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in recent years. However, sustainable, and economically viable bioprocesses require yeast strains exhibiting: (i) high tolerance to multiple bioprocess-related stresses, including the various chemical inhibitors present in hydrolysates from lignocellulosic biomass and residues; (ii) the ability to efficiently consume all the major carbon sources present; (iii) the capacity to produce lipids with adequate composition in high yields. More than 160 non-conventional (non-Saccharomyces) yeast species are described as oleaginous, but only a smaller group are relatively well characterised, including Lipomyces starkeyi, Yarrowia lipolytica, Rhodotorula toruloides, Rhodotorula glutinis, Cutaneotrichosporonoleaginosus and Cutaneotrichosporon cutaneum. This article provides an overview of lipid production by oleaginous yeasts focusing on yeast diversity, metabolism, and other microbiological issues related to the toxicity and tolerance to multiple challenging stresses limiting bioprocess performance. This is essential knowledge to better understand and guide the rational improvement of yeast performance either by genetic manipulation or by exploring yeast physiology and optimal process conditions. Examples gathered from the literature showing the potential of different oleaginous yeasts\/process conditions to produce oils for biodiesel from agro-forestry and industrial organic residues are provided.<\/jats:p>","DOI":"10.3390\/jof8070687","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues"],"prefix":"10.3390","volume":"8","author":[{"given":"Marta","family":"Mota","sequence":"first","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"},{"name":"i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"}]},{"given":"Paula","family":"M\u00fagica","sequence":"additional","affiliation":[{"name":"BIOREF\u2014Collaborative Laboratory for Biorefineries, Rua da Amieira, Apartado 1089, S\u00e3o Mamede de Infesta, 4465-901 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-5183","authenticated-orcid":false,"given":"Isabel","family":"S\u00e1-Correia","sequence":"additional","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"},{"name":"i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-021-01939-5","article-title":"Waste biorefinery towards a sustainable circular bioeconomy: A solution to global issues","volume":"14","author":"Leong","year":"2021","journal-title":"Biotechnol. Biofuels"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/bbb.2104","article-title":"The role of renewable chemicals and biofuels in building a bioeconomy","volume":"14","author":"Chandel","year":"2020","journal-title":"Biofuels Bioprod. 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