{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:55:07Z","timestamp":1767117307141,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["015\/UPR10\/12."],"award-info":[{"award-number":["015\/UPR10\/12."]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Objective: In this pilot clinical study we investigated the effect on blood pressure (BP) of two community-based exercise training programs of high (HIT) vs. low-moderate intensity (LMIT) in hypertensive individuals receiving at least one antihypertensive drug. Methods: The study included two phases of physical exercises based on 1-h session, 3 days\/week for 12 and 16 weeks, respectively, separately by a 7-week resting period. Each phase was preceded by a four-week conditioning training period. According to the average maximal heart rate at baseline, participants were randomized to HIT (80\u201390%), LMIT (50\u201370%) or no-exercise (control). Heart rate was monitored during workout and BP profiles were registered by ambulatory BP monitoring at the beginning and end of each phase. Results: Of 60 individuals randomized, 44 completed the study (HIT, n = 10; LMIT, n = 16; controls, n = 18). BP levels were significantly reduced after the second phase for both LMIT (SBP \u22123.1 mmHg, DBP \u22122.4 mmHg) and HIT (SBP \u221210.8 mmHg, DBP \u22128.3 mmHg). Similar levels of improvement were also found in daytime and night-time BP. Mean attendance of the prescribed training sessions was 87.4 \u00b1 6.2% for HIT and 87.4 \u00b1 5.3% for LMIT during the first phase and 84.1 \u00b1 5.0% and 85.2 \u00b1 5.9% during the second phase, respectively (p = 0.047). Conclusion: Both HIT and LMIT exercise training programs reduced BP but the HIT modality showed a lower rate of compliance with proposed training schedule. Intensity of training should be individually prescribed to improve tolerance to more high intensity exercises.<\/jats:p>","DOI":"10.3390\/jpm11040291","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T03:04:06Z","timestamp":1618196646000},"page":"291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High versus Low-Moderate Intensity Exercise Training Program as an Adjunct to Antihypertensive Medication: A Pilot Clinical Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-0576","authenticated-orcid":false,"given":"Vicente","family":"\u00c1vila-Gand\u00eda","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-1344","authenticated-orcid":false,"given":"Maravillas","family":"S\u00e1nchez-Macarro","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}]},{"given":"Antonio","family":"Luque-Rubia","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-7918","authenticated-orcid":false,"given":"Esther","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n para la Formaci\u00f3n e Invetigaci\u00f3n Sanitarias de la Regi\u00f3n de Murcia, 30003 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-1927","authenticated-orcid":false,"given":"Fernando","family":"C\u00e1novas","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"}]},{"given":"Asensio","family":"L\u00f3pez-Santiago","sequence":"additional","affiliation":[{"name":"Servicio Murciano de Salud, 30120 Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-5502","authenticated-orcid":false,"given":"Francisco Javier","family":"L\u00f3pez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Universidad Cat\u00f3lica de Murcia, 30107 Murcia, Spain"},{"name":"Primary Care Research GroupBiomedical Research Institute of Murcia (IMIB\u2013Arrixaca), 30120 Murcia, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/01.hjh.0000199800.72563.26","article-title":"Lifestyle interventions to reduce raised blood pressure: A systematic review of randomized controlled trials","volume":"24","author":"Dickinson","year":"2006","journal-title":"J. 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