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lucidum is an extensively famous medicinal mushroom distributed worldwide. Despite being widely grown in Moroccan forests, there are no studies on its nutritional, nutraceutical and pharmaceutical values. Herein, the objective of this study was to investigate the chemical characterization and antimicrobial properties of G. lucidum methanolic extract. Total phenolic, flavonoid, tannin, ascorbic acid and carotenoid contents were determined by spectrophotometry. The results revealed that the most prevalent bioactive compounds were phenolics and flavonoids, with total values of 154.60 mg GAE\/g of dry methanolic extract (dme) and 60.55 mg CE\/mg of dme, respectively. A GC\u2013MS analysis identified 80 biologically active molecules, which were mainly divided into the following major groups: sugars (49.49%), organic acids (8.89%), fatty acids (7.75%), amino acids (7.44%), steroids (7.32%), polyphenols (5.92%), and others (13.16%). Additionally, 22 individual phenolic compounds were identified and quantified using HPLC\u2013MS, with emphasis on kaempferol (1714 \u00b5g\/g of dry weight (dw)), apigenin (1955 \u00b5g\/g dw) and quercetin (947.2 \u00b5g\/g dw). The methanolic extract of G. lucidum indicated strong antioxidant capacity by means of the following: DPPH radical-scavenging activity (53.7 \u00b5g\/mL), \u03b2-carotene\/linoleate assay (43.75 \u00b5g\/mL), and reducing power assay (76.62 \u00b5g\/mL). Furthermore, the extract exhibited potent antimicrobial properties against seven human pathogenic microorganisms, including two bacteria and five fungal strains, at concentrations ranging from 1 to 16 mg\/mL. The most sensitive pathogen was Epidermophyton floccosum (MIC = MFC = 1 mg\/mL), while Aspergillus fumigatus was the most resistant one (MIC = 16 mg\/mL and MFC \u2265 16 mg\/mL). Overall, our findings demonstrated valuable nutritional and bioactive compound attributes, and potent antioxidant and antimicrobial properties, of G. lucidum growing in Moroccan forests. Moreover, these findings suggest that the Moroccan mushroom can be extremely useful for the food and medicinal industries to positively affect socioeconomic status.<\/jats:p>","DOI":"10.3390\/life13051217","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T09:23:10Z","timestamp":1684488190000},"page":"1217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Chemical Characterization and Evaluation of Antimicrobial Properties of the Wild Medicinal Mushroom Ganoderma lucidum Growing in Northern Moroccan Forests"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-9278","authenticated-orcid":false,"given":"El Hadi","family":"Erbiai","sequence":"first","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"},{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Sciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-6530","authenticated-orcid":false,"given":"Benoutman","family":"Amina","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"given":"Abbassi","family":"Kaoutar","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"given":"Rabah","family":"Saidi","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"given":"Zouhaire","family":"Lamrani","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-5809","authenticated-orcid":false,"given":"Eug\u00e9nia","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy, University of Porto (FFUP), 4050-313 Porto, Portugal"},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-3441","authenticated-orcid":false,"given":"Joaquim C. G.","family":"Esteves da Silva","sequence":"additional","affiliation":[{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Sciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9280-3596","authenticated-orcid":false,"given":"Abdelfettah","family":"Maouni","sequence":"additional","affiliation":[{"name":"Biology, Environment, and Sustainable Development Laboratory, ENS, Abdelmalek Essaadi University, Tetouan 93000, Morocco"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-8455","authenticated-orcid":false,"given":"Lu\u00eds","family":"Pinto da Silva","sequence":"additional","affiliation":[{"name":"Chemistry Research Unit (CIQUP), Institute of Molecular Sciences (IMS), Department of Sciences, Environment and Territorial Planning, Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"ref_1","unstructured":"Holmes, K.K., Bertozzi, S., Bloom, B.R., and Jha, P. 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