jia","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1128\/AAC.00535-10","article-title":"Microarray and Molecular Analyses of the Azole Resistance Mechanism in Candida glabrata Oropharyngeal Isolates","volume":"54","author":"Tsai","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ferrari, S., Sanguinetti, M., Torelli, R., Posteraro, B., and Sanglard, D. (2011). Contribution of CgPDR1-Regulated Genes in Enhanced Virulence of Azole-Resistant Candida glabrata. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017589"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6904","DOI":"10.1128\/AAC.03921-14","article-title":"Identification of Genomic Binding Sites for Candida glabrata Pdr1 Transcription Factor in Wild-Type and \u03a10 Cells","volume":"58","author":"Paul","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1534\/g3.113.010199","article-title":"Phenotypic Analysis of a Family of Transcriptional Regulators, the Zinc Cluster Proteins, in the Human Fungal Pathogen Candida glabrata","volume":"4","author":"Klimova","year":"2014","journal-title":"G3 Genes|Genomes|Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1574-6968.2000.tb09040.x","article-title":"Phospholipid and Sterol Analysis of Plasma Membranes of Azole-Resistant Candida albicans Strains","volume":"185","author":"Einsele","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1038\/s41467-018-06944-1","article-title":"Candida albicans Gains Azole Resistance by Altering Sphingolipid Composition","volume":"9","author":"Gao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.bbamem.2018.05.016","article-title":"Phosphatidylserine Decarboxylase Governs Plasma Membrane Fluidity and Impacts Drug Susceptibilities of Candida albicans Cells","volume":"1860","author":"Khandelwal","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/jac\/dkh336","article-title":"Genome-Wide Expression Profiling Reveals Genes Associated with Amphotericin B and Fluconazole Resistance in Experimentally Induced Antifungal Resistant Isolates of Candida albicans","volume":"54","author":"Barker","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbrc.2008.06.093","article-title":"RTA2, a Novel Gene Involved in Azole Resistance in Candida albicans","volume":"373","author":"Jia","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Wang, L., Jia, Y., Tang, R.-J., Xu, Z., Cao, Y.-B., Jia, X.-M., and Jiang, Y.-Y. (2012). Proteomic Analysis of Rta2p-Dependent Raft-Association of Detergent-Resistant Membranes in Candida albicans. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037768"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e12767","DOI":"10.1111\/cmi.12767","article-title":"Distinct Roles of the 7-Transmembrane Receptor Protein Rta3 in Regulating the Asymmetric Distribution of Phosphatidylcholine across the Plasma Membrane and Biofilm Formation in Candida albicans","volume":"19","author":"Srivastava","year":"2017","journal-title":"Cell. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1128\/AAC.49.6.2226-2236.2005","article-title":"Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans","volume":"49","author":"Liu","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1128\/AAC.00732-16","article-title":"The RTA3 Gene, Encoding a Putative Lipid Translocase, Influences the Susceptibility of Candida albicans to Fluconazole","volume":"60","author":"Whaley","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e00478-16","DOI":"10.1128\/mBio.00478-16","article-title":"Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus Neoformans","volume":"7","author":"Huang","year":"2016","journal-title":"mBio"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Singh, A., Yadav, V., and Prasad, R. (2012). Comparative Lipidomics in Clinical Isolates of Candida Albicans Reveal Crosstalk between Mitochondria, Cell Wall Integrity and Azole Resistance. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039812"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1021\/bi00205a013","article-title":"Interaction of Cholesterol with Sphingomyelin in Monolayers and Vesicles","volume":"33","author":"Bittman","year":"1994","journal-title":"Biochemistry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fgb.2016.05.008","article-title":"Yeast ABC Transporters in Lipid Trafficking","volume":"93","author":"Prasad","year":"2016","journal-title":"Fungal Genet. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bbamem.2013.10.015","article-title":"Effects of Azole Treatments on the Physical Properties of Candida Albicans Plasma Membrane: A Spin Probe EPR Study","volume":"1838","author":"Sgherri","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/1\/61\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:13:01Z","timestamp":1760364781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/1\/61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["jof8010061"],"URL":"https:\/\/doi.org\/10.3390\/jof8010061","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]}}}