{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:39:32Z","timestamp":1764175172470,"version":"build-2065373602"},"reference-count":87,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Internal Grant Agency (IGA) of Mendel University in Brno (IGA number LDF_TP_2019013, name of the project: Histopathological and physiological characteristics of tree species infected with the pathogen of the genus Phytophthora)","award":["LDF_TP_2019013"],"award-info":[{"award-number":["LDF_TP_2019013"]}]},{"name":"Phytophthora Research Centre Reg. No. CZ.02.1.01\/0.0\/0.0\/15_003\/0000453, co-financed by the European Regional Development Fund","award":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000453"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/15_003\/0000453"]}]},{"name":"Slovak scientific grant agency VEGA (1\/0450\/19)","award":["(1\/0450\/19)"],"award-info":[{"award-number":["(1\/0450\/19)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Phytophthora infections are followed by histological alterations, physiological and metabolomic adjustments in the host but very few studies contemplate these changes simultaneously. Fagus sylvatica seedlings were inoculated with A1 and A2 mating types of the heterothallic P. \u00d7cambivora and with the homothallic P. plurivora to identify plant physiological and metabolomic changes accompanying microscope observations of the colonization process one, two and three weeks after inoculation. Phytophthora plurivora-infected plants died at a faster pace than those inoculated with P. \u00d7cambivora and showed higher mortality than P. \u00d7cambivora A1-infected plants. Phytophthora \u00d7cambivora A1 and A2 caused similar progression and total rate of mortality. Most differences in the physiological parameters between inoculated and non-inoculated plants were detected two weeks after inoculation. Alterations in primary and secondary metabolites in roots and leaves were demonstrated for all the inoculated plants two and three weeks after inoculation. The results indicate that P. plurivora is more aggressive to Fagus sylvatica seedlings than both mating types of P. \u00d7cambivora while P. \u00d7cambivora A1 showed a slower infection mode than P. \u00d7cambivora A2 and led to minor plant metabolomic adjustments.<\/jats:p>","DOI":"10.3390\/jof8030298","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T22:09:58Z","timestamp":1647468598000},"page":"298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolomic and Physiological Changes in Fagus sylvatica Seedlings Infected with Phytophthora plurivora and the A1 and A2 Mating Types of P. \u00d7cambivora"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-4728","authenticated-orcid":false,"given":"Tamara","family":"Corcobado","sequence":"first","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-0221","authenticated-orcid":false,"given":"Ivan","family":"Milenkovi\u0107","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"},{"name":"Faculty of Forestry, University of Belgrade, Kneza Vi\u0161eslava 1, 11030 Belgrade, Serbia"}]},{"given":"I\u00f1igo","family":"Saiz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Laboratory of Molecular Biology and Radiobiology, Faculty of AgriSciences, Mendel University in Brno, Zem\u011bd\u011blsk\u00e1 1, 61300 Brno, Czech Republic"}]},{"given":"Tom\u00e1\u0161","family":"Kudl\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"}]},{"given":"Roman","family":"Plichta","sequence":"additional","affiliation":[{"name":"Department of Forest Botany, Dendrology and Geobiocoenology, Faculty of Forestry and Wood Technology, Mendel University in Brno, Zem\u011bd\u011blsk\u00e1 3, 61300 Brno, Czech Republic"}]},{"given":"Tom\u00e1\u0161","family":"M\u00e1jek","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"}]},{"given":"Aneta","family":"Ba\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"}]},{"given":"Henrieta","family":"\u010eatkov\u00e1","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-4832","authenticated-orcid":false,"given":"L\u00e1szl\u00f3 Benedek","family":"D\u00e1lya","sequence":"additional","affiliation":[{"name":"Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Zem\u011bd\u011blsk\u00e1 3, 61300 Brno, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-3415","authenticated-orcid":false,"given":"Milo\u0161","family":"Trifkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Forest Protection and Wildlife Management, Faculty of Forestry and Wood Technology, Mendel University in Brno, Zem\u011bd\u011blsk\u00e1 3, 61300 Brno, Czech Republic"}]},{"given":"Davide","family":"Mureddu","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Sassari, Viale Italia 39, 07100 Sassari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1428-0707","authenticated-orcid":false,"given":"Vladim\u00edr","family":"Ra\u010dko","sequence":"additional","affiliation":[{"name":"Department of Wood Science, Technical University in Zvolen, 96001 Zvolen, Slovakia"}]},{"given":"Monika","family":"Kardo\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Phytology, Technical University in Zvolen, 96001 Zvolen, Slovakia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2351-7638","authenticated-orcid":false,"given":"Jaroslav","family":"\u010eurkovi\u010d","sequence":"additional","affiliation":[{"name":"Department of Phytology, Technical University in Zvolen, 96001 Zvolen, Slovakia"}]},{"given":"Roman","family":"Rattunde","sequence":"additional","affiliation":[{"name":"Institute of Botany, Technische Universit\u00e4t Dresden, 01062 Dresden, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-0718","authenticated-orcid":false,"given":"Thomas","family":"Jung","sequence":"additional","affiliation":[{"name":"Phytophthora Research Centre, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic"},{"name":"Phytophthora Research and Consultancy, Am Rain 9, 83131 Nu\u00dfdorf, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3767\/persoonia.2018.40.08","article-title":"Canker and decline diseases caused by soil- and airborne Phytophthora species in forests and woodlands","volume":"40","author":"Jung","year":"2018","journal-title":"Persoonia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1439-0329.1996.tb00846.x","article-title":"Isolation, identification and pathogenicity of Phytophthora species from declining oak 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