{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:34:05Z","timestamp":1773909245520,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/00709\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["UIDP\/50017\/2020+UIDB\/50017\/2020"],"award-info":[{"award-number":["UIDP\/50017\/2020+UIDB\/50017\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["LA\/P\/0094\/2020"],"award-info":[{"award-number":["LA\/P\/0094\/2020"]}]},{"name":"FCT\/MCTES","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"name":"FCT\/MCTES","award":["UIDP\/00709\/2020"],"award-info":[{"award-number":["UIDP\/00709\/2020"]}]},{"name":"FCT\/MCTES","award":["UIDP\/50017\/2020+UIDB\/50017\/2020"],"award-info":[{"award-number":["UIDP\/50017\/2020+UIDB\/50017\/2020"]}]},{"name":"FCT\/MCTES","award":["LA\/P\/0094\/2020"],"award-info":[{"award-number":["LA\/P\/0094\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Hypertensive disorders in pregnancy (HDP) are the most prevalent diseases during pregnancy. In addition to the already identified risk factors, exposure to environmental contaminants has been also considered a new one. Phthalates, which are classified as priority environmental pollutants due to their ubiquitousness and endocrine disrupting properties, have been implicated in HDP in some epidemiological studies. Nevertheless, phthalates\u2019 vascular impacts still need to be clarified. Thus, we aimed to understand the connection between phthalates exposure and the occurrence of gestational hypertension, as well as the pathway involved in the pathological vascular effects. We investigated diethyl phthalate\u2019s (DEP) effect on the vascular reactivity of the human umbilical arteries (HUAs) from normotensive and hypertensive pregnant women. Both DEP\u2019s nongenomic (within minutes effect) and genomic (24 h exposure to DEP) actions were evaluated, as well as the contribution of cyclic guanosine monophosphate and Ca2+ channel pathways. The results show that short-term exposure to DEP interferes with serotonin and histamine receptors, while after prolonged exposure, DEP seems to share the same vasorelaxant mechanism as estrogens, through the NO\/sGC\/cGMP\/PKG signaling pathway, and to interfere with the L-type Ca2+ channels. Thus, the vascular effect induced by DEP is similar to that observed in HUA from hypertensive pregnancies, demonstrating that the development of HDP may be a consequence of DEP exposure.<\/jats:p>","DOI":"10.3390\/jox14020030","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:30:52Z","timestamp":1713436252000},"page":"497-515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exposure to DEP Modifies the Human Umbilical Artery Vascular Resistance Contributing to Hypertension in Pregnancy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1875-0144","authenticated-orcid":false,"given":"Melissa","family":"Mariana","sequence":"first","affiliation":[{"name":"Health Sciences Research Centre (CICS-UBI), University of Beira Interior, 6200-506 Covilha, Portugal"},{"name":"Faculty of Sciences (FC-UBI), University of Beira Interior, 6201-001 Covilha, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-9470","authenticated-orcid":false,"given":"Amadeu M. V. M.","family":"Soares","sequence":"additional","affiliation":[{"name":"Centre for Environmental and Marine Studies (CESAM-UA), Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-5912","authenticated-orcid":false,"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS-UBI), University of Beira Interior, 6200-506 Covilha, Portugal"},{"name":"Faculty of Health Sciences (FCS-UBI), University of Beira Interior, 6200-506 Covilha, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-5701","authenticated-orcid":false,"given":"Elisa","family":"Cairrao","sequence":"additional","affiliation":[{"name":"Health Sciences Research Centre (CICS-UBI), University of Beira Interior, 6200-506 Covilha, Portugal"},{"name":"Faculty of Health Sciences (FCS-UBI), University of Beira Interior, 6200-506 Covilha, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2021.02.005","article-title":"Hypertension in pregnancy: Prevalence, risk factors and outcomes for women birthing in Ireland","volume":"24","author":"Corrigan","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s40292-023-00582-5","article-title":"Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview","volume":"30","author":"Cifkova","year":"2023","journal-title":"High. 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