{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:41Z","timestamp":1760145941388,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund (ERDF)","award":["CENTRO-01-0145-FEDER-023369"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-023369"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JVD"],"abstract":"<jats:p>Aging is a complex process inherent to and inevitable in humans. With life expectancy rising, there are concerns about the senior population\u2019s wellbeing, and a hope of preventing certain diseases such as cardiovascular diseases. To achieve it, this study resorts to the implementation of an interventional program based on the comprehensive geriatric assessment model [AGA@4life]. The aim is to evaluate the effect of a new nutritional and exercise regime and evaluate possible changes in nitric oxide (NO) metabolites and endothelin 1 (ET-1). An intervention study was developed with 17 participants with ages of 65 and above. They were evaluated in the beginning [T0] and after eight weeks [T1], where NO metabolites and ET-1 levels were determined by enzymatic assays and the slot blot technique, respectively. There was a significant decrease in ET-1 levels in both the control (p &lt; 0.001) and intervention (p = 0.04) groups from T0 to T1, but there was only a tendency for a decrease in the NO metabolite\u2019s levels in the same conditions [p &gt; 0.05]. Even though the NO metabolite levels did not increase as expected, possibly because of an increase in oxidative stress, the ET-1 levels decreased as expected and the overall results are promising, proving this program could have a beneficial effect on the geriatric population.<\/jats:p>","DOI":"10.3390\/jvd3030026","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:59:54Z","timestamp":1726721994000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Influence of a Personalized Intervention Program\u2014AGA@4life\u2014in the Cardiovascular Diseases: A Biochemical Approach"],"prefix":"10.3390","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4205-980X","authenticated-orcid":false,"given":"Maria","family":"Soares","sequence":"first","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"given":"Catarina","family":"Freitas","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"given":"Maria","family":"Timoteo","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"given":"Ana","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-1554","authenticated-orcid":false,"given":"Ana","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"given":"Jo\u00e3o","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"}]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"},{"name":"H&TRC\u2014Health & Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, Rua 5 de Outubro, 3045-043 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-0506","authenticated-orcid":false,"given":"Armando","family":"Caseiro","sequence":"additional","affiliation":[{"name":"Coimbra Health School, Polytechnic University of Coimbra, Rua da Miseric\u00f3rdia, Lagar dos Corti\u00e7os, S. Martinho do Bispo, 3045-093 Coimbra, Portugal"},{"name":"H&TRC\u2014Health & Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, Rua 5 de Outubro, 3045-043 Coimbra, Portugal"},{"name":"Faculty of Sport Science and Physical Education, University of Coimbra, CIDAF, 3000-456 Coimbra, Portugal"},{"name":"Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3324\/haematol.2015.126771","article-title":"Aging and blood disorders: New perspectives, new challenges","volume":"100","author":"Bron","year":"2015","journal-title":"Haematologica"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Conte, M., Martucci, M., Sandri, M., Franceschi, C., and Salvioli, S. (2019). 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